Japan, "Asahi Shimbun" reported that recently, the research team of Japan National Cancer Research Center announced that it has developed a new research method for detecting cancer. Using this method, you only need a small amount of blood samples, it is possible to comprehensively on 60 kinds of genetic material associated with cancer comprehensive testing.
Prior to this, if you want to perform the same comprehensive testing, cancer patients often need to extract parts of the organization to carry out testing. The new detection method can avoid increasing the burden on the premise of the patient's body, repeated constantly on the degree of progress of cancer patients were detected, according to test results and thus able to select the corresponding drug.
Due to the latest research results have demonstrated that although associated with the different types of breast cancer, lung cancer and other genetic material unusual circumstances are not the same, but there are some exceptions genetic material is all kinds of cancer are common. Thus, in a particular abnormal genetic material anticancer drugs that target, if for a particular type of cancer produce a therapeutic effect, it is possible also to other types of cancer have a role. However, to fully enlist cancer-related genetic material abnormality comprehensive testing, it must be extracted cancerous tissue puncture site by other methods.
To this end, the research team of Japan National Cancer Research Center focuses on penetration from the cancerous tissue into the patient's blood is extremely small amounts of DNA, using the most advanced analytical equipment, blood for 48 pancreatic cancer patients from the cancerous tissue penetration carried out DNA detection. Through continuous improvement of the analytical method for the detection of data, the research team in each patient 5 ml blood, are correctly detected 60 kinds of abnormal genetic material. In this regard, research project leader, he said, since it has been confirmed that the new detection method is suitable for pancreatic cancer, then it should also be applied to all types of cancer.
2016年1月6日星期三
Methyl - cyclodextrin price
Product name: Methyl - cyclodextrin
CAS no.: 128446-36-6
Molecular Formula: （C6H10O5）7(CH2)n n=1~21
Molecular Weight: 1303.3
Appearance: White Powder
Purity: ≥98%
Product description: In Medical field, it can promotes the dissolusion efficiency of the drugs, enhancing bioavailability and solubility of drugs,so that to reduce the dose but increase the efficacy, mainly used in medicine of oral liquid.
Would like to ask specific details, please click here Email:sales@chemicalspharm.com
What is Pure scopolamine
Molecular Formula:C17H21NO4
Molecular Weight:303.353g/mol
Description:Scopolamine, also known as levo-duboisine, and hyoscine, is a tropane alkaloid drug with muscarinic antagonist effects.The drug is used in eye drops to induce mydriasis (pupillary dilation) and cycloplegia (paralysis of the eye focusing muscle), primarily in the treatment of eye disorders that benefit from its prolonged effect, e.g. uveitis, iritis, iridocyclitis, etc.
Would like to ask specific details, please click here Email:sales@chemicalspharm.com
Smokers welfare? UK MHRA approved electronic cigarette medicine
Electronic cigarette is a kind of imitation cigarettes electronic products, by atomizing the nicotine into a vapor allows users to smoke, mainly by the smoke pipe, atomizer and battery of three parts, allowing users to generate the feeling of smoking cigarettes. Attitude towards the world of electronic cigarettes vary, some opposition, some believe that it can serve as a substitute for cigarettes and help smokers quit, there's no clear statement. However, recently the UK Drug Administration agency (MHRA) is an electronic cigarette issued permit, which was identified as drugs, may appear in future NHS prescriptions issued in the approval.
The MHRA approval is obtained BAT Group's electronic cigarette e-Voke, future doctors may be prescribing as a smoking cessation aid.
In the long run, e-Voke before quitting aids as possible to help the NHS would save a lot of money, but in the UK's National Institute for Health and Clinical Excellence (NICE) finds its value for money and posting guidelines, is not yet able to into the health insurance.
Although the electronic cigarette gained recognition MHRA and some experts, however, the long-term safety regulation remains an issue, WHO recommendations should prevent users from using electronic cigarettes indoors.
Just a few weeks ago, the University of California researchers published a paper, electronic cigarettes may not be safer than cigarettes in the Oral Oncology. As electronic cigarettes are smoked by atomizing nicotine allows users, although avoiding other harmful substances in tobacco produced in the combustion process, but nicotine itself is still possible to damage DNA and cause cancer. Tim Ballard of the Royal College of General Practitioners also said that before there is sufficient evidence to prove the safety of electronic cigarettes and help smokers quit effectiveness, they will not let the electronic cigarette appears in the prescription.
