MTB mediated hyperthermia or inhibit resistant bacterial infections

With Staphylococcus aureus resistance to antibiotics is growing, scientists urgently need to develop new ways to effectively kill the resistant strains, a recently published in the International Journal of Applied and Environmental Microbiology research papers , researchers from the Chinese Academy of Sciences conducted experiments in rodents, by using a magnetic nanocrystals generate excessive heat (hyperthermia) so as to target kill Staphylococcus aureus.

Specific bacteria, such as MTB MO-1 (Magnetooliva massalia strain MO-1) can be synthesized in the cell magnetic nanocrystals, namely magnetic body (Magnetosomes), when it is placed in a variable magnetic field is generated when the heat; researchers in a particular field can guide the bacteria deep into the affected area to exert a therapeutic effect, of course, the heat generated by the magnetic crystals can not only kill Staphylococcus aureus, which can also kill the bacteria contain nanoparticles, so magnetotactic bacteria (magnetotactic bacteria) or as a "suicide bomb" to effectively kill the resistant bacteria.

For this study, researchers found that MTB can inhibit Staphylococcus aureus infections, and also its interaction with the magnetic field changes the role of raising the temperature to 43 degrees, while the temperature is sufficient to kill the bacteria. More importantly, researchers will increasingly mediated bacterial magnetic hyperthermia applied to the tails of mice infected with Staphylococcus aureus, showed that compared to not accept the terms of the high heat-treated mice, the high heat can accelerate wound Mice heal.

Then researchers MTB cell surface polyclonal antibody was engineered to operate, these antibodies can bind to Staphylococcus aureus MTB can not adsorb other bacteria, when MTB combined with Staphylococcus aureus, magnetic particles tend to produce excessive heat will kill pathogens, and less damage to healthy tissue. Now researchers are investigating the mechanism of action of magnetic trend, they want research to clarify how bacteria interact with the magnetic moment and the magnetic moment of how to transform bacteria formed to guide the movement of biochemical signals.

Finally, the researchers said Song Tao, the magnetic particles are increasingly targeted for treatment of tumors or infected tissues

Dutasteride

A synthetic connection 4-asteroid. Dutasteride competitive and specific form of isoenzymes 1 and 2 of the 5-alpha-reductase enzyme complex stable, and by inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); The reduction in DHT activity can reduce prostate enlargement or prevented. The isoenzyme 2-5-alpha-reductase type is primarily in reproductive tissues, while the type 1 isozyme is also active in the skin and liver.

Saxitoxin

Product name:Saxitoxin

CAS:35523-89-8

Molecular Formula:C10H17N7O4

Molecular Weight:299.29g/mol

Description:Saxitoxin (STX) is a neurotoxin naturally produced by certain species of marine dinoflagellates.It is one of the most potent natural toxins known, acts on the voltage-gated sodium channels of nerve cells, preventing normal cellular function and leading to paralysis. The term saxitoxin can also refer to the entire suite of related neurotoxins produced by these microorganisms, which include pure saxitoxin (STX), neosaxitoxin (neoSTX), the gonyautoxins (GTX) and decarbamoylsaxitoxin (dcSTX).

Intestinal Epithelial Cell Line 6

BACKGROUND AND OBJECTIVES:
Corticosteroids are anti-inflammatory drugs commonly used to treat inflammatory bowel disease, but do not benefit many patients of steroid (glucocorticoid resistance) or the needs of inappropriately high doses remission (glucocorticoid-dependent) to hold. Because of the role of intestinal epithelial cells in inflammatory bowel disease, we looked for the signaling of the glucocorticoid receptor and the effect of interleukin-1 beta as one of the most important pro-inflammatory cytokines in the intestinal cell epithelial IEC-6 and Caco-2.
methods:
effect of dexamethasone on activation of transcription containing glucocorticoid response elements was reporter assay using a measured construction. The effect was transrepression of nuclear factor (NF) kappaB inducible reporter construct monitored. was also used in IEC-6 cells immunocytochemistry glucocorticoid receptor translocation to be monitored.
RESULTS:
reporter gene mediated by the receptor and translocation of the receiver, the effects of dexamethasone on interleukin-1 beta significantly inhibited induced by dexamethasone. Dexamethasone inhibited interleukin-1 beta induces the transcription of NF-kappaB gene driven only in IEC-6 and not in Caco-2 cells. However, in Caco-2 cells overexpressing the glucocorticoid receptor resulted in a significant decrease in the activity of NF-kappa B, even in the absence of dexamethasone.
CONCLUSION:
These studies demonstrate that gene regulation of glucocorticoid receptors leads in the epithelial cells of the intestine contribute to the anti-inflammatory action of glucocorticoids in inflammatory bowel disease. The data are consistent with the notion that interleukin-1 beta in the resistance induced by the inflammatory reaction produced of steroids, which, in the treatment of patients with inflammatory bowel disease is a clinical problem current.

L-Cystathionine

Product Name:L-Cystathionine

CAS:56-88-2

Molecular Formula:C7H14N2O4S

Molecular Weight:222.2621

Description:InChI=1/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5+/m1/s1

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Cefoxitin sodium for sale

Product name:Cefoxitin sodium
CAS no.:33564-30-6 
Molecular Formula:C16H16N3NaO7S2
Molecular Weight:449.4339 
Appearance:White crystalline powder
Purity:≥99%
Product description:Mainly used for infection caused by sensitive bacteria of respiratory tract infections, endocarditis, peritonitis, pyelonephritis, urinary tract infection, septicemia and bone, joints, skin and soft tissue etc..
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Stem cell therapy to humans by a cat

When the kitten Bob came to the University of California at Davis veterinary hospital, it has exhausted its nine lives; inflammation of the mouth due to the torture, Bob has been pulled all the teeth and trying to name this cat class chronic gingivostomatitis (FCGS) the fight against the disease, and finally Bob into a small clinical trial to accept a new type of stem cell therapy for treatment. Bob and other small cat as a very fortunate to enter into this clinical trial, the test was a success, Bob gained a new life.

The results of this study the researchers published in the journal Stem Cells Translational Medicine; articles first time, researchers using stem cell therapy successful and effective in the treatment of feline chronic gingivostomatitis disease; Arzi when researchers saw a lot due to treatment chronic gingivostomatitis lost all teeth cat, he opened a special treat feline disease clinical trials; feline chronic gingivostomatitis is a difficult to treat disease, researchers often see some of the cats the traditional therapy and nothing happens, so they decided to use stem cell therapy to try; first they use a cat body's own fat-derived stem cells, stem cell processing and characterizing followed then these treated stem cells cats intravenous injection to reduce the body's inflammatory cat show, and promote tissue regeneration; researchers also identified a useful biomarker, which can help determine whether the cat will react to stem cell therapy.

Arzi said, the first time we use this new technology to test mammal as an animal disease, feline chronic gingivostomatitis disease might be able to, as a new model to help develop effective treatment of human chronic inflammatory diseases of the oral cavity new therapies.

Researchers Nasim Fazel previous relevant studies organization feline chronic gingivostomatitis chronic stomatitis and human diseases and pathology characteristic of inflammatory markers in the blood. Oral lichen planus is a similar feline chronic gingivostomatitis T cell-mediated chronic inflammatory mucosal diseases, Fazel said we are pleased that the disease has made a breakthrough, because the performance of cats with the disease oral lichen planus human pathology is very similar, based on the above research, the current researchers have submitted an application to establish human clinical trials, between the use of mesenchymal stem cell therapy to treat human OLP, believed by researchers late tireless efforts of their research in this field will make new research results.