This gene encodes a member of the family of the corticotropin releasing factor. Encoded preprotein proteolysis to generate the mature neuropeptide hormone treated. In response to stress, this hormone by the paraventricular nucleus (PVN) of the hypothalamus is secreted, binds releasing hormone receptors and stimulates the release of corticotropin from the pituitary ACTH. significant reduction of this protein was observed with regard to Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus of this protein will be synthesized in peripheral tissues, such as T cells and is highly expressed in the placenta. In the placenta, it is a marker that determines the duration of pregnancy and the date of delivery and the delivery. A rapid increase in the rate of circulating hormone occurs at the beginning of the birth, suggesting that in addition to this protein acts as a trigger for calving in its metabolic functions.
