Although mutations always have a bad reputation, but a large number of mutations in perhaps not harmful; even in the very rare genetic disorder, only in the tens of thousands of genes in one or both mutations will actually caused diseases, and therefore distinguish harmful and beneficial mutation has been the focus of scientific research.
Scientists from Rockefeller University recently in Proceedings of the National Academy of the Sciences magazine published its latest research results, the article in which they developed a new tool designed to help predict whether a given human genes may contain promote disease mutation, the researchers hope the tool can help them a lot of genetic screening to help predict the occurrence of human diseases.
Yuval Itan researchers said, to get the first needle in a haystack also sucked seawater, while filtering out extraneous "noise" on key genes want to study clearly visible; by genomic analysis, the researchers found that 58 percent of rare mutations Located two percent of human genes, and they developed called Gene Damage Index (genetic damage index) tools can help infer, frequently mutated gene in the general population and perhaps less likely to lead to hereditary and the rarity of the disease , because these mutations in healthy individuals will frequently occur.
Such genetic damage index of tools that can help reveal a mutation occurs in the general population in the number of genes, or mutations accumulate damage, while the corresponding record the results may illustrate the importance of a particular gene on a given disease groups, such as cancer, Bangladesh Del's disease, autism and primary immune deficiency and the like. Finally, the researchers said, the use of this new tool you can weed out the 60% non-associated mutations, and genetic damage index tools will also help scientists to more easily obtain a large number of next-generation sequencing data analysis.
2015年12月30日星期三
2015年12月29日星期二
L-Ornithine L-Aspartate
BACKGROUND / AIMS: In the current knowledge of the pathophysiology of hepatic encephalopathy, a reduction of hyperammonemia is the most important evidence for effective treatment. Therefore, the therapeutic efficacy of oral L-ornithine L-aspartate, ammonia detoxification with improved faculties studied in patients with cirrhosis, hyperammonemia and stable, open chronic hepatic encephalopathy and subclinical hepatic encephalopathy in a randomized , double-blind, placebo-controlled clinical trial.
Methods: Oral L-ornithine L-aspartate was administered three times daily at fixed times for 14 consecutive days in a total dose of 18 g per day. The design has been chosen to increase the ammonia can be induced by a protein powder, 0.25 g / kg body weight administered daily to prevent the start of the treatment period. Efficacy variables were: fasting and postprandial ammonia concentration, number connection test time, mental state and qualities of an index of portosystemic encephalopathy. The analyzes were performed on the total population of the study and placebo 32 34 L-ornithine L-aspartate treated patients and the sub-groups of samples in the open air (20 placebo and 23 L-ornithine L-aspartate treaties) on the base and subclinical hepatic encephalopathy (12 placebo and 11 L-ornithine L-aspartate) treated patients.
Results: connection test performance time at (p <0.01) and fasting (p <0.01) and postprandial (p <0.05) showed venous blood ammonia concentrations in the group L-aspartate-L-ornithine treated an improvement relative to placebo. In addition, the mental state level (p <0.05) and the index of portosystemic encephalopathy (p <0.01) significantly improved in group L-aspartate L-ornithine as in the placebo group. Side effects have been observed in placebo patients or L-aspartate-treated L-ornithine.
Calcium-alpha-ketoglutarate
Product name:Calcium-alpha-ketoglutarate
CAS:51828-96-7
Molecular formula:C5H4CaO5•H2O
Molecular weight:327
Product description: Calcium-alpha-ketoglutarate is a mineral calcium in a special form to help normalize concentrations of ordinary calcium in the body. Calcium-alpha-ketoglutarate eliminates excess phosphate in the blood by binding to it and passed into waste. This helps re-establish the balance between calcium and phosphate in your body.
from:http://www.chemicalspharm.com/products/Pharmaceutical-Intermediates/5271/
Sipeimine price
Product name: Sipeimine
CAS: 61825-98-7
Appearance: White Crystal Powder
Application: All our products are for research and lab only. Injecting, eating and other ways are forbidden.
