Checkpoint
inhibitors are able to wake up the immune system fight tumors of new
Fine Chemicals drugs for the treatment of cancer has a significant effect. However, some clinical results indicate that these drugs on the part of the patient and no effect. Recently two research articles on this inner mechanism was explained. The authors argue that this part of the patient's body microbial
populations abnormal, and therefore can not normally generate an immune
response.
This is the first time two studies flora and intestinal immune checkpoint inhibitors linked. Under normal circumstances, a number of immune cell surface receptors to limit its autologous tissue damage. However,
the tumor tissue is also capable of activating these receptors, leading
to specific immune cells can not recognize it and killing. Like ipilimumab and other immune checkpoint inhibitors are able to
block tumor cell activation of these receptors and maintaining the
immune cell activity.
The new study medication can change the way doctors. "These
two articles prove that microbes can affect the treatment effect,"
Institute of Allergy and Infectious Diseases immunologist from the NIH's
Yasmine Belkaid said. Researchers
in the past have often focused on finding the gene mutation in
patients, and thus explain why there are individual differences in
immune checkpoint inhibitor drug treatment. Today's research indicates that in addition to these two genomes of microorganisms may also have the same effect.
2015年11月9日星期一
What is o-aminobenzoate
Chemical properties of o-amino benzoic acid methyl ester, quality standards and uses colorless to pale yellow liquid or white crystal, blue fluorescence, was persistent soft aroma, like orange blossom and certain types of grape aroma. Glycerin and insoluble in water, slightly soluble in propylene glycol, soluble in most of the non-volatile oil, volatile oil, mineral oil, ethanol, and benzyl benzoate. Melting point 17-19 ° C (lit.) Boiling point 256 ° C (lit.) Density 1.126 g / mL at 25 ° C (lit.) Refractive index n20 / D 1.579 (lit.) Flash point> 230 ° F AR quality standards 98% Appearance appearance colorless or slightly yellow liquid infrared Spectroscopy infrared spectrometry comply purity purity & ge; 98.0% (GC) acid value Acid value (mg KOH / g) & le; 1.0 relative density Specific gravity (20/4 ° C) 1.1250-1.1290 refractive index refractive index n20 / D 1.5780-1.5710 use spices. Widely used in the preparation of orange oil, orange blossom, peaches, grapes, grapefruit flavor. Use for organic synthesis. Dangerous nature WGK Germany 1 No. RTECS CB3500000 Hazard Symbols Xi Risk Codes 36/37/38 Safety Instructions 26-36-36 / 37 / 39-22 Storage sealed dry preservation
Studies have shown that CLL patients receiving imatinib treatment according to Lu normal B cells and humoral immunity occurred partially reconstructed
Recently,
an analysis of Sun and his colleagues on the "Blood" published in the
journal, according to Lu imatinib in chronic lymphocytic leukemia (CLL)
patients - after Bruton tyrosine kinase (BTK) inhibitor therapy, normal B cells and humoral immunity occurred partially reconstructed.
BTK plays an essential role in B cell antigen receptor signaling pathway, and is involved in cytokine-mediated signaling pathway in macrophages. In recent years, BTK inhibitors have been used in the treatment of malignant B cell tumors, and mantle cell lymphoma. Relevant literature, according to Lu imatinib - A US Food and Drug Administration (FDA) approved the oral BTK inhibitor, for treatment of refractory / relapsed CLL or untreated CLL, excellent efficacy.
However, it is worth noting that, BTK inhibitors antitumor activity not only depend on the interrupt BCR signaling, adhesion and migration but also targeting Toll-like receptor signaling and B cells. According to Lu CLL patients receiving imatinib after treatment overall response rate was 90%. Since CLL is low agammaglobulinemia and immune disorders characterized by repeated infections cause, so the effect of this combination is very interesting. Given the BTK essential for B cell function is, therefore, according to Lu CLL efficacy of imatinib therapy, need to immunoglobulin levels and the risk of infection is characterized. On the contrary, according to Lu after imatinib treatment, CLL and normal B cell differential sensitivity of BTK inhibitors may promote immune reconstitution.