In terms of security of electronic cigarettes last year, the British public health system has released an independent review of the report, which represents the electronic cigarette safety than traditional cigarettes 95 percent. However, the spokesman for the British Ministry of Health or stressed, for their own health, smokers better quit completely.
Tobacco leads to 100,000 deaths each year, more than eighty percent of lung cancer and oral cancer and throat cancer and other 13 kinds of cancers are caused by smoking. Quitting tobacco control is an important means to improve national health, smoking away from the source of this bad behavior, is the most effective tobacco control measures
The MHRA approval is obtained BAT Group's electronic cigarette e-Voke, future doctors may be prescribing as a smoking cessation aid.
In the long run, e-Voke before quitting aids as possible to help the NHS would save a lot of money, but in the UK's National Institute for Health and Clinical Excellence (NICE) finds its value for money and posting guidelines, is not yet able to into the health insurance.
Although the electronic cigarette gained recognition MHRA and some experts, however, the long-term safety regulation remains an issue, WHO recommendations should prevent users from using electronic cigarettes indoors.
Just a few weeks ago, the University of California researchers published a paper, electronic cigarettes may not be safer than cigarettes in the Oral Oncology. As electronic cigarettes are smoked by atomizing nicotine allows users, although avoiding other harmful substances in tobacco produced in the combustion process, but nicotine itself is still possible to damage DNA and cause cancer. Tim Ballard of the Royal College of General Practitioners also said that before there is sufficient evidence to prove the safety of electronic cigarettes and help smokers quit effectiveness, they will not let the electronic cigarette appears in the prescription.
In terms of security of electronic cigarettes last year, the British public health system has released an independent review of the report, which represents the electronic cigarette safety than traditional cigarettes 95 percent. However, the spokesman for the British Ministry of Health or stressed, for their own health, smokers better quit completely.
Tobacco leads to 100,000 deaths each year, more than eighty percent of lung cancer and oral cancer and throat cancer and other 13 kinds of cancers are caused by smoking. Quitting tobacco control is an important means to improve national health, smoking away from the source of this bad behavior, is the most effective tobacco control measures
Low life contribute to weight loss? - Gut microbes in trouble
If only to reduce the body's thermostat a few weeks the state will be able to play a slimming effect, sound is not that great? Researchers have recently discovered that this is indeed a viable option, at least in mice can produce short-term results. The reason, perhaps the bacteria in their intestinal trouble.
Gastroenterology experts from the University of Minnesota's Alexander Khoruts said the study found a new microbial community on physiological characteristics of the host. Such research may eventually help us find the key substance secreted by microorganisms to help control people's weight.
Gut microbes refers intestinal parasites in the host bacteria and other life forms. A series of studies have shown that gut microbes involved in a number of physiological activities of the body, affecting a large range. In order to further understanding, from the University of Geneva in Switzerland physiologist Mirko Trajkovski, who for the relationship between the gut microbiota and metabolism study conducted in-depth. Previous studies have told them some gut microbes once missing, the body temperature of the environment will no longer be able to maintain body temperature. He therefore considered the gut microbes and the body temperature control, and there may be some link between body weight.
In order to clarify this issue, they analyzed the types of experimental mice intestinal parasitic microorganisms. These mice optimum temperature is 21 degrees life, the temperature was lowered to 6-11 degrees, for a period of one month (to be placed in the wild mice similar living environment). During the experiment the researchers continuously measures body temperature of mice, sampling their droppings, and wickedness of some other metabolic indicators, such as insulin intake and fat accumulation of species.
Under normal circumstances, the body weight of mice with age becomes larger increase in body temperature constant. Test, low temperature processing can instantly reduce the body temperature, so the mice had to burn fat for energy. While blood glucose levels will be reduced, increasing the sensitivity of mice to insulin. In addition, they are also types of intestinal microbial change significantly. A class called Akkermansia muciniphila bacteria (often associated with obesity and diabetes are closely related) disappear. Once this happens, the mouse will no longer be able to skillfully digest food to produce energy. The author's research results published in the "cell" the latest issue of the magazine.