Purity: ≥98%
Molecular Formula: C27H43NO3
Molecular Weight: 429.62
Description: Easily soluble in chloroform, ethyl acetate, soluble in methanol, alcohol, acetone, diethyl ether, insoluble in water and petroleum ether. Spasmolysis.
from:http://www.chemicalspharm.com/products/Pharmaceutical-Intermediates/Sipeimine/
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Akebia saponin D for sale
CAS: 39524-08-8
Appearance: Needle crystal powder
Application: All our products are for research and lab only. Injecting, eating and other ways are forbidden.
Purity: >95% or 98% by HPLC
Molecular Formula: C47H76O18
Molecular Weight: 929.10
Description: 1g soluble in 87ml water, 3ml boiling water, 6ml alcohol, 100ml diethyl ether, 10ml glycerinum and 5ml acetone. Mostly insoluble in benzene, chloroform and petroleum ether. Hemostasis, promote healing of bone lesions, lower uterine contractions, nourishing liver and kiney.
from:http://www.chemicalspharm.com/products/Pharmaceutical-Intermediates/Akebia-saponin-D/
New discoveries or help develop a malaria vaccine
Scientists from the University of Oxford, etc., perhaps to find a new way to target the malaria parasite; now the impact of malaria each year with more than 40 million lives, and most patients are Plasmodium falciparum (Plasmodium falciparum) caused by infection, but life In the area of malaria outbreaks often people will get a special natural state of immunity to help the body resist malaria infection in adulthood, so the discovery of the possibility of a vaccine against malaria means is from the molecular level up to reveal the body's natural immune these special groups reaction process.
When P. falciparum infection and the body hidden in the red blood cells will lead to serious cause of malaria deaths occur, after many studies have shown that the main component of the body's protective immune response against the surface antigen can be directly called variant , while Plasmodium can use this particular antigen inserted into the surface of the infected red blood cells, usually falciparum will use these molecules to control the infected cell so that it can be adhered to the inner wall of the blood vessel supply of organs, if a large number of Plasmodium infection RBC accumulation will lead to the occurrence of cerebral malaria in the brain.
Under normal circumstances falciparum can produce a variety of different variations of manufacturing surface antigen family, the process although these antigenic molecules naturally acquired immunity in malaria incidence and serious plays an important role, and it usually is because it has diversity I do not think the appropriate candidate vaccines; however Looking for specific antibodies to react with the surface antigen of Plasmodium falciparum variant seems to be able to help develop new interventions against malaria.
The researchers noted that this variant surface antigens include PfEMP1, RIFINs and STEVOR molecules, the researchers had focused on the PfEMP1 molecule research studies, but this study they found two individuals carrying the antibody does not recognize PfEMP1, but will RIFINs molecular recognition; at the molecular level, reactive antibodies can be produced by the body's natural process of independent new event to trigger, and migration and insertion of DNA will come through this process occurs in the gene, called LAIR1 of.
When P. falciparum infection and the body hidden in the red blood cells will lead to serious cause of malaria deaths occur, after many studies have shown that the main component of the body's protective immune response against the surface antigen can be directly called variant , while Plasmodium can use this particular antigen inserted into the surface of the infected red blood cells, usually falciparum will use these molecules to control the infected cell so that it can be adhered to the inner wall of the blood vessel supply of organs, if a large number of Plasmodium infection RBC accumulation will lead to the occurrence of cerebral malaria in the brain.
Under normal circumstances falciparum can produce a variety of different variations of manufacturing surface antigen family, the process although these antigenic molecules naturally acquired immunity in malaria incidence and serious plays an important role, and it usually is because it has diversity I do not think the appropriate candidate vaccines; however Looking for specific antibodies to react with the surface antigen of Plasmodium falciparum variant seems to be able to help develop new interventions against malaria.
The researchers noted that this variant surface antigens include PfEMP1, RIFINs and STEVOR molecules, the researchers had focused on the PfEMP1 molecule research studies, but this study they found two individuals carrying the antibody does not recognize PfEMP1, but will RIFINs molecular recognition; at the molecular level, reactive antibodies can be produced by the body's natural process of independent new event to trigger, and migration and insertion of DNA will come through this process occurs in the gene, called LAIR1 of.
Gene mutation screening tool available, will reveal the mystery of genetic disease!