In order to better define the prognosis of these two aspects, Sun, etc. to give a 86 untreated or refractory / relapsed CLL patients according to Lu imatinib therapy, and for at least 12 months after the patient's humoral and normal B cells to assess the situation. They found that decrease serum IgG levels after 6 months of treatment, as of 24 months was significantly lower (down to 23% of normal). Non-clonal serum IgM levels rapid improvement in six months, while in the 24 months after the time remains the same; the same, clonality serum IgM water 6 months and 24 months on average lower. In addition, during the treatment, 82% of patients with serum IgA levels continue to rise.
It is worth noting that the average decrease of a majority of patients with normal baseline IgG or IgM water, and IgA levels remained unchanged. More importantly, these results with previous findings indicate that most patients receiving imatinib after treatment according to Lu, serum IgG and IgM levels were reduced, while IgA levels are unchanged.
Researchers by analyzing the level of free light chains (FLCs) CLL patients found by the patient according to Lu imatinib therapy showed a normalized κ / λ ratio, rather than clonal FLCs remain stable or slightly elevated, suggesting these are Reconstruction of normal B cells.
Followed by flow cytometry analysis showed that B cells to rebuild normal immunoglobulin levels, the overall level of normal B cells and B cell subsets species, it is very important. Overall, after 12 months of treatment, although normal B cell counts in most patients still unusually low, but 78% of the treatment of young patients and 29% of relapsed / refractory CLL patients had normal B cells, and the presence of the cell cycle. Interestingly, the analysis showed that four patients recovery of normal B cells is still different from the normal population, which shows that at this time the B cell recovery was only partial.
So, these immunological changes impact on infection risk?
Sun and his colleagues found that in the first six-month period of treatment, relapsed / refractory CLL patients with infection rates greater. However, it is evident that the increase in serum IgA levels ≥50% of patients with low infection rates. Meanwhile, pneumonia is one of the long-term adverse effects according to Lu CLL patients after imatinib treatment.
According to Lu imatinib treatment CLL, patients can produce partial reconstruction of humoral and normal B cells and lower infection rates. However, the key problem remains, such as the ability to confirm the clinical results according to Lu erlotinib control CLL higher therapeutic activity, rather than a direct effect of the immune system? In addition, Sun's analysis immunodeficiency CLL not mentioned not only by the humoral immune damage caused, but also caused by normal T cells and natural killer cells dysregulation.
Therefore, a lot of research still needs to fully understand the impact of imatinib according to Lu on the entire immune system. Perhaps, targeting BCR interrupt direct effect does not explain this incomplete immune reconstitution. Therefore, the role of BTK inhibitors on other signaling pathways can affect immune reconstitution, but also need follow-up research to explore. At present, yet according to Lu serum IgA levels after imatinib treatment significantly increased the exact mechanism clear; BTK immune system is not clear and specific role of the so-called normal B cells whether emerging. Conversely, CLL patients after chemotherapy, all serum immunoglobulin were reduced; and after lenalidomide therapy, all serum immunoglobulin increased.
According to Lu imatinib is the first to be approved by the BCR pathway targeting drugs, and is a major breakthrough in the history of CLL treatment. Because according to Lu imatinib is administered continuously, it requires long-term follow-up to accurately assess the role of the drug on the immune system.
BTK plays an essential role in B cell antigen receptor signaling pathway, and is involved in cytokine-mediated signaling pathway in macrophages. In recent years, BTK inhibitors have been used in the treatment of malignant B cell tumors, and mantle cell lymphoma. Relevant literature, according to Lu imatinib - A US Food and Drug Administration (FDA) approved the oral BTK inhibitor, for treatment of refractory / relapsed CLL or untreated CLL, excellent efficacy.
However, it is worth noting that, BTK inhibitors antitumor activity not only depend on the interrupt BCR signaling, adhesion and migration but also targeting Toll-like receptor signaling and B cells. According to Lu CLL patients receiving imatinib after treatment overall response rate was 90%. Since CLL is low agammaglobulinemia and immune disorders characterized by repeated infections cause, so the effect of this combination is very interesting. Given the BTK essential for B cell function is, therefore, according to Lu CLL efficacy of imatinib therapy, need to immunoglobulin levels and the risk of infection is characterized. On the contrary, according to Lu after imatinib treatment, CLL and normal B cell differential sensitivity of BTK inhibitors may promote immune reconstitution.