However, a week after treatment, weight loss trend began to stop, intestinal ability to absorb energy and begin to recover. Anatomy of the test results showed that the mice increased intestinal surface area, thus the efficiency of digestion of food increased.
In order to examine whether changes in microbial species produce these physiological changes. Researchers microbes living cryogenic mice removed and transferred to a sterile normal mice treated intestine. The results show that these mice with previous similar weight loss phenomenon.
Gastroenterology experts from the University of Minnesota's Alexander Khoruts said the study found a new microbial community on physiological characteristics of the host. Such research may eventually help us find the key substance secreted by microorganisms to help control people's weight.
Gut microbes refers intestinal parasites in the host bacteria and other life forms. A series of studies have shown that gut microbes involved in a number of physiological activities of the body, affecting a large range. In order to further understanding, from the University of Geneva in Switzerland physiologist Mirko Trajkovski, who for the relationship between the gut microbiota and metabolism study conducted in-depth. Previous studies have told them some gut microbes once missing, the body temperature of the environment will no longer be able to maintain body temperature. He therefore considered the gut microbes and the body temperature control, and there may be some link between body weight.
In order to clarify this issue, they analyzed the types of experimental mice intestinal parasitic microorganisms. These mice optimum temperature is 21 degrees life, the temperature was lowered to 6-11 degrees, for a period of one month (to be placed in the wild mice similar living environment). During the experiment the researchers continuously measures body temperature of mice, sampling their droppings, and wickedness of some other metabolic indicators, such as insulin intake and fat accumulation of species.
Under normal circumstances, the body weight of mice with age becomes larger increase in body temperature constant. Test, low temperature processing can instantly reduce the body temperature, so the mice had to burn fat for energy. While blood glucose levels will be reduced, increasing the sensitivity of mice to insulin. In addition, they are also types of intestinal microbial change significantly. A class called Akkermansia muciniphila bacteria (often associated with obesity and diabetes are closely related) disappear. Once this happens, the mouse will no longer be able to skillfully digest food to produce energy. The author's research results published in the "cell" the latest issue of the magazine.
However, a week after treatment, weight loss trend began to stop, intestinal ability to absorb energy and begin to recover. Anatomy of the test results showed that the mice increased intestinal surface area, thus the efficiency of digestion of food increased.
In order to examine whether changes in microbial species produce these physiological changes. Researchers microbes living cryogenic mice removed and transferred to a sterile normal mice treated intestine. The results show that these mice with previous similar weight loss phenomenon.
Metoprolol Tartrate
Product name: Metoprolol Tartrate
CAS no.: 56392-17-7
Molecular Formula: 2C15H25NO3.C4H6O6
Molecular Weight: 684.82
Product description: Used to treat high blood pressure and angina pectoris.
2016年1月5日星期二
2015 Biomedical Development Review
United States
Brain research has made new achievements, medicine and disease prevention has made a number of major breakthroughs in synthetic biology achievement scene.
Subject Field (newspaper reporter stationed in the United States) in 2015, American scientists made a major breakthrough in the field of brain research: in August, Ohio State University to breed almost fully formed human brain in the laboratory, although it has only a pencil eraser then large, the degree of development and a 5-week-old fetal brain quite, yet there is no awareness, but with the vast majority of cell types and brain function, and can be like the human brain gene expression, using it can help scientists to test new drugs and more more understanding of the disease mechanisms of the brain; in September, the University of Washington research team completed the most complex human brain directly connected experiments, they used a brain - brain directly connected, so five pairs of subjects brain signals transmitted via the Internet to play Answers game. This trial was the first proof of two brain can be connected directly, and without sound, one can accurately guess the other ideas. In addition, US scientists have drawn a hyperfine 3D mouse brain atlas, the map by a series of high-definition image mosaic, individual nerve cells in the nanometer scale never before visible.
The field of vaccine research and design: a number of research institutions and enterprises involved in the development of Ebola vaccine has been a period or completion of Phase II human clinical trials. University of Illinois at Urbana - Champaign by "genome mining" technology searched for 10,000 kinds of bacteria, with four years discovered 19 kinds of previously unknown natural phosphates new products, each of which is expected to become a potential new drugs, one of which has been confirmed as antibiotics.