Guided by public opinion, for gene mutation, people always talk about the discoloration. In fact, the vast majority of human genetic mutations are harmless, even in the hereditary disease, which is also due to pathogenic mutations showed only 1-2 genes only. Therefore, how to carry out targeted etiology research, how to distinguish between harmful and harmless gene mutation, it has been a serious challenge facing scientists.
Recently, scientists from Rockefeller University, St. Giles human infectious diseases Genetics Laboratory invented a new type of genetic screening tool Gene Damage Index, used to predict the likelihood of certain human genes causative mutations, to aid researchers screening and pathogenic mutations due to independent information from a large number of genes. Without this aid, the difficulty of screening comparable needle in a haystack, and the results are likely to deviate from the scientific truth. At present, the details of the screening tool has been published in "PNAS" (Proceedings of the National Academy of Sciences) magazine.
Gene Damage Index mainly on a gene mutation rate in the human gene pool, or the "cumulative mutations damage", but also by calculating a gene in a specific disease areas, such as Mendelian diseases, cancer, autism and primary Immunodeficiency Disease contribution to measure its pathogenic significance.
Through genomic analysis, researchers have found that 58% of rare genetic variation is only 2% of human genes detected. St. Giles Laboratory research team used this tool to detect some of the high mutation rate of the gene in healthy volunteers and in patients with genetic, whereby they infer these high mutation rate is not a genetic disease or a rare genetic disease etiology true.
Yuval Itan author of the study, said the use of Gene Damage Index screening tool, we will be able to effectively eliminate 60% of non-correlation between genetic variation and help the next generation of researchers from the vast gene sequences more quickly and effectively identify genes associated with genetic diseases mutation.
Recently, scientists from Rockefeller University, St. Giles human infectious diseases Genetics Laboratory invented a new type of genetic screening tool Gene Damage Index, used to predict the likelihood of certain human genes causative mutations, to aid researchers screening and pathogenic mutations due to independent information from a large number of genes. Without this aid, the difficulty of screening comparable needle in a haystack, and the results are likely to deviate from the scientific truth. At present, the details of the screening tool has been published in "PNAS" (Proceedings of the National Academy of Sciences) magazine.
Gene Damage Index mainly on a gene mutation rate in the human gene pool, or the "cumulative mutations damage", but also by calculating a gene in a specific disease areas, such as Mendelian diseases, cancer, autism and primary Immunodeficiency Disease contribution to measure its pathogenic significance.
Through genomic analysis, researchers have found that 58% of rare genetic variation is only 2% of human genes detected. St. Giles Laboratory research team used this tool to detect some of the high mutation rate of the gene in healthy volunteers and in patients with genetic, whereby they infer these high mutation rate is not a genetic disease or a rare genetic disease etiology true.
Yuval Itan author of the study, said the use of Gene Damage Index screening tool, we will be able to effectively eliminate 60% of non-correlation between genetic variation and help the next generation of researchers from the vast gene sequences more quickly and effectively identify genes associated with genetic diseases mutation.
Enhance memory study found that a protein
Increase brain levels of a specific DNA recombinase can significantly improve their cognitive abilities. This finding is subject neuroscience research center headed by Prof. Hilmar Bading of Heidelberg University Cross. Mice show, Dnmt3a2 protein can improve memory. Because this protein will affect the fear of memory and the ability to remove such bad memories, researchers hope these findings can be used to develop new treatments for traumatic neurosis and other forms of anxiety. The results of this study are published in the "Molecular Psychiatry" magazine.
In an earlier study, the scientists found that low levels of Dnmt3a2 protein in the brain of aging mice. When older animals were injected with the virus produces this protein, that will increase their ability to remember. "We have now found that increasing Dnmt3a2 level in the brain of young mice can improve their cognitive abilities." Bading professor explained. In many different long-term memory tests, including typical Pavlovian conditioning experiment, the scientists were able to prove that there is more Dnmt3a2 mice behaved better.