In order to better define the prognosis of these two aspects, Sun, etc. to give a 86 untreated or refractory / relapsed CLL patients according to Lu imatinib therapy, and for at least 12 months after the patient's humoral and normal B cells to assess the situation. They found that decrease serum IgG levels after 6 months of treatment, as of 24 months was significantly lower (down to 23% of normal). Non-clonal serum IgM levels rapid improvement in six months, while in the 24 months after the time remains the same; the same, clonality serum IgM water 6 months and 24 months on average lower. In addition, during the treatment, 82% of patients with serum IgA levels continue to rise.
It is worth noting that the average decrease of a majority of patients with normal baseline IgG or IgM water, and IgA levels remained unchanged. More importantly, these results with previous findings indicate that most patients receiving imatinib after treatment according to Lu, serum IgG and IgM levels were reduced, while IgA levels are unchanged.
Researchers by analyzing the level of free light chains (FLCs) CLL patients found by the patient according to Lu imatinib therapy showed a normalized κ / λ ratio, rather than clonal FLCs remain stable or slightly elevated, suggesting these are Reconstruction of normal B cells.
Followed by flow cytometry analysis showed that B cells to rebuild normal immunoglobulin levels, the overall level of normal B cells and B cell subsets species, it is very important. Overall, after 12 months of treatment, although normal B cell counts in most patients still unusually low, but 78% of the treatment of young patients and 29% of relapsed / refractory CLL patients had normal B cells, and the presence of the cell cycle. Interestingly, the analysis showed that four patients recovery of normal B cells is still different from the normal population, which shows that at this time the B cell recovery was only partial.
So, these immunological changes impact on infection risk?
Sun and his colleagues found that in the first six-month period of treatment, relapsed / refractory CLL patients with infection rates greater. However, it is evident that the increase in serum IgA levels ≥50% of patients with low infection rates. Meanwhile, pneumonia is one of the long-term adverse effects according to Lu CLL patients after imatinib treatment.
According to Lu imatinib treatment CLL, patients can produce partial reconstruction of humoral and normal B cells and lower infection rates. However, the key problem remains, such as the ability to confirm the clinical results according to Lu erlotinib control CLL higher therapeutic activity, rather than a direct effect of the immune system? In addition, Sun's analysis immunodeficiency CLL not mentioned not only by the humoral immune damage caused, but also caused by normal T cells and natural killer cells dysregulation.
Therefore, a lot of research still needs to fully understand the impact of imatinib according to Lu on the entire immune system. Perhaps, targeting BCR interrupt direct effect does not explain this incomplete immune reconstitution. Therefore, the role of BTK inhibitors on other signaling pathways can affect immune reconstitution, but also need follow-up research to explore. At present, yet according to Lu serum IgA levels after imatinib treatment significantly increased the exact mechanism clear; BTK immune system is not clear and specific role of the so-called normal B cells whether emerging. Conversely, CLL patients after chemotherapy, all serum immunoglobulin were reduced; and after lenalidomide therapy, all serum immunoglobulin increased.
According to Lu imatinib is the first to be approved by the BCR pathway targeting drugs, and is a major breakthrough in the history of CLL treatment. Because according to Lu imatinib is administered continuously, it requires long-term follow-up to accurately assess the role of the drug on the immune system.
Medical breakthrough anti-cancer immunotherapy PD-1 drugs (pembrolizumab) lasting effect
Immunotherapy
by stimulating the immune system to attack tumor cells, and its
mechanism than traditional chemotherapy and target have a more lasting
cure response, low side effects. Wherein
the anti-PD-1 drugs (pembrolizumab) is a US FDA approved the first
immunotherapy for metastatic squamous and non-squamous non-small cell
lung cancer drug is approved, its effectiveness empirical research data -
almost 90% of PD-L1 high expression in lung cancer patients with tumor shrinkage of the
situation, while nearly 60% in patients with low expression of PD-L1
also equally positive response [1], with advanced lung cancer treatment
breakthroughs.
Hong Kong medical oncology specialist Dr. Lu Kaizu to lung cancer as the example illustrates the anti-PD-1 Immunotherapy drugs (pembrolizumab) lasting efficacy, fewer side effects.
