Pfizer and Merck today announced that the two parties since January 1, 2016 Pfizer formal joint promotion targeting cancer drugs Sai Rui ® (g azole erlotinib) in Chinese market. This is an important strategic move in August 2015, Pfizer and Merck, a global strategic alliance official visit in China after. This will combine Pfizer and Merck Medical Resources, innovative experiences and professional team in China, so that more Chinese ALK-positive non-small cell lung cancer (NSCLC) patients benefit, and continue to promote the development of China in the field of cancer therapy immunity.
"Sai Rui ® joint promotion is a global alliance with Merck, Pfizer landing in China," the head of one of the joint promotion - president of Pfizer tumor Greater single country Ang said, "the significance of this cooperation is to He began to focus on the resources and strengths of both companies to maximize the benefit of Chinese cancer patients in China to promote the field of oncology and immunology latest targeted therapy oncology drugs faster, better and more widely available so that patients have access to timely, accurate diagnosis and treatment. of this strategic cooperation, the joint promotion is just the beginning, we believe that in the future, except for lung cancer drugs, there will be more and tumor-related products in the Chinese market, so that more Chinese Cancer patients benefit. "
2016年1月12日星期二
2016年1月11日星期一
Well I want eternal youth? So many children now!
Scientists from Simon Fraser University in Canada through the study found that the number of children or aging can affect the female body, research published in the international journal PLoS ONE.
Article, the researchers found, can give birth to more children surviving female body contains long telomeres, telomeres protect the ends of the ends of the DNA, but also an indicator of body cell aging, longer telomeres for At the same time it is also essential for cell replication and the body is directly related to longevity.
In this paper, the researchers on two adjacent local rural communities in Guatemala 75 women carried out relevant research, investigated the association of participants and the number of children born between telomere length, the researchers through the saliva samples and the chamber within wipes analysis, separated by 13 years in the two time points in telomere length were measured participants, this study is the first analysis of the number of direct relevance children between telomere shortening and body.
In this paper, a speculation denied before, namely that the more the number of children women would accelerate biological aging trajectory Nepomnaschy researchers said, but we found that telomere shortening rate of children in female organism more slowly This may depend on the dramatic increase in women during pregnancy produced due to estrogen, and estrogen can be used as a potential antioxidant to protect cells from telomere shortening.
The researchers also explained that participants in the social environment may also affect their fertility association between effectiveness and the aging process, the researchers tracked in the article are from the group of women with a natural fertility, that fertility more mother often received from relatives and friends more social support, a lot of support will increase female body's energy metabolism, thus can maintain the body's tissues, and thus slow down the aging body; of course researchers also hope that through the latter part of a large number of studies are needed to elucidate the molecular mechanisms behind this phenomenon.
Article, the researchers found, can give birth to more children surviving female body contains long telomeres, telomeres protect the ends of the ends of the DNA, but also an indicator of body cell aging, longer telomeres for At the same time it is also essential for cell replication and the body is directly related to longevity.
In this paper, the researchers on two adjacent local rural communities in Guatemala 75 women carried out relevant research, investigated the association of participants and the number of children born between telomere length, the researchers through the saliva samples and the chamber within wipes analysis, separated by 13 years in the two time points in telomere length were measured participants, this study is the first analysis of the number of direct relevance children between telomere shortening and body.
In this paper, a speculation denied before, namely that the more the number of children women would accelerate biological aging trajectory Nepomnaschy researchers said, but we found that telomere shortening rate of children in female organism more slowly This may depend on the dramatic increase in women during pregnancy produced due to estrogen, and estrogen can be used as a potential antioxidant to protect cells from telomere shortening.
The researchers also explained that participants in the social environment may also affect their fertility association between effectiveness and the aging process, the researchers tracked in the article are from the group of women with a natural fertility, that fertility more mother often received from relatives and friends more social support, a lot of support will increase female body's energy metabolism, thus can maintain the body's tissues, and thus slow down the aging body; of course researchers also hope that through the latter part of a large number of studies are needed to elucidate the molecular mechanisms behind this phenomenon.
B-sitosterol
Product name:B-sitosterol
CAS:64997-52-0
Molecular Formula:C29H50O
Formula Weight:414.71
Description:β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. Sitosterols are white, waxy powders with a characteristic odor. They are hydrophobic and soluble in alcohols.