Dnmt3a2 is an epigenetic regulator, it can be chemically modify the genetic material DNA. The result is the production of a specific protein changes in velocity. Activation of gene transcription of genetic information can be transferred to RNA, followed by the synthesis of new proteins, play an important role in memory consolidation and disappearing. Heidelberg neuroscientists and therefore in a patient using allopathic methods are similar to "eliminate" the experiment. This therapy for the treatment of traumatic neurosis, aimed interrupt or even completely eliminate disturbing relevance. We found that the brain contains a high level of Dnmt3a2 mice can eliminate the pain associated with a particular region and stimulate greater role between. "Bading explained.
In an earlier study, the scientists found that low levels of Dnmt3a2 protein in the brain of aging mice. When older animals were injected with the virus produces this protein, that will increase their ability to remember. "We have now found that increasing Dnmt3a2 level in the brain of young mice can improve their cognitive abilities." Bading professor explained. In many different long-term memory tests, including typical Pavlovian conditioning experiment, the scientists were able to prove that there is more Dnmt3a2 mice behaved better.
Dnmt3a2 is an epigenetic regulator, it can be chemically modify the genetic material DNA. The result is the production of a specific protein changes in velocity. Activation of gene transcription of genetic information can be transferred to RNA, followed by the synthesis of new proteins, play an important role in memory consolidation and disappearing. Heidelberg neuroscientists and therefore in a patient using allopathic methods are similar to "eliminate" the experiment. This therapy for the treatment of traumatic neurosis, aimed interrupt or even completely eliminate disturbing relevance. We found that the brain contains a high level of Dnmt3a2 mice can eliminate the pain associated with a particular region and stimulate greater role between. "Bading explained.
How to buy Hexaplant Richter
Product name:Hexaplant Richter
Description:
Hexaplant Richter is especially designed for the care of dull hair and stressed scalp.Also suitable for skin care.The product contains extracts from the herbs fennel,hops,camomile,balm mint,mistletoe and yarrow.
Hexaplant Richter is especially designed for the care of dull hair and stressed scalp.Also suitable for skin care.The product contains extracts from the herbs fennel,hops,camomile,balm mint,mistletoe and yarrow.
For more, please click:sales@chemicalspharm.com
Non-invasive early cancer diagnosis within one hour report on the results system
AWSensors company with the European plan LIQBIOPSENS team developed a new type of liquid biopsy technique used for early diagnosis of colorectal cancer, the system can help quickly and easily conduct cancer diagnosis, and monitoring of cancer, compared to current diagnostic technology in terms of saving two-thirds of the costs.
In Spain AWSensors developed this highly sensitive molecular diagnostic system can be used to screen for cancer, which is based on liquid biopsy technique that resembles a small liquid sample of blood or saliva for analysis, enabling to complete the non-invasive diagnosis of cancer, and the technology can give the test results within an hour, when combined with the analysis of its genome is likely to obtain reliable diagnostic results, and provide help for the later development of accurate cancer chemotherapy .
This new diagnostic system will work with the Polytechnic University of Valencia developed quartz micro-sensor technology, the quartz micro-sensor technology can provide real-time analysis, a combination that can be reliably performed after DNA mutation. The new inspection system common in the next three years will be used to colorectal cancer patients blood samples for testing, and the current of colorectal cancer is the second leading cause of cancer deaths in Europe, but also, and breast, lung and prostate cancer in parallel cancer.
The current preferred method of reliable diagnosis of cancer is tumor tissue biopsy, but this method is invasive, but also very painful for the patient and expensive, and the technology is only a single aspect of the disease progression can provide information to patients; and article In this new system development, or at least three times cheaper than the cost of the current real-time monitoring methods, such as real-time quantitative PCR technology. The researchers plan to carry out this LiqBiopSens aims to develop simple, inexpensive and without early diagnosis and monitoring of invasive cancer.
By detecting mutations associated with cancer tumor tissue to release the body of DNA, the new technique can reliably existence and evolution of cancer diagnosis and avoid false positive results. Currently AWSensors has begun trying to make use of the crystal sensor so that it can work efficiently, and better detect molecular differences between different liquids biopsies and materials.
In Spain AWSensors developed this highly sensitive molecular diagnostic system can be used to screen for cancer, which is based on liquid biopsy technique that resembles a small liquid sample of blood or saliva for analysis, enabling to complete the non-invasive diagnosis of cancer, and the technology can give the test results within an hour, when combined with the analysis of its genome is likely to obtain reliable diagnostic results, and provide help for the later development of accurate cancer chemotherapy .