Cancer research: The US Food and Drug Administration (FDA) approved the first treatment of melanoma and other cancers-viral drugs, and its core is the use of a modified engineering herpes virus, without harming healthy cells to kill destroy cancer cells, and trigger anti-cancer immune response in the human body; the University of Texas Southwestern Medical Center found that whole-genome sequencing can identify cancer risk cancer family background of the crowd, to improve the diagnosis of genetic variation in the ability of cancerous tendency; Harvard University use Stimulated Raman Scattering (SRS) microscopy techniques, without fluorescently labeled molecular mechanism that is observed in vivo skin cell division process, DNA, cells can interfere with normal development without understanding the extent of the cancer cells.
AIDS Study: Gene therapy based on "strong" new drug eCD4-Ig can prevent a variety of known strains of HIV infection, rhesus monkey tests showed its effectiveness is much higher than existing best broad-spectrum anti- Ai drugs. The new drug by pretending the virus "shut out" - cause the body to produce two kinds of receptors CD4 and CCR5 "cottage" goods, "spoofing" the AIDS virus binds, thereby losing the opportunity for the virus to enter the body. US researchers have developed a probe called "molecular microscope", it is possible to accurately detect the AIDS virus hides in the land of intracellular ultimately can help clarify the AIDS virus for a long time remaining answers, so as to be completely from the body Clear.
Basic medical research areas: US researchers have found that a key component of one associated with depression - fibroblast growth factor 9 (FGF9) protein and its content in the brains of patients with depression is much higher than non-depressed patients; Northwestern University Researchers studying nematode found that when the animals reach reproductive maturity, a genetic switch will open the aging process, but also protect the body from aging; Johns Hopkins University found that a magnetic separation column containing magnetic nanoparticles means to accelerate the generation of T cells, whose ultimate goal is to train T cells in the patient's blood sample and to increase their number, and finally put them back in the patient's body, the device helps to knock on the door of immunotherapy; the University of California San Francisco using gene editing technology CRISPR / Cas9 precise modification of human T cells; Harvard Medical School to capture the pigs to become one of the biggest difficulties of human organ donors - sever porcine endogenous retroviruses in vivo re-transplant recipients the possibility of activation, is expected to make the pig organ donor to become human.
Aspects of synthetic biology: Duke University researchers used biopsy cells, for the first time in the laboratory to produce a can shrink and respond to external stimuli human skeletal muscle, it can be like natural human tissues to external electrical pulses and pharmaceuticals to stimulate the biochemical signals make the same reaction; MGH researchers used acellular technology to create a method of constructing artificial biological limbs and blood vessels and have successfully bred a mouse forelimb muscle tissue; University of Illinois at Chicago and Northwestern University developed An artificial ribosome, they can be as natural as ribosomes in the cell to produce proteins and enzymes for the production of new drugs and the next generation of biological material and understanding the ribosome function provides assistance; Stanford University to create a flexible, can change color The pressure-sensitive material, touching the intensity is different, the color will change with, become the closest date chameleon skin of synthetic material; US scientists first bred with human cells can sound artificial vocal cord tissue, animal experiments show that the organization able to grow normally and did not elicit an immune response, which offers hope to patients who have lost the vocal cords; US researchers extracted stem cells from human skin more genetic recombination, and encouraged a owner of micro-ventricular heart cells, this " little heart "can be as heart beating like a full-size, can replace animal experiments which, screening new drugs or testing drugs affect the baby.
Brain research has made new achievements, medicine and disease prevention has made a number of major breakthroughs in synthetic biology achievement scene.
Subject Field (newspaper reporter stationed in the United States) in 2015, American scientists made a major breakthrough in the field of brain research: in August, Ohio State University to breed almost fully formed human brain in the laboratory, although it has only a pencil eraser then large, the degree of development and a 5-week-old fetal brain quite, yet there is no awareness, but with the vast majority of cell types and brain function, and can be like the human brain gene expression, using it can help scientists to test new drugs and more more understanding of the disease mechanisms of the brain; in September, the University of Washington research team completed the most complex human brain directly connected experiments, they used a brain - brain directly connected, so five pairs of subjects brain signals transmitted via the Internet to play Answers game. This trial was the first proof of two brain can be connected directly, and without sound, one can accurately guess the other ideas. In addition, US scientists have drawn a hyperfine 3D mouse brain atlas, the map by a series of high-definition image mosaic, individual nerve cells in the nanometer scale never before visible.