Lung Cancer Mortality among the first in China, a total of 652,842 cases of the disease [2], of which 85% are non-small cell lung cancer [3]. Hong Kong medical oncology specialist Dr. Lu Kaizu said: "in the past to accept Taxotere chemotherapy in lung cancer patients, the median overall survival (OS) was only 5.7 months, more side effects, affecting the quality of life of patients in April 2015 published online." Results KEYNOTE-001 New England Journal of Medicine "on the display of anti-PD-1 immunotherapy drugs (pembrolizumab), the median overall survival was 12 months, the results are satisfactory. anti-PD-1 drugs (pembrolizumab) of high security, Adverse events rate to 1-2%, while several studies also show anti-PD-1 immunotherapy produce positive effects in the treatment of various cancer treatment. "
The key point is that blocking tumor cell immunotherapy PD-1 / PD-L1 signaling pathway. There are PD-1 receptor T cells (a kind of white blood cells) of the immune system, once the receptor in combination with other protein PD-L1 cells, T cells will stop making attacks. Stop cancer cell itself to attack cancer cells through different mechanisms of suppression of the immune system, when cancer cells exhibited PD-L1 protein, combined with the PD-1 receptor on T cells, T cells can not recognize the tumor cells Cancer cells in the human body will breed. Anti-PD-1 drugs principle is to stimulate white blood cell cancer awareness, blocks tumor cell PD-1 / PD-L1 signal pathway, through their immune system to attack cancer cells.
Anti-PD-1 drugs (pembrolizumab) has been the US FDA [4], the European Union EU [5] and the British Institute for Healthcare Optimization (NICE) [6] Certification treatment of advanced melanoma, research data indicate that the anti-PD-1 compared with the anti-drugs CTLA-4 drugs effectively improve the survival rate of 30%. At present, anti-PD-1 drugs (pembrolizumab) 100 clinical test 30 different tumors, shown to have the potential to treat many types of cancer.
Compared to other cancer treatments, the immune system "memory", effective sustainable advantage. Target treatment only to have specific targets to issue attacks, if the patient's body without the corresponding target cancer cells, the drug will not produce effective, targeted therapies occur simultaneously resistant, no immune response to treatment lasting advantage.
Hong Kong medical oncology specialist Dr. Lu Kaizu to lung cancer as the example illustrates the anti-PD-1 Immunotherapy drugs (pembrolizumab) lasting efficacy, fewer side effects.
Lung Cancer Mortality among the first in China, a total of 652,842 cases of the disease [2], of which 85% are non-small cell lung cancer [3]. Hong Kong medical oncology specialist Dr. Lu Kaizu said: "in the past to accept Taxotere chemotherapy in lung cancer patients, the median overall survival (OS) was only 5.7 months, more side effects, affecting the quality of life of patients in April 2015 published online." Results KEYNOTE-001 New England Journal of Medicine "on the display of anti-PD-1 immunotherapy drugs (pembrolizumab), the median overall survival was 12 months, the results are satisfactory. anti-PD-1 drugs (pembrolizumab) of high security, Adverse events rate to 1-2%, while several studies also show anti-PD-1 immunotherapy produce positive effects in the treatment of various cancer treatment. "
The key point is that blocking tumor cell immunotherapy PD-1 / PD-L1 signaling pathway. There are PD-1 receptor T cells (a kind of white blood cells) of the immune system, once the receptor in combination with other protein PD-L1 cells, T cells will stop making attacks. Stop cancer cell itself to attack cancer cells through different mechanisms of suppression of the immune system, when cancer cells exhibited PD-L1 protein, combined with the PD-1 receptor on T cells, T cells can not recognize the tumor cells Cancer cells in the human body will breed. Anti-PD-1 drugs principle is to stimulate white blood cell cancer awareness, blocks tumor cell PD-1 / PD-L1 signal pathway, through their immune system to attack cancer cells.
Anti-PD-1 drugs (pembrolizumab) has been the US FDA [4], the European Union EU [5] and the British Institute for Healthcare Optimization (NICE) [6] Certification treatment of advanced melanoma, research data indicate that the anti-PD-1 compared with the anti-drugs CTLA-4 drugs effectively improve the survival rate of 30%. At present, anti-PD-1 drugs (pembrolizumab) 100 clinical test 30 different tumors, shown to have the potential to treat many types of cancer.
Compared to other cancer treatments, the immune system "memory", effective sustainable advantage. Target treatment only to have specific targets to issue attacks, if the patient's body without the corresponding target cancer cells, the drug will not produce effective, targeted therapies occur simultaneously resistant, no immune response to treatment lasting advantage.
pejvak molecules in the body's hearing system plays an important role
Recently,
scientists from the Pasteur Institute, etc. The study found a molecular
feature called pejvakin of, pejvakin molecules in the body's hearing
system plays an important role, the molecule is missing is the main
cause of noise-induced hearing loss, and noise-induced hearing loss is a common cause of deafness, the study published in the International Journal of Cell.
