2016年1月31日星期日

Solutol HS 15

Product name:Solutol HS 15
Description:Solutol HS 15 is a yellowish white paste at room temperature that becomes liquid at approx. 30°C.It dissolves in water, ethanol and 2-propanol to form clear solutions.
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Ketotifen for sale

Product name:Ketotifen 
CAS:34580-13-7
Molecular Formula:C19H19NOS
Molecular Weight:309.43g/mol
Description:Ketotifen is an antihistimine that inhibits down regulation of beta receptors, which are often degraded by fat-burners such as Albuterol and Clenbuterol.
From:http://www.chemicalspharm.com/New-Products/Ketotifen--/
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Corallina officinalis extract

Description:From red algae, is rich in clacium and magnesium. Helps increase oxygen consumption and microcirculation.It is a vegetal coral-mineral rich red algae that helps reinforce the moisture barrier function of skin.
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Tinoderm A for sale

Product name:Tinoderm A
Description:Tinoderm A is a vitamin A precursor (retinyl palmitate) which is encapsulated in Tinoderm Nanotopes, our exclusive delivery system . The precursor is delivered into the skin, where it is converted to Vitamin A –which reduces the appearance of fine lines, age spots and wrinkles.
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How to buy S-Adenosyl-L-methionine


Product name:S-Adenosyl-L-methionine
CAS:29908-03-0
Molecular Formula:C15H24N6O5S
Formula Weight:400.45
Description:
 S-Adenosyl methionine (SAM, SAMe, SAM-e) is a common co-substrate involved in methyl group transfers.  Transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.[1]
The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins, and lipids.
In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.
From:http://www.acridine-raw-material.com/products/S-Adenosyl-L-methionine/
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2016年1月29日星期五

How to buy Elvitegravir


Product name:Elvitegravir

CAS
:697761-98-1

Molecular Formula:C23H23ClFNO5

Formula Weight:447.883g/mol

Description:Elvitegravir is an investigational new drug for the treatment of HIV infection. It acts as an integrase inhibitor.According to the results of the phase II clinical trial, patients taking once-daily elvitegravir boosted by ritonavir had greater reductions in viral load after 24 weeks compared to individuals randomized to receive a ritonavir-boosted protease inhibitor.
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2016年1月28日星期四

Ham's F10 & F12 for sale


Product name:Ham's F10 & F12
Specifications:500ml

Type:Primary cells

Product description:
F-10 Ham's Nutrient Mixture (F-10) was formulated for serum-free growth of Chinese Hamster Ovary cells and growth of various mammalian cell lines with serum supplementation.
F-12 Ham's Nutrient Mixture (F-12) was formulated for single-cell plating of near-diploid Chinese Hamster Ovary cells.
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Olivetol for sale

Product Name:Olivetol
CAS:500-66-3
Molecular Formula:C11H16O2
Molecular weight:180.2435
Description:5-Pentyl-1,3-benzenediol; 5-Pentylresorcinol; Pentyl-3,5-dihydroxybenzene; Oilvetol; n-Amylresolcinol; 5-Pentyl  3,5-Dihydroxyamylbenzene; 5-pentyl-3-benzenediol; 5-pentylbenzene-1,3-diol
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Phenothrin for sale


Product name:Phenothrin
CAS:26002-80-2
Molecular Formula:     C23H26O3
Formula Weight:     350.45
Description:
 Phenothrin, also called sumithrin, is a synthetic pyrethroid that kills adult fleas and ticks. It has also been used to kill head lice in humans. d-phenothrin is used as a component of aerosol insecticides for domestic use.
Phenothrin is often used with methoprene, an insect growth regulator that interrupts the insect's biological life cycle by killing the eggs.
In 2005, the EPA required Hartz Mountain Industries to cancel uses of several flea and tick products containing phenothrin that were linked to a range of adverse reactions, including hair loss, salivation, tremors, and numerous deaths in cats and kittens. In the short term, the agreement called for new warning labels on the products.
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Xanthoparmelia Scabrosa extract