This new diagnostic system will work with the Polytechnic University of Valencia developed quartz micro-sensor technology, the quartz micro-sensor technology can provide real-time analysis, a combination that can be reliably performed after DNA mutation. The new inspection system common in the next three years will be used to colorectal cancer patients blood samples for testing, and the current of colorectal cancer is the second leading cause of cancer deaths in Europe, but also, and breast, lung and prostate cancer in parallel cancer.
The current preferred method of reliable diagnosis of cancer is tumor tissue biopsy, but this method is invasive, but also very painful for the patient and expensive, and the technology is only a single aspect of the disease progression can provide information to patients; and article In this new system development, or at least three times cheaper than the cost of the current real-time monitoring methods, such as real-time quantitative PCR technology. The researchers plan to carry out this LiqBiopSens aims to develop simple, inexpensive and without early diagnosis and monitoring of invasive cancer.
By detecting mutations associated with cancer tumor tissue to release the body of DNA, the new technique can reliably existence and evolution of cancer diagnosis and avoid false positive results. Currently AWSensors has begun trying to make use of the crystal sensor so that it can work efficiently, and better detect molecular differences between different liquids biopsies and materials.
2015年12月27日星期日
best Benzo Fury,and for sale
Description:6-(2-aminopropyl)benzofuran or 1-benzofuran-6-ylpropan-2-amine (6-APB) is thought to be a stimulant and entactogen drug although to date, no authoritative source can say even whether or not it is psychoactive. Chemically, it is of the phenethylamine and amphetamine classes.
From:http://www.chemicalspharm.com/New-Products/Benzo-Fury-/
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Beta-Methoxy Phenylethylamine for sale
Beta-Methoxy- Phenylethylamine is the newest compound on the dieting circuit that is offering the most promising results.Beta-Methoxy Phenylethlyamine, which is also called Beta-Methoxy PEA, is a new ingredient that is exclusive to Dren. Beta-Methoxy PEA is able to increase the noradrenaline release from the sympathetic nerve terminals. Beta-Methoxy PEA is able to stimulate the sympathetic nervous system. This is done by causing the pre-synaptic nerve terminals to release norepinephrine into the synaptic space.
From:http://www.chemicalspharm.com/New-Products/Beta-Methoxy-Phenylethylamine-/
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2015年12月24日星期四
Sodium dicyanamide for sale
Product name:Sodium dicyanamide
CAS:1934-75-4
Molecular Formula:C2N3Na
Molecular Weight:89.03g/mol
Description:Sodium dicyanamide is used or the production of pharmaceuticals (chlorhexidine, biguanide, proguanil and alexidine).
Injection strong antibody inhibits HIV virus in the blood
NIH scientists from the United States in the international academic journals published a new study progress, they reported that injection called VRC01 potent antibodies can be suppressed not receiving antiretroviral therapy for HIV in the blood of HIV carriers Level. The researchers also found that by intravenous or subcutaneous injection manner VRC01 HIV antibody in vivo has a very good safety and tolerability and injection antibody can be maintained for a long time in the patient's blood.
Scientists led Phase I clinical trials including a total of 23 HIV carriers, of which 15 were receiving antiretroviral therapy, eight others received no treatment. Researchers treated with HIV antibodies were injected twice, but did not receive antiretroviral therapy carriers only accept the first antibody injection, researchers then antibody injection safety and can reduce plasma and blood cells viral load were assessed.
The researchers found that although the antibody injection did not reduce the amount of HIV in blood cells, but did not receive antiretroviral therapy 6 out of 8 in plasma viral load dropped by more than 10-fold decrease in viral load in patients They started the study when the least amount of carrying the virus, and after antibody injection, HIV virus to maintain effective antibody concentration in nearly three weeks was suppressed at an extremely low level, a significant decline in viral load rest of 4 people, but It did not fall to undetectable levels. And after receiving antibody treatment detected but no change in viral load in the body of the other two types can carry the HIV virus resistant to VRC01 antibody production. Patients who have received anti-retroviral therapy in vivo inhibition of HIV has been accepted antibody injection did not show any other effect.