Back in 2006, the researcher identified through a joint research initiated early sensorineural hearing loss novel gene and protein encoded by this gene, called pejvakin, by measuring the hearing test results show that the gene mutation individuals On hearing impairment showed abnormally high levels of diversity; in this latest study, the researchers aim is to cause of disease heterogeneity classification.
Article, researchers pejvakin gene inactivation young mice, the researchers found that among different mouse mutants will lead to hearing damage mice hearing loss from mild to severe, born during the first three mice week given a higher noise, especially during feeding; As the number of mice in cages, which are more and more noisy acoustic environment, researchers observed, as the number of mice in the cage increases, Listening boundaries mice also increases, the minimum level of sound that is heard more and more obvious; the use of the direct control of acoustic stimuli, the scientists discovered that the auditory system pejvakin gene deficient mice is affected by the acoustic environment.
Then the scientists investigated the cause of this phenomenon physiology, researchers in mice missing pejvakin the body observed in mice exposed to a seemingly harmless once sound environment, they will damage the auditory sensory cells; auditory senses cells need two weeks to restore functionality silence again, with longer or repeated exposure to this environment, mouse auditory sensory cells of the body will die; at the same time the scientists also found that the cells in noise-sensitive element is a peroxisome, that can participate in detoxification organelles, simply, a genetic disorder caused by noise-induced hearing loss can be a very low noise level targeting.
the body of the patient pejvakin auditory sensory cell damage often susceptible to noise, and when the individual hearing defect standardized listening tests, the reaction of their auditory sensory cells or neurons Though initially appeared normal, but as tests on It becomes worsening, even loss of function occurs. Noise induced hearing loss occurs more frequently in the population, the urban population centralization means cities will become increasingly noisy, especially in developed countries, according to WHO speculated that by 2030 there will be 1 billion people will risk in noise-induced hearing loss among.
Scientists hope to use existing tools to help restore pejvakin gene function, especially the use of gene therapy to restore its function, and gene therapy has been shown to successfully restore hearing pejvakin deficient mice, even in excessive mouse exposure to noise can still be successfully restored hearing in mice.
Back in 2006, the researcher identified through a joint research initiated early sensorineural hearing loss novel gene and protein encoded by this gene, called pejvakin, by measuring the hearing test results show that the gene mutation individuals On hearing impairment showed abnormally high levels of diversity; in this latest study, the researchers aim is to cause of disease heterogeneity classification.
Article, researchers pejvakin gene inactivation young mice, the researchers found that among different mouse mutants will lead to hearing damage mice hearing loss from mild to severe, born during the first three mice week given a higher noise, especially during feeding; As the number of mice in cages, which are more and more noisy acoustic environment, researchers observed, as the number of mice in the cage increases, Listening boundaries mice also increases, the minimum level of sound that is heard more and more obvious; the use of the direct control of acoustic stimuli, the scientists discovered that the auditory system pejvakin gene deficient mice is affected by the acoustic environment.
Then the scientists investigated the cause of this phenomenon physiology, researchers in mice missing pejvakin the body observed in mice exposed to a seemingly harmless once sound environment, they will damage the auditory sensory cells; auditory senses cells need two weeks to restore functionality silence again, with longer or repeated exposure to this environment, mouse auditory sensory cells of the body will die; at the same time the scientists also found that the cells in noise-sensitive element is a peroxisome, that can participate in detoxification organelles, simply, a genetic disorder caused by noise-induced hearing loss can be a very low noise level targeting.
the body of the patient pejvakin auditory sensory cell damage often susceptible to noise, and when the individual hearing defect standardized listening tests, the reaction of their auditory sensory cells or neurons Though initially appeared normal, but as tests on It becomes worsening, even loss of function occurs. Noise induced hearing loss occurs more frequently in the population, the urban population centralization means cities will become increasingly noisy, especially in developed countries, according to WHO speculated that by 2030 there will be 1 billion people will risk in noise-induced hearing loss among.
Scientists hope to use existing tools to help restore pejvakin gene function, especially the use of gene therapy to restore its function, and gene therapy has been shown to successfully restore hearing pejvakin deficient mice, even in excessive mouse exposure to noise can still be successfully restored hearing in mice.