Description:The herb Xanthoparmelia scabrosa, found in several male sexual enhancement products sold as Viagra .Medical research regarding xanthoparmelia scabrosa is difficult to find. Xanthoparmelia is a lichen found throughout the world .Xanthoparmelia has been promoted as an aphrodisiac. Scabrosin esters (SEs), which have been recently isolated from the lichen Xanthoparmelia scabrosa, belong to the epipolythiodioxopiperazine (ETP) class of secondary metabolites characterized by possession of a reactive disulfide bond.
From:http://www.chemicalspharm.com/New-Products/Xanthoparmelia-Scabrosa-extract/
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Acetylated oxidized starch

Description:Acetylated oxidized starch is a food and beverage ingredient used as a thickener.It is a chemically modified root or grain starch. It is produced by oxidation of a slurry of starch granules in alkaline hypochlorite at low temperature (21–38 °C). The alkaline medium is neutralized with sodium bisulfite, and the resulting organic salts are removed by washing with water. The oxidized starch is then esterified with acetic anhydride under mildly alkaline conditions.
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2016年1月27日星期三

Silver nanowires for sales

Product Name: silver nanowires
Description:
In addition to silver nanowires with excellent electrical conductivity of silver addition, due to the size effect of nano-level, but also has excellent transparency, resistance to flex. Therefore be regarded as the most likely alternative to the traditional ITO transparent electrode material for the realization of flexible, can bend the LED display, touch screen offers the possibility, and has a lot of research will be applied thin film solar cells. Furthermore, since the large aspect ratio of silver nanowires effect, so that theconductive adhesive, thermal plastic and other applications also have outstanding advantages.

Specification:
Average diameter: 100 ~ 200nm
Length: 10 ~ 20μm
Characters: dispersed in water or ethanol in the dispersion (the weight of solid content in real terms)

Pregabalin

Product Name:Pregabalin
CAS:148553-50-8
Molecular Formula:C8H17NO2
Molecular Weight:159.2261
Description:3-(aminomethyl)-5-methyl-hexanoic acid; Pregablin; (3S)-3-(aminomethyl)-5-methyl-hexanoic acid; (R-)-3-isobutyl GABA; 3-isobutyl GABA; CI 1008; CI-1008; Hexanoic acid; 3-(aminomethyl)-5-methyl-(3S)-Hexanoic acid; 3-(aminomethyl)-5-methyl-(S)-Lyrica; PD 144723; PD-144723; Pregabalin [USAN]; TOS-BB-0910; Pregabalin intermediate ; (3R)-3-(aminomethyl)-5-methylhexanoic acid
from:http://www.chemicals-chemicals.net/Intermediates/Pregabalin/

Epiandrosterone


Product name:Epiandrosterone
CAS: 481-29-8
Molecular Formula:     C19H30O2
Formula Weight:290.44
Description:
       Epiandrosterone is a steroid hormone with weak androgenic activity. It is a natural metabolite of dehydroepiandrosterone via the 5-alpha reductase enzyme. 
      Epiandrosterone has been shown to naturally occur in most mammals including pigs.
      Epiandrosterone is naturally produced by the enzyme 5-alpha reductase from the adrenal hormone dehydroepiandrosterone (DHEA).Epiandrosterone can also be converted from the natural steroids androstanediol via 17β-hydroxysteroid dehydrogenase or from androstanedione via 3β-hydroxysteroid dehydrogenase.
from:http://www.acridine-raw-material.com/products/Epiandrosterone/
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1,2,5-trihydroxybenzene


Product name:1,2,5-trihydroxybenzene
CAS:     108-73-6
Molecular Formula:     C6H6O3
Formula Weight:126.11
Description:
Melting point:215-220 °C
Boiling point:331.1 °C at 760 mmHg
Flash Point:174.9 °C
Density:1.488g/cm3
Chemical property:white to light yellow crystal
Storage:In ventilate,cool and dry places. 
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D-Pantoyl lactone