Scientists led Phase I clinical trials including a total of 23 HIV carriers, of which 15 were receiving antiretroviral therapy, eight others received no treatment. Researchers treated with HIV antibodies were injected twice, but did not receive antiretroviral therapy carriers only accept the first antibody injection, researchers then antibody injection safety and can reduce plasma and blood cells viral load were assessed.
The researchers found that although the antibody injection did not reduce the amount of HIV in blood cells, but did not receive antiretroviral therapy 6 out of 8 in plasma viral load dropped by more than 10-fold decrease in viral load in patients They started the study when the least amount of carrying the virus, and after antibody injection, HIV virus to maintain effective antibody concentration in nearly three weeks was suppressed at an extremely low level, a significant decline in viral load rest of 4 people, but It did not fall to undetectable levels. And after receiving antibody treatment detected but no change in viral load in the body of the other two types can carry the HIV virus resistant to VRC01 antibody production. Patients who have received anti-retroviral therapy in vivo inhibition of HIV has been accepted antibody injection did not show any other effect.
Sodium Dehydrocholate
Product name:Sodium Dehydrocholate
CAS:145-41-5
Molecular Formula:C24H33NaO5
Molecular Weight:424.51g/mol
Description:Sodium dehydrocholate was applied topically to the right hemispheric cortex of eight rats and the electrocorticogram was monitored from both the treated cortex and the homotopic cortex of the contralateral hemisphere. All animals developed blood-brain barrier (BBB) disruption in the treated cortex as evidenced by cortical staining with systemically administered Evans blue dye. Spike activity developed in three of eight animals after the topical application of dehydrocholate.
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2015年12月23日星期三
Carbon Tetrachloride of pharmaceutical products
Product name:Carbon Tetrachloride
CAS: 56-23-5
Molecular Formula:CCl4
Formula Weight:153.82
Description:
Carbon tetrachloride, also known by many other names (notably, carbon tet in the cleaning industry, and as a Halon or Freon in HVAC, see Table for others) is the organic compound with the formula CCl4. It was formerly widely used in fire extinguishers, as a precursor to refrigerants, and as a cleaning agent. It is a colourless liquid with a "sweet" smell that can be detected at low levels.
Both carbon tetrachloride and tetrachloromethane are acceptable names under IUPAC nomenclature. Colloquially, it may be called "carbon tet".
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Bifidobacterium longum
Product name:Bifidobacterium longum
Description:Bifidobacterium longum is one of most important inhabitants in the human body. This bacterium is very helpful because it maintains a normal digestive tract, inhibits the growth of harmful bacteria, and also boosts the immune system.
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Magnesium Pidolate
Molecular Weight:280.52g/mol
Description:Magnesium pidolate, the magnesium salt of pidolic acid (pyroglutamic acid), is a mineral supplement.It is white crystalline or granular powder. Freely soluble in water. Slightly soluble in alcohol.
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Caprylyl Glycol of pharmaceutical products
Product name:Caprylyl Glycol
CAS:1117-86-8
Molecular Formula:C8H18O2
Molecular Weight:146.23g/mol
Description:Caprylyl glycol is a linear diol. It is typically used as a hair and skin conditioning agent, an emollient and a humectant in personal care products, although it may also contribute to preservation of cosmetic products due to its anti-bacterial properties.
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What is Avanafil ?
Product name:Avanafil
CAS:330784-47-9
Molecular Formula:C23H26ClN7O3
Formula Weight:483.95g/mol
Description:It acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are sildenafil, tadalafil and vardenafil.
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PLoS Medicine: Targeting α therapy can effectively help eliminate the ability of HIV-infected cells
Α targeted therapies possible to selectively eliminate HIV-infected cells in the central nervous system. Studies have shown that specific human antibody labeled with α emitter bismuth --213 can penetrate the blood-brain barrier and selectively target and destroy HIV-infected cells while preserving healthy cells uninfected. These findings may open up a new option for the treatment of HIV-associated neurocognitive disorders.