2015年11月8日星期日
Yangxueqingnaokeli - the gospel of patients with migraine
Migraine is a recurrent throbbing headache, is a headache of many types of "big." It is a kind of gradual deterioration of disease, the incidence frequency is usually higher. Migraine
throbbing pain on one side of the head appeared about a few minutes to
one hour, and gradually increased until the nausea, vomiting, feeling
will be improved in a quiet, dark environment or within headache relief
after sleep. It may be associated with neurological, psychiatric dysfunction or prior to the onset of headache. Research shows that migraine patients are more prone to cerebral damage than usual, and thus lead to a stroke. The frequency of its migraine more areas of the brain injured will be. Long
pain into stasis, "no pain", plus head for Zhu Yang will, Jue Yin
hepatic vein and will be at the summit, described the pathology of
migraine mainly related to the liver qi and stasis. Treatment focuses on liver qi, promoting blood circulation. Migraine crowd to pay attention to the following aspects:
1, less touch 3C foodCheese cheese (Cheese), chocolate (Chocolate), citrus foods (Citrous fruit), as well as pickled sardines, chicken liver, tomatoes, milk, lactic acid drinks, rich in tyrosine. The tyrosine is the main contributing factors to vasospasm, so if you have a history of migraine headaches, it is best to stay away from these foods.
2, careful use of painkillers, cold syrupPainkillers may be a tempting trap. Many people in private painkillers in an attempt to relieve the pain, but excessive use of painkillers, the pain can not be resolved only contrary will cause drug-induced "rebound headaches" so that you suffer from chronic migraine headaches. If you eat more than two a week, or three times a painkiller to relieve pain, see a doctor immediately!
3, migraine patients should avoid cold and chillsEasy to damage the human body yang chill, causing meridians closed resistance, while trigger migraine headaches. Such as washing the hair does not dry on the bed or go out. After 10 minutes, the cold or cold stimulation can cause headaches. Forget the middle of winter to go out wearing a hat, the head is exposed to cold air; swimming water temperature is too low; after eating ice cream or cold drinks can cause irritation headache. The mechanism may be caused by vasomotor disorders and autonomic nervous system dysfunction.
4, massage points conditioning - missing out hole"Yellow Emperor" is recorded, missing points mainly treat migraine, headache, stiff neck and other diseases. "Acupuncture Dacheng" kuai moxibustion has a population of four general points song, which one is: "first item to find out missing" That neck-up of disease can be used to treat and regulate these points. Indications stiff neck, migraine, mouth crooked eye oblique, there are secondary effects of colds, asthma, cough, toothache. The crowd: the head, neck pain often people. Cause of being cold and cause headaches, lack of points can be sparse columns by rubbing the guard of the table. Many white-collar workers now have experienced migraine.
5, massage points taking YANGXUEQINGNAOKELI no matter whenTasly Pharmaceutical Group Co., Ltd. production YANGXUEQINGNAOKELI name from the TCM party "four things soup", the main component of angelica root, foxglove, mother of pearl, cassia, Prunella and peony, of which Rehmannia blood, Angelica blood, blood, nourishing yin convergence peony, Chuanxiong Huoxuezhitong. So, YANGXUEQINGNAOKELI with nourishing blood, calming liver yang, Huoxuetongluo effect. Most drug owned by the liver, as cited by migraine drug.
1, less touch 3C foodCheese cheese (Cheese), chocolate (Chocolate), citrus foods (Citrous fruit), as well as pickled sardines, chicken liver, tomatoes, milk, lactic acid drinks, rich in tyrosine. The tyrosine is the main contributing factors to vasospasm, so if you have a history of migraine headaches, it is best to stay away from these foods.
2, careful use of painkillers, cold syrupPainkillers may be a tempting trap. Many people in private painkillers in an attempt to relieve the pain, but excessive use of painkillers, the pain can not be resolved only contrary will cause drug-induced "rebound headaches" so that you suffer from chronic migraine headaches. If you eat more than two a week, or three times a painkiller to relieve pain, see a doctor immediately!
3, migraine patients should avoid cold and chillsEasy to damage the human body yang chill, causing meridians closed resistance, while trigger migraine headaches. Such as washing the hair does not dry on the bed or go out. After 10 minutes, the cold or cold stimulation can cause headaches. Forget the middle of winter to go out wearing a hat, the head is exposed to cold air; swimming water temperature is too low; after eating ice cream or cold drinks can cause irritation headache. The mechanism may be caused by vasomotor disorders and autonomic nervous system dysfunction.