Product name:D-Pantoyl lactone
CAS:599-04-2
Molecular Formula:C6H10O3
Formula Weight:130.14
Description:
Melting point:91 °C(lit.)
Boiling point:120-122 °C15 mm Hg(lit.)
Flash Point:99°C
Density:1.165g/cm3
Appearance: White crystal powder.
Character: It dissolves easily in water, alcohol, methanol and propylene glycol.
Usage: The intermediate to produce D-panthenol and other composites.
Storage: to keep in the dry, off-light and ventilative place.
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Gamma Oryzanol


Product name:Gamma Oryzanol
CAS:
11042-64-1
Molecular Formula:C40H58O4
Formula Weight:602.89
Description:
Melting point:135-137 ºC
Boiling point:663.2 °C at 760 mmHg
Flash Point:193.8 °C
Density:1.1 g/cm3
Chemical property:White or white crystalline powder, odourless
                                   Soluble in acetone, chloroform, sparingly soluble in ethanol, n-heptane, insoluble in water.
Use:Used in Periodic mental disease,premenstrual tension,women's Menopause Syndrome and vascular headache etc.
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Vinylmagnesium bromide


Product name:Vinylmagnesium bromide
CAS:1826-67-1
Molecular Formula:C2H3BrMg
Formula Weight:131.25
Description:
Density:0.981 g/mL at 25 °C
Flash Point:-17 oC
Solubility:vigorous reaction.
Storage:Refrigerator.
Soubility:vigorous reaction
Use:Used as medicine intermediate.
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What is SelectFluoro


Replacement of hydrogen atoms by fluorine substituents into organic substrates is of great interest in synthetic chemistry due to the high electronegativity of fluorine and relatively small steric hindrance fluorine atoms. Many nucleophilic fluorine sources are available for the derivatization of organic molecules under acidic conditions, basic and neutral. However, electrophilic fluorination historically required molecular fluorine, whose notorious toxicity and explosive tendencies limit its application in research. The need for an electrophilic fluorination reagent, secure, stable, highly responsive and accessible to industrial production as an alternative, it is very hazardous molecular fluorine was the inspiration for the discovery of Select. This reagent is not only an electrophilic fluorination of available reagent, but it is also safe, non-toxic and easy to handle. In this article, we describe the many applications Select and discuss possible ways for its reaction.

9-bromo-1-nonanol


9-bromo-5-morpholino-tetrazole [1,5-c] quinoline cytotoxicity (BMT) is applied to the cell line L1210 murine leukemia and carcinoma cells of the Caco-2 colon. We have the two highest concentrations of BMTQ (149.2 and 74.6 microM) induces an acute cytotoxic effect, but other concentrations tested (<74.6 microM) exhibits a / dependent cytotoxic effect depending on the time and / concentration. The sensitivity of mouse leukemia L1210 cells and carcinoma cells of the Caco-2 colon was expressed in the same order. Cytotoxicity BMTQ not bound by changes in the cell cycle profile. After the effects of cytotoxicity associated BMTQ we observed induction of ssDNA breaks after BMTQ treatment. All BMTQ concentrations increases the level of ssDNA breeze 1.3-2.9 times (after 2 hours of treatment) and 1.6-2.8 times (after 4 hours of treatment) in Caco-2 cells compared to control. No apoptotic DNA fragmentation was induced by BMTQ in Caco-2 cells is recorded.

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2-butenoic acid for sale


Thirty-nine evaluable patients with squamous cell lung cancer treated with combination chemotherapy consisting of doxorubicin, Oncovin, bleomycin, cisplatin and cytembena. Objective responses were seen in 46 percent of patients. Patients with the disease had a rate of 56 percent response. Two of the four complete responses were verified endoscopically and histologically. The median survival was 37.6 and 26.3 weeks for patients with limited and extensive disease (p less than 0.05) and 29.9 weeks for the entire group. Haematological toxicities and gastrointestinal were moderate. There was a drug-related death due to sepsis and 2 reversible acute renal failure. The chemotherapeutic combination seems relatively effective. It causes a regression of the tumor, and possibly survival of responder patients with acceptable quality to increase. Maintenance chemotherapy with CCNU, cyclophosphamide, methotrexate, procarbazine be removed alternating with vinblastine, nitrogen mustard, methotrexate, procarbazine, often caused because of severe toxicity.