The field of vaccine research and design: a number of research institutions and enterprises involved in the development of Ebola vaccine has been a period or completion of Phase II human clinical trials. University of Illinois at Urbana - Champaign by "genome mining" technology searched for 10,000 kinds of bacteria, with four years discovered 19 kinds of previously unknown natural phosphates new products, each of which is expected to become a potential new drugs, one of which has been confirmed as antibiotics.
Cancer research: The US Food and Drug Administration (FDA) approved the first treatment of melanoma and other cancers-viral drugs, and its core is the use of a modified engineering herpes virus, without harming healthy cells to kill destroy cancer cells, and trigger anti-cancer immune response in the human body; the University of Texas Southwestern Medical Center found that whole-genome sequencing can identify cancer risk cancer family background of the crowd, to improve the diagnosis of genetic variation in the ability of cancerous tendency; Harvard University use Stimulated Raman Scattering (SRS) microscopy techniques, without fluorescently labeled molecular mechanism that is observed in vivo skin cell division process, DNA, cells can interfere with normal development without understanding the extent of the cancer cells.
AIDS Study: Gene therapy based on "strong" new drug eCD4-Ig can prevent a variety of known strains of HIV infection, rhesus monkey tests showed its effectiveness is much higher than existing best broad-spectrum anti- Ai drugs. The new drug by pretending the virus "shut out" - cause the body to produce two kinds of receptors CD4 and CCR5 "cottage" goods, "spoofing" the AIDS virus binds, thereby losing the opportunity for the virus to enter the body. US researchers have developed a probe called "molecular microscope", it is possible to accurately detect the AIDS virus hides in the land of intracellular ultimately can help clarify the AIDS virus for a long time remaining answers, so as to be completely from the body Clear.
Basic medical research areas: US researchers have found that a key component of one associated with depression - fibroblast growth factor 9 (FGF9) protein and its content in the brains of patients with depression is much higher than non-depressed patients; Northwestern University Researchers studying nematode found that when the animals reach reproductive maturity, a genetic switch will open the aging process, but also protect the body from aging; Johns Hopkins University found that a magnetic separation column containing magnetic nanoparticles means to accelerate the generation of T cells, whose ultimate goal is to train T cells in the patient's blood sample and to increase their number, and finally put them back in the patient's body, the device helps to knock on the door of immunotherapy; the University of California San Francisco using gene editing technology CRISPR / Cas9 precise modification of human T cells; Harvard Medical School to capture the pigs to become one of the biggest difficulties of human organ donors - sever porcine endogenous retroviruses in vivo re-transplant recipients the possibility of activation, is expected to make the pig organ donor to become human.
Aspects of synthetic biology: Duke University researchers used biopsy cells, for the first time in the laboratory to produce a can shrink and respond to external stimuli human skeletal muscle, it can be like natural human tissues to external electrical pulses and pharmaceuticals to stimulate the biochemical signals make the same reaction; MGH researchers used acellular technology to create a method of constructing artificial biological limbs and blood vessels and have successfully bred a mouse forelimb muscle tissue; University of Illinois at Chicago and Northwestern University developed An artificial ribosome, they can be as natural as ribosomes in the cell to produce proteins and enzymes for the production of new drugs and the next generation of biological material and understanding the ribosome function provides assistance; Stanford University to create a flexible, can change color The pressure-sensitive material, touching the intensity is different, the color will change with, become the closest date chameleon skin of synthetic material; US scientists first bred with human cells can sound artificial vocal cord tissue, animal experiments show that the organization able to grow normally and did not elicit an immune response, which offers hope to patients who have lost the vocal cords; US researchers extracted stem cells from human skin more genetic recombination, and encouraged a owner of micro-ventricular heart cells, this " little heart "can be as heart beating like a full-size, can replace animal experiments which, screening new drugs or testing drugs affect the baby.
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