4, massage points conditioning - missing out hole"Yellow Emperor" is recorded, missing points mainly treat migraine, headache, stiff neck and other diseases. "Acupuncture Dacheng" kuai moxibustion has a population of four general points song, which one is: "first item to find out missing" That neck-up of disease can be used to treat and regulate these points. Indications stiff neck, migraine, mouth crooked eye oblique, there are secondary effects of colds, asthma, cough, toothache. The crowd: the head, neck pain often people. Cause of being cold and cause headaches, lack of points can be sparse columns by rubbing the guard of the table. Many white-collar workers now have experienced migraine.
5, massage points taking YANGXUEQINGNAOKELI no matter whenTasly Pharmaceutical Group Co., Ltd. production YANGXUEQINGNAOKELI name from the TCM party "four things soup", the main component of angelica root, foxglove, mother of pearl, cassia, Prunella and peony, of which Rehmannia blood, Angelica blood, blood, nourishing yin convergence peony, Chuanxiong Huoxuezhitong. So, YANGXUEQINGNAOKELI with nourishing blood, calming liver yang, Huoxuetongluo effect. Most drug owned by the liver, as cited by migraine drug.
Autumn and winter, white-collar workers but also to guard against cardiovascular disease
So
many young white-collar workers is the envy of a group, however,
"karoshi", "sub" and other diseases, but more and more have happened to
them, their big success trend synonymous. National
Health Survey: China's urban white-collar workers up to 76% the
proportion of sub-health, 10 years in male patients with acute coronary
artery disease 45-49 age group increased by 50%. Experts said that for young people the dangers of cardiovascular disease is much greater than the elderly. Studies have shown that mortality in patients 25-34 years of age up to 74.9%. And youth competition, the spirit of high tension often occurs more cardiovascular disease adds a lot of danger.With autumn and winter is the high incidence of cardiovascular and cerebrovascular diseases. This
is because the cold and warm autumn and winter climate uncertain,
larger temperature changes, cold stimulation, cause sudden contraction
of blood vessels, leading to stenosis, blood flow is blocked, the brain
caused by insufficient blood supply to the heart, causing heart and
cerebrovascular diseases. Experts advise, autumn and winter, the white-collar crowd the prevention of cardiovascular disease from the following aspects:1, take part in physical activity, maintaining a reasonable weight. Lack
of physical activity, obesity, work pressure is particularly large,
poor eating habits are the main reasons leading to cardiovascular
disease ahead of the invasion of young white-collar workers, especially
obesity, smoking will replace become the number one cause of heart
disease and stroke. Modern in cars become a fashion, in fact, usually more than walk the
streets to prevent heart disease, the easiest and most convenient
recipe.2, quit smoking, limit alcohol. Nicotine
in tobacco can promote the release of angiotensin, blood vessel spasm
contraction induced cardiovascular and cerebrovascular diseases. Alcohol can damage endothelial cells and accelerate lipid deposition
in the vessel wall, resulting in the occurrence of atherosclerosis
induced cardiovascular and cerebrovascular diseases.3, balanced diet. High-sugar, high-fat diet will accelerate, increase the cardiovascular and cerebrovascular diseases. Always pay attention to meat and vegetables, a balanced diet, eat vitamin-rich vegetables, fruits and other foods.4, maintaining optimism, avoiding stress is a good way to prevent cardiovascular disease. Learn to relax the pressure to work better. Good
mood will make breathing steady, unobstructed blood, contrary
nervousness vascular spasm induced cardiovascular and cerebrovascular
diseases. In
the work stress, prone to cerebral insufficiency due to the emergence
of headaches, insomnia, dreams pressure, the time may wish to take the
Tasly Pharmaceutical Group Co., Ltd. production Yangxueqingnao
(particles / pill). It
is made on the basis of addition and subtraction Siwutang on the
expansion of cerebral blood vessels, increase cerebral blood flow,
improve brain microcirculation, increase brain blood oxygen, reducing
vascular resistance, ease spasm, reduce blood viscosity, inhibiting
platelet aggregation ,
antithrombotic, while acting on the central nervous system, there is a
good sedative and analgesic effects, not only to timely treatment,
relieve headaches, insomnia, can also be effective in preventing "senile
dementia" and "cerebral" occurs, is currently Treatment of chronic cerebral insufficiency preferred medicine.
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