Piperazine ,1-(2-methylphenyl)-Hydrochloride


Some type of inverse agonists, cannabinoid receptor 1 (CB1) has been shown to be an anti-obesity appetite suppressant drug candidate. However, the first generation of CB1 inverse agonist rimonabant (SR141716A) is indicated taranabant otenabant and are centrally acting, with a high degree of psychiatric side effects. Therefore, the discovery of CB1 inverse agonists can be separated with a chemical backbone of these promising for the development of peripheral CB1 inverse agonist effective with fewer side effects. We generated a new CB1 inverse agonists (4- (bis (4-fluorophenyl) methyl) piperazin-1-yl) (cyclohexyl) methanone (LDK1229), from the class of the analogs of benzhydryl piperazine. This compound selectively binds to more than CB1 receptor cannabinoid type 2, with a Ki of 220 nM. CB1 comparable binding was also observed analogues of 1- [bis (4-fluorophenyl) methyl] -4-cinnamyl piperazine (LDK1203) and 1- [bis (4-fluorophenyl) methyl] -4-piperazine tosyl (LDK1222) represented by the substitution on the piperazine ring, where the piperazine and LDK1203 LDK1222 are each substituted with an alkyl shift and a tosyl group. LDK1229 has a comparable efficacy SR141716A antagonize the baseline activity of the G protein coupling CB1, as indicated by a reduction of guanosine 5'-O- (3-thio) triphosphate binding. In accordance with the inverse agonist behavior, increased CB1 location of the cell surface after treatment with LDK1229 was also observed. Although reception and mutation analysis showed that LDK1229 shapes similar interactions with the case of receptor SR141716A the benzhydryl piperazine skeleton structurally inverse agonists of first generation CB1 receptors. It offers new opportunities for the development of novel CB1 inverse agonists by optimizing the molecular properties, such as the polar surface and hydrophilic properties to reduce SR141716A observed with the core activity.

α-L-lyxo-Hexopyranoside, methyl 3-amino-2,3,6-trideoxy-, hydrochloride


Product name: α-L-lyxo-Hexopyranoside, methyl 3-amino-2,3,6-trideoxy-, hydrochloride 
CAS no.: 
32385-06-1 
Molecular Formula: C7H16ClNO3 
Molecular Weight: 
197.66 
Product description: Than the star like sugar intermediates.
From:http://www.chemicalspharm.com/New-Products/%CE%B1-L-lyxo-Hexopyranoside-methyl-3-amino-236-trideoxy--hydrochloride/

Carbamic acid

About Produts:
Molecular Formula: C21H28N2O3 
Molecular Weight: 
356.45862
Product description: Mira peron intermediate.
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CN-23 gaseous hydrocarbon steam reforming catalyst


Product name: CN-23 gaseous hydrocarbon steam reforming catalyst 
Category: Reforming Catalyst for Honeycomb-shaped & Tube-shell Heat Exchanged Reformer

Description: With nickel as the active component, alumina as the carrier, and rare earth oxide as the co-catalyst, CN-23 gaseous hydrocarbon steam reforming catalyst applies to the heat exchanged reformer in synthetic ammonia plant.
 

2016年1月26日星期二

New advances in brain sensor - wireless, soluble

Researchers from abroad have developed a wireless brain sensor that can monitor intracranial pressure and temperature, but also can be absorbed by the body, to reduce surgical removal of routine monitoring of equipment. The researchers pointed out that the implant as such can be used to monitor patients with traumatic brain injury, but they think we can build a similar sensor can be absorbed for monitoring activities in the organ systems throughout the body, research published in the International the magazine Nature.