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The scientists used skin cells to successfully treat heart damage
After experiencing a heart attack or other heart trauma, heart can not effectively remove heart cell death, while heart transplantation transplant patients in addition to the treatment of choice almost rarely, a heart transplant is not very easy, recently researchers using cell The therapy of heart cells after transplantation into the damaged heart patients, but in most cases these cells were transplanted into the heart will not be good for growth after implantation, so that the possibility of the patient's heart will eventually recover greatly reduced.
One reason for the occurrence of migration issues is the quality of heart cells, in a typical cell therapy, cardiac cells usually come from different stem cells, but the quality of cardiac cells but it will not stop change; in particular, the process of maturation of heart cells is is not the same, but different mature cells are also used for transplant are mixed together; researchers from Kyoto University in Japan Shunsuke Funakoshi has carried out a new study to investigate heart cells for transplantation best maturation process, thus it for the successful development of effective cell therapy of heart problems provide some clues and ideas.
Under the guidance of the researcher Yoshinori Yoshida, Funakoshi skin cells to induce reprogramming of the formation from the pluripotent stem cells (iPS) operates to convert it into heart cells, and the differentiation of cardiac iPS cells can be efficiently through all developmental stage. The researchers said that the different stages of heart cells tend behavior is not the same, so we prepared a different maturity stages of heart cells and transplanted into the damaged hearts of mice in vivo, so 20 days to accept the mature heart cells by Loss of heart will preferably receive transplanted into heart cells, and this time is longer or shorter than the mature cardiac cells implanted is much better, which indicates a successful cell therapy to optimal cardiac cells mature stage is critical; the same researchers also said that transplant patients for different times and can not be determined by this study.
Currently undergoing human heart cell therapy takes about one billion cells, which cells specifically suited for the treatment can not only help improve the treatment and prognosis of patients, but also reduce the number of the cells need this for the future to effectively reduce unnecessary waste and the procedure brought some help and hope.
One reason for the occurrence of migration issues is the quality of heart cells, in a typical cell therapy, cardiac cells usually come from different stem cells, but the quality of cardiac cells but it will not stop change; in particular, the process of maturation of heart cells is is not the same, but different mature cells are also used for transplant are mixed together; researchers from Kyoto University in Japan Shunsuke Funakoshi has carried out a new study to investigate heart cells for transplantation best maturation process, thus it for the successful development of effective cell therapy of heart problems provide some clues and ideas.
Under the guidance of the researcher Yoshinori Yoshida, Funakoshi skin cells to induce reprogramming of the formation from the pluripotent stem cells (iPS) operates to convert it into heart cells, and the differentiation of cardiac iPS cells can be efficiently through all developmental stage. The researchers said that the different stages of heart cells tend behavior is not the same, so we prepared a different maturity stages of heart cells and transplanted into the damaged hearts of mice in vivo, so 20 days to accept the mature heart cells by Loss of heart will preferably receive transplanted into heart cells, and this time is longer or shorter than the mature cardiac cells implanted is much better, which indicates a successful cell therapy to optimal cardiac cells mature stage is critical; the same researchers also said that transplant patients for different times and can not be determined by this study.
Currently undergoing human heart cell therapy takes about one billion cells, which cells specifically suited for the treatment can not only help improve the treatment and prognosis of patients, but also reduce the number of the cells need this for the future to effectively reduce unnecessary waste and the procedure brought some help and hope.
Successful pregnancy may only need three genes on the male Y chromosome
Published in the international journal PLoS Genetics of a research report, researchers from the University of Hawaii Institute of biological origin by studying the Y chromosome genes uncovered the body of the new features; article by the researchers found that male mice only need 3 genes from the Y chromosome sperm can be manufactured, through microinjection (intracytoplasmic sperm injection, ICSI) with the egg after fertilization, and produce offspring.
Two years ago, the research team successfully obtained only male mice of the body 2 Y chromosome gene bred offspring of these two genes, called testis determining child Sry and spermatogonial proliferation factor Eif2s3y, these male mice do not produce sperm to completion of the fertilization process, the researchers had to use the body of mice immature precursor cells - sperm cells and a cytoplasmic sperm injection, called a spherical (round spermatid injections, ROSI) to study. The researchers believe that this technology called ROSI is an experimental step, but it has not been recommended as a treatment for male infertility treatments, but ICSI was widely used in the world, the use of ICSI technique bred tens annually million newborns.
