FG-2216

Product name:FG-2216

Description:A new drug called FG-2216 can stimulate production of the hormone erythropoietin (EPO) in dialysis patients—possibly offering a new approach to treatment of kidney disease-related anemia, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Methylone

Molecular Formula:C11H13NO3

Molecular Weight:207.23g/mol

Description:Methylone, also known as "M1", 3,4-methylenedioxy-N-methylcathinone, bk-MDMA, MDMC, and in the UK as Arlone, is an entactogen and stimulant of the phenethylamine, amphetamine, and cathinone classes.It is a close structural analogue of MDMA, differing by the addition of a β-ketone group.

from:http://www.chemicalspharm.com/New-Products/Methylone-/

Win-35428 origin

First proposed segregation fractionation column (CFT) of Clark and colleagues in 1973. As we all know, the tentacles of this drug to the top played a "positive reinforcement." Is often used tritium CFT new MAP binding ligand DAT although this drug, There are also some SERT affinity.

Concrete filled steel tube formed radiolabeled dopamine transporter medicament for human and animal distribution in brain CFT. The method is particularly suitable for the present application fluoro normal may be substituted widely used radioisotope 18F positron emission tomography other radioisotopes substituted analog won 35,428 carbon atoms (wherein N-methyl, or methyl 2-methyl ester groups from steel concrete, instead of 11C) document is now more commonly used in this application, because it can be faster and more convenient radiolabeled form concepts by methylation CFT get CFTCFT to go to, or 2-methyl-response than methylecgonidineparafluorophenylmagnesium and bromine, and also to avoid the scope of the requirements, including the manufacture, import, sale, retail, restricted precursor and ecgonine.

CFT addictive cocaine in animal studies, but because of how small a manner similar to cocaine longer duration of action, which potentially can turn it into a suitable pharmaceutical alternatives to the use of methadone in place of softwood bleached kraft pulp (opiates in addiction treatment.

from:https://en.wikipedia.org/wiki/WIN_35428

Scientists found that the "ultimate" antibiotic resistance genes

Bacteria worldwide are resistant to colistin there is a - a kind of "ultimate" antibiotic - genes. Related findings from China in November, followed by Denmark, the Netherlands, France and Thailand also found similar resistance genes.

Although this discovery worrying, but they may not like a lot of media coverage that would have disastrous consequences, since only one of several colistin dosage in humans is very rare antibiotics. The discovery "has brought very bad news, but not apocalyptic," American University of Utah, Salt Lake City, Dr. Makoto Jones said infectious disease.

Colistin was developed in the 1950s and is a polymyxin compounds. It has the title of "ultimate" of drugs, doctors will avoid as much as possible the use of this drug, because it can damage the patient's kidneys, University of Washington epidemiologist Lance Price said.

Therefore, compared with other antibiotics, the bacteria difficult to colistin resistance.

In fact, there have been previous reports of colistin-resistant mutations. Many soil bacteria are its resistance, because the drug is widely used in agriculture, long fat pigs, farm animals and prevent illness. In China, the amount of colistin is particularly high, the annual amount of applied agricultural sector reached 12,000 tons.

The latest findings show that colistin resistance gene is present in a loop of DNA called plasmids, and among bacteria already in the "share" of this resistance gene. Chinese researchers found E. coli in a sample of more than one province is called mcr-1 gene, indicating that the gene can spread easily; the same resistance gene have been found in Asia, Europe. Danish researchers have found that E. coli resistance can be passed to other unrelated bacteria.

The researchers said that the emergence of existing antibiotics can not treat bacterial infections but sooner or later. The US Food and Drug Administration in the past two years has approved several new antibiotics, of which there are more than 30 kinds of antibiotics being reviewed. But a lot of antibiotics, similar features and existing drugs, and does not produce better results.

Gene mutation? Gene filtering tools appeared

Although mutations always have a bad reputation, but a large number of mutations in perhaps not harmful; even in the very rare genetic disorder, only in the tens of thousands of genes in one or both mutations will actually caused diseases, and therefore distinguish harmful and beneficial mutation has been the focus of scientific research.

Scientists from Rockefeller University recently in Proceedings of the National Academy of the Sciences magazine published its latest research results, the article in which they developed a new tool designed to help predict whether a given human genes may contain promote disease mutation, the researchers hope the tool can help them a lot of genetic screening to help predict the occurrence of human diseases.

Yuval Itan researchers said, to get the first needle in a haystack also sucked seawater, while filtering out extraneous "noise" on key genes want to study clearly visible; by genomic analysis, the researchers found that 58 percent of rare mutations Located two percent of human genes, and they developed called Gene Damage Index (genetic damage index) tools can help infer, frequently mutated gene in the general population and perhaps less likely to lead to hereditary and the rarity of the disease , because these mutations in healthy individuals will frequently occur.

Such genetic damage index of tools that can help reveal a mutation occurs in the general population in the number of genes, or mutations accumulate damage, while the corresponding record the results may illustrate the importance of a particular gene on a given disease groups, such as cancer, Bangladesh Del's disease, autism and primary immune deficiency and the like. Finally, the researchers said, the use of this new tool you can weed out the 60% non-associated mutations, and genetic damage index tools will also help scientists to more easily obtain a large number of next-generation sequencing data analysis.

L-Ornithine L-Aspartate

BACKGROUND / AIMS: In the current knowledge of the pathophysiology of hepatic encephalopathy, a reduction of hyperammonemia is the most important evidence for effective treatment. Therefore, the therapeutic efficacy of oral L-ornithine L-aspartate, ammonia detoxification with improved faculties studied in patients with cirrhosis, hyperammonemia and stable, open chronic hepatic encephalopathy and subclinical hepatic encephalopathy in a randomized , double-blind, placebo-controlled clinical trial.

Methods: Oral L-ornithine L-aspartate was administered three times daily at fixed times for 14 consecutive days in a total dose of 18 g per day. The design has been chosen to increase the ammonia can be induced by a protein powder, 0.25 g / kg body weight administered daily to prevent the start of the treatment period. Efficacy variables were: fasting and postprandial ammonia concentration, number connection test time, mental state and qualities of an index of portosystemic encephalopathy. The analyzes were performed on the total population of the study and placebo 32 34 L-ornithine L-aspartate treated patients and the sub-groups of samples in the open air (20 placebo and 23 L-ornithine L-aspartate treaties) on the base and subclinical hepatic encephalopathy (12 placebo and 11 L-ornithine L-aspartate) treated patients.

Results: connection test performance time at (p <0.01) and fasting (p <0.01) and postprandial (p <0.05) showed venous blood ammonia concentrations in the group L-aspartate-L-ornithine treated an improvement relative to placebo. In addition, the mental state level (p <0.05) and the index of portosystemic encephalopathy (p <0.01) significantly improved in group L-aspartate L-ornithine as in the placebo group. Side effects have been observed in placebo patients or L-aspartate-treated L-ornithine.

Calcium-alpha-ketoglutarate

Product name:Calcium-alpha-ketoglutarate 
CAS:51828-96-7
Molecular formula:C5H4CaO5•H2O 
Molecular weight:327
Product description: Calcium-alpha-ketoglutarate  is a mineral calcium in a special form to help normalize concentrations of ordinary calcium in the body. Calcium-alpha-ketoglutarate eliminates excess phosphate in the blood by binding to it and passed into waste. This helps re-establish the balance between calcium and phosphate in your body.

from:http://www.chemicalspharm.com/products/Pharmaceutical-Intermediates/5271/