Researchers Rory KJ Murphy said, in recent years, electronic devices and the rapid development of medical devices, is currently the biggest obstacle we face is that the implant will often induce specific immune responses, which the patient or the existence of certain risks; but these devices for patients benefit is its will slowly dissolve over time, the use of such sensors can also reduce the solubility surgeon surgical removal of the equipment required, which greatly reduces the risk of infection and complications of the patients body.

In the United States there are about 50,000 people each year die from trauma, such as traumatic brain injury, when a patient enters the hospital for treatment, the doctor must be conducted in patients with intracranial pressure measurement, because of the increased intracranial pressure often lead to further brain damage and the current through the brain scans and clinical characteristics, doctors can not reliably determine the patient's intracranial pressure. The researchers pointed out, but the most commonly used devices are based on 1980s technology developed, these devices larger, use more cumbersome, but also in the intensive care unit with its need to connect an external monitor to use. The new sensor developed by the researchers of this article, which is mainly composed of a polylactic acid polyglycolic acid (PLGA) and a silicone composition, but it can transmit accurate pressure, temperature, and other parameters. With the design and development of advanced materials and equipment, researchers might develop a more accurate implant electronically, and thereby facilitate the clinician operation.
Bolise Co., Ltd.

2016年1月25日星期一

NG108-15


Retinitis pigmentosa (RP) is a group of inherited disorders in which abnormalities of the photoreceptors (rods and cones) or the retinal pigment epithelium (RPE) of the retina lead to progressive visual loss. Stakeholders first experience defective dark adaptation or "night blindness," followed by a narrowing of the peripheral visual field and possibly a loss of central vision late in the course of the disease.

P3-X63-Ag8


Alzheimer's disease is associated with a dense accumulation of proteins in amyloid plaques in the brain containing fragments of amyloid-beta as the main component. If the development of amyloid plaques is responsible for neurodegeneration in Alzheimer's disease, a reduction in the formation of beta-amyloid and the progress of development may prevent the symptoms of the disease. Fragments of beta amyloid proteolytic processing of the amyloid precursor protein (APP) derivatives in neurons and the subsequent release of fragments in the extracellular space. APP is cleaved in the ER at residue 17 encoded by the activity of the alpha-secretase protease ADAM-10 and TACE. Beta-secretase activity, as recently identified BACE cleaves the N-terminus of beta-amyloid fragment. Gamma secretase cuts in the APP transmembrane domain at amino acids 40 and 42, the release of residues amyloid beta fragments 1-40 / 42 and short articles as ASP3 (residues 17-40 / 42), alpha secretase cleavage requires. The gamma-secretase activity requires the transmembrane protein presenilin-1, which is divided into an N-terminal fragment and C-terminal which are both required for the gamma-secretase activity. Mutations in presenilin-1 are genetically associated with familial forms of Alzheimer's disease, even supporting the role of APP processing to develop the disease. Inhibition of beta or gamma secretase can provide a mechanism to treat this disease. Other mechanisms altering the degradation of beta-amyloid and use of vaccines against amyloid beta aggregates to contain to remove.

Clear the "bad cholesterol"

Low-density lipoprotein cholesterol (LDL-C) is a form of cholesterol transport in the blood, commonly known as "bad cholesterol", the level of increase will increase the risk of coronary heart disease in the blood. Familial hypercholesterolemia (FH) an autosomal dominant genetic disease, whose patients from the early years began to appear in the blood will be abnormally high levels of LDL-C. Among them, the homozygous much more severe symptoms than heterozygotes: former plasma cholesterol levels 6-8 times higher than normal high; the latter plasma cholesterol concentration is 2 to 3 times normal. In addition, familial hypercholesterolemia atherosclerosis can also cause corneal bow and yellow tumors and other symptoms.