Researchers believe that gene Y chromosome probably mainly responsible for the sperm cells into sperm; and with the results of a joint study from France, Britain and other multinational research staff, researchers hypothesize that a key gene on the Y chromosome may be Zfy2 ( encoding a zinc finger protein 2), then they will Zfy2 added to by transgenic methods already exist but Sry and Eif2s3y transgenic male mice deletion of the Y chromosome in the body, results showed that the three mouse Y chromosome carries genes will produce sperm, these male mice were not able to produce their own sperm, because of its low sperm levels. But when the researchers harvested sperm by the testes of mice which were injected into the egg can be a successful pregnancy, the embryo into a surrogate female mouse body after birth rate of young mice, as compared to the control group in terms of (carrying the normal Y mouse chromosomes).
Researchers Ward noted that the three Y chromosome-derived gene may be enough to help the body to produce functional sperm and then promote fertilization, ICSI technique is often used in human infertility therapy, this study found that the round sperm cells into sperm It is a critical process, but perhaps mediated gene Zfy2 an important regulator of the process, including sperm maturation and function of play.
Two years ago, the research team successfully obtained only male mice of the body 2 Y chromosome gene bred offspring of these two genes, called testis determining child Sry and spermatogonial proliferation factor Eif2s3y, these male mice do not produce sperm to completion of the fertilization process, the researchers had to use the body of mice immature precursor cells - sperm cells and a cytoplasmic sperm injection, called a spherical (round spermatid injections, ROSI) to study. The researchers believe that this technology called ROSI is an experimental step, but it has not been recommended as a treatment for male infertility treatments, but ICSI was widely used in the world, the use of ICSI technique bred tens annually million newborns.
Researchers believe that gene Y chromosome probably mainly responsible for the sperm cells into sperm; and with the results of a joint study from France, Britain and other multinational research staff, researchers hypothesize that a key gene on the Y chromosome may be Zfy2 ( encoding a zinc finger protein 2), then they will Zfy2 added to by transgenic methods already exist but Sry and Eif2s3y transgenic male mice deletion of the Y chromosome in the body, results showed that the three mouse Y chromosome carries genes will produce sperm, these male mice were not able to produce their own sperm, because of its low sperm levels. But when the researchers harvested sperm by the testes of mice which were injected into the egg can be a successful pregnancy, the embryo into a surrogate female mouse body after birth rate of young mice, as compared to the control group in terms of (carrying the normal Y mouse chromosomes).
Researchers Ward noted that the three Y chromosome-derived gene may be enough to help the body to produce functional sperm and then promote fertilization, ICSI technique is often used in human infertility therapy, this study found that the round sperm cells into sperm It is a critical process, but perhaps mediated gene Zfy2 an important regulator of the process, including sperm maturation and function of play.
Lappaconitine Hydrobromide
Product name:Lappaconitine Hydrobromide
CAS:97792-45-5
Molecular Weight:665.61g/mol
Molecular Formula:C32H45BrN2O8
Description:Production of lappaconitine hydrobromide is required for the clinical use of an effective domestic medicinal drug for preventing and treating cardiovacsular pathologies.It is implemented at the Experimental Chemical Production of the Vorozhtsov Novosibirsk Institute of Organic Chemistry (NIOC), SB RAS.
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Alkyl dimethyl benzyl ammonium chloride
Product name:Alkyl dimethyl benzyl ammonium chloride
CAS:8001-54-5
Molecular Formula:C17H30ClN
Molecular Weight:283.88g/mol
Description:Benzalkonium chloride, also known as alkyldimethylbenzylammonium chloride and ADBAC, is a mixture of alkylbenzyldimethylammonium chlorides of various even-numbered alkyl chain lengths. This product is a nitrogenous cationic surface-acting agent belonging to the quaternary ammonium group. It has three main categories of use; as a biocide, a cationic surfactant and phase transfer agent in the chemical industry.
from:http://www.chemicalspharm.com/New-Products/Alkyl-dimethyl-benzyl-ammonium-chloride/
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