2016年1月13日星期三

4-Amino-3-phenylbutyric acid hydrochloride

CAS:1078-21-3
Molecular Formula:C10H14ClNO2
Molecular Weight:215.68g/mol
Description:White crystalline powder.
            Assay:≥99.0%
             pH:2.3 ~ 2.7
            Loss on Drying:≤0.5%
            Heavy Metals:≤10ppm
            Sulphate: ≤0.05%
            Molysite: ≤60ppm(1g/ml)

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Alveolar neuroendocrine cells regulate local immune response mechanism

In the resting state, the body of the air out of the lungs are about 5-8 liters per minute, which contain large quantities of allergenic substances. These signals can be the surface of the lungs cell recognition and transfer trigger a series of physiological responses, including pulmonary blood pressure, immune response, respiratory rhythm, etc., but in which the mechanism is not clear. Pulmonary neuroendocrine cells are present in the lungs of a cell type, accounting for 1% of all epidermal cells. In vitro studies indicated that the previous PNEC for feelings of oxygen, the lungs and the bronchial smooth muscle of the organization as well as the immune response plays an important role, but there has been a lack of evidence in the body. Some clinical evidence suggests that common diseases of the lungs, such as asthma, cystic fibrosis and poor trachea development, etc., are accompanied by a rise in the number PNEC, but the causal relationship is not clear.

In the lungs of mice, PNEC generally 20-30 cells distributed in clusters called neuroepithelial bodies, they generally like structures form vesicles, filled with biologically active neuropeptides. Previous studies have shown that these neuropeptides are likely to participate in physical activity PNEC, which, from the University of Wisconsin - Xin Sun Madison campus group conducted a detailed study. Relevant results published in the "science" the latest issue of the magazine.

Cefcapene pivoxil for sale


Product name: Cefcapene pivoxil
CAS no.: 
105889-45-0
Molecular Formula: C23H29N5O8S2 
Molecular Weight: 
567.64 
Product description: Drug of the class of the drug. For the precursor drugs, dissociation into free acid and play a role, can be orally.

from:http://www.chemicalspharm.com/New-Products/Cefcapene-pivoxil/

Betaxolol hydrochloride


Product name:Betaxolol hydrochloride
CAS
: 63659-19-8
Molecular Formula: C18H30ClNO3
Molecular Weight: 343.89
Product description:Selective beta 1 receptor blocker, no inner fitting the sympathetic activity and membrane stability. For beta 1 receptor selectivity than atenolol and thor slightly higher. To the action of the heart and other beta blockers. The blood vessels and the effect of bronchial smooth muscle is weak. Also can reduce the plasma renin activity.Suitable for the treatment of chronic primary open-angle glaucoma, high intraocular pressure; Is required for a high intraocular pressure caused by primary closed-angle glaucoma with eye medicine.

From:http://www.acridine-raw-material.com/Pharmaceutical-APIS/Betaxolol-hydrochloride/
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Dimethyl-D-tartrate


Product name:Dimethyl-D-tartrate
CAS: 13171-64-7
Molecular Formula:C6H10O6
Formula Weight:178.14
Description:
Melting point:48-50 ºC
Boiling point:157-159 ºC (11 mmHg),280 °C at 760 mmHg
Flash Point:95.7 °C
Density:1.367 g/cm3
Chemical property:White mass solid or colorless oil-like liquid
Use:Used mainly for chiral drugs 
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Women scientists to funding more difficult to apply?

Women scientists from the American government to apply for research funding will be less than their male counterparts do? The earliest a cross-sectoral survey: sometimes true. However, the Government Accountability Office (GAO) raised some objections: because some agencies did not get the necessary data before making conclusions, GAO hopes to find new ways to figure out this problem - this is the three Democratic Women MPs requirements; In addition, even the existence of differences in terms of grant applications, but may not lead to discrimination due to gender; and finally, some of the IMF did not follow the strict legal requirements to track major colleges and universities in the allocation of funds in compliance with the principle of gender equality .

GAO wish success rate in grant applications as indicators of whether women receive different treatment. It is collected from 2009 to 2013 to study funded by six IMF (ranging from basic research to applied research, from theoretical science to engineering sciences, etc., account for 90% of the entire US research funding) application data. The results show: the two largest IMF: NIH and NSF, the female and male scientist in the grant application success rates are similar.

But there are also bad news: the data Energy Sciences Office of the Defense Office of Naval given, the success rate of male funding applications 7% and 6%, respectively, than women. But because the two institutions are not systematically collect the applicant's materials, it is difficult to directly answer whether there is gender discrimination.

However, the lack of data is not blocked GAO determination. They NSF conducted "Dr. survey respondents' questionnaire results are analyzed, the survey data on the sources of funding include nearly one million scientists and engineers have their own submission. These data can provide information on whether they are subject to gender-based discrimination in accepting funding from NIH, NSF, DOE and DOD and other agencies.

Overall data show that: women scientists in NIH funding by one-third more than the men. However, DOE, women get funded only one-third of men.

GAO believes that the main reason for this difference is the difference between the applicant group. Women researchers focused on the biomedical field, but relatively few physical sciences and engineering fields related to DOE and DOD support. This makes women in NIH, NSF range is funded within rather than men.
Bolise Co., Ltd.

HCCLM3


Product name:HCCLM3
Species:Human

Source:Liver cancer, lung metastases

Morphology: Epithelial

Medium and additives:DMEM and 10% fetal bovine serum

Application:Only for research purposes

Product description:
This is the employing hepatoma cell line MHCC97-H inoculated in nude mice, conducting three times lung metastasis screening,and the completion of the lung metastases were inoculated subcutaneously with a high degree of spontaneous lung metastasis after liver cancer cell lines.

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