However, the launch of new drugs Amgen Repatha? (Generic name evolocumab) to the treatment of this disease has brought new solutions. ? Repatha is the world's first PCSK9 inhibitor class of lipid-lowering drugs (PCSK9: proprotein convertase subtilisin 9). PCSK9 in the human body can reduce the ability of the liver remove LDL-C in the blood, which in fact lead to elevated levels of the latter. Repatha? By binding to PCSK9, in order to prevent the latter to combine low-density lipoprotein cholesterol receptor (LDLR), thus inhibiting the LDLR degradation process mediated by the PCSK9, and promotes recycling of stem cells LDLR. Therefore, Repatha? Ultimately increase the number of liver cell surface used to clear the blood of "bad cholesterol" in the LDLR, played the role of lipid-lowering.

Repatha? Is a joint venture between Amgen and Anse Tektronix Japan established Amgen Astellas BioPharma KK R & D last year, has received FDA approval. And just last week, Repatha? Has finally been approved by the Japanese Ministry of Health, Labour and Welfare to market, for the treatment of familial hypercholesterolemia, as well as for HMG-CoA inhibitor drugs (statin, statin) is invalid and a high cardiovascular hypercholesterolemic patients the risk of disease. It became the first in Japan to be approved PCSK9 inhibitor class of lipid-lowering drugs.

Subvert the forefront of future military operations in biotechnology

Military Biotechnology is the application of modern biotechnology to a comprehensive cross-technology in the field of military technology, involving military, biology, physics, materials, information, and many other disciplines. Military biotechnology through numerous excellent reference and use of biological structure and special features, will achieve leapfrog innovation and development of weapons and equipment to provide a new source of weaponry has become an important driving force for change, and the continuous birth of a new form of combat and combat idea. In recent years, as the representative of the United States attaches great importance to the development of world military power military biotechnology, has made significant breakthroughs in many areas of biological materials, biomimetic and equipment, bio-computing, bio-fuels.

Biotechnology has become a new strategic high ground

Open historical picture is not difficult to find, change human warfare style of many major inventions were solidarity and biology of development and progress. For example, based on bird wings analysis, human design aircraft airfoil, and constantly promote the evolution of combat aircraft; by imitating the bat ultrasound, the invention of radar technology, the "telescope" is no longer a myth; reference dolphin ultrasonic detection, the invention of sonar technology, offer insight into the underwater world. Development of military biotechnology, will operate weapons, battlefield command, communications and logistics support qualitative change and leap, will become the commanding heights of military technology to provide new impetus to the development of conventional weaponry, including: military Biotechnology and Weaponry integration; military biotechnology will bring new weapons operating mode, weapons and equipment to promote "brain - machine combined with" direction; learn and use of biological numerous excellent structure and special features for weapons and equipment to achieve leapfrog innovation development of new sources; military biotechnology will improve battlefield awareness and information processing capabilities to provide new ways for the military logistical support.

Skirrow Agar Base


Product name:Skirrow Agar Base,Modified 
Packing(g/bottle):250

Application:
For the Isolation of Gonorrhoeae Campylobacter jejuni.

Formula: (g/L) 
peptone    15.0g
yeast powder    5.0g
Pancreatic casein peptone    2.5g
NaCL    5.0g
FeSO4    0.25g
Sodium metabisulphite     0.25g
sodium pyruvate    0.25g
agar    15.0g
PH     7.2-7.6

Piperonyl Methyl Ketone for sale

CAS:4676-39-5
Molecular Formula:C10H10O3
Molecular Weight:178.02g/mol
Description:It is used as pharmaceutical intermediates for the synthesis of antibiosis berberine, cardiovascular drugs methyl-L-dopa, anti-hypertensive and anti-tumor drugs, etc.
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HDMP-28

Product name:HDMP-28
Molecular Formula:C18H21NO2
Molecular Weight:283.365g/mol
Description:HDMP-28 or methylnaphthidate is a piperidine based stimulant drug. It is closely related to methylphenidate, but with the phenyl ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action and is a structural isomer of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate.
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