In vitro studies with scientific articles as the foundation, under the direction of various research institutions, including the New York Einstein College of Medicine and the Joint Research Centre. It shows the new α emitter radiopharmaceutical without damage to simulate human blood-brain barrier can penetrate it, and then selectively bind and kill located nervous system in HIV-infected cells. Especially in human tissue its high energy and short path length, which is based on the unique physical characteristics of α radiation selectively kill diseased cells while preserving surrounding healthy tissue.
Antiretroviral combination therapy (cART) for HIV-positive patients can survive longer. But the body of the virus reservoir sac still exist and continue to cause damage. In particular the treatment of central nervous system infection is more difficult, because the blood-brain barrier limited the treatment of a number of anti-viral drugs in combination therapy. Currently, about half of HIV-infected patients with mild to moderate neurological disorders.
The study was supported by the Bill and Melinda Gates Foundation and the National Institutes of Health. Einstein College of Medicine and the Joint Research Centre has been working for a decade, aimed at the joint development of common bacterial, fungal and viral infections, targeting α therapies including HIV.
In vitro studies with scientific articles as the foundation, under the direction of various research institutions, including the New York Einstein College of Medicine and the Joint Research Centre. It shows the new α emitter radiopharmaceutical without damage to simulate human blood-brain barrier can penetrate it, and then selectively bind and kill located nervous system in HIV-infected cells. Especially in human tissue its high energy and short path length, which is based on the unique physical characteristics of α radiation selectively kill diseased cells while preserving surrounding healthy tissue.
Antiretroviral combination therapy (cART) for HIV-positive patients can survive longer. But the body of the virus reservoir sac still exist and continue to cause damage. In particular the treatment of central nervous system infection is more difficult, because the blood-brain barrier limited the treatment of a number of anti-viral drugs in combination therapy. Currently, about half of HIV-infected patients with mild to moderate neurological disorders.
The study was supported by the Bill and Melinda Gates Foundation and the National Institutes of Health. Einstein College of Medicine and the Joint Research Centre has been working for a decade, aimed at the joint development of common bacterial, fungal and viral infections, targeting α therapies including HIV.
Create emotional resonance to promote world peace!
do you know? Emotional resonance can also be learned. A new study conducted by researchers at the University of Zurich found pleasure experience with others can trigger learning effects between the brain and increase the emotional resonance.
There is a conflict between people from different countries and cultural backgrounds are often due to "outsiders" lack emotional resonance and mercy, thus increasing the emotional resonance that can help people live together in peace. Psychologists and neurobiologists emotional resonance for the University of Zurich studied whether and how positive energy affect the human brain and the formation of emotional resonance response process were determined.
Strangers suffer pain inhibits emotional resonance related brain responses, the researchers will take this as a lack of emotional resonance model, examined whether and how to promote learning interventions outside the group of strangers to emotional resonance. In the course of this intervention, participants can accept one other group members within an economy or their own members of the group to help relieve pain stimuli. Researchers brain activation of participants were recorded.
In the beginning of the study, participants brain strangers pain response situation is weak, and the members of their own group within the reaction is stronger. But when the group helped give participants a member of pain occurs outside the brain participants will have a very significant response enhancement, and the more members of the group outside pleasure experience, this will be more emotional resonance increase significantly.
The researchers said that the formation of a pleasant experience with a stranger leads to the formation of neural learning signal, and will further enhance the group of strangers outside the brain response to pain, empathize, this pleasant experience but also further promote the formation of groups of strangers emotional resonance of other members.( Bolise Co., Ltd. http://www.chemicalspharm.com/ )
There is a conflict between people from different countries and cultural backgrounds are often due to "outsiders" lack emotional resonance and mercy, thus increasing the emotional resonance that can help people live together in peace. Psychologists and neurobiologists emotional resonance for the University of Zurich studied whether and how positive energy affect the human brain and the formation of emotional resonance response process were determined.
Strangers suffer pain inhibits emotional resonance related brain responses, the researchers will take this as a lack of emotional resonance model, examined whether and how to promote learning interventions outside the group of strangers to emotional resonance. In the course of this intervention, participants can accept one other group members within an economy or their own members of the group to help relieve pain stimuli. Researchers brain activation of participants were recorded.
In the beginning of the study, participants brain strangers pain response situation is weak, and the members of their own group within the reaction is stronger. But when the group helped give participants a member of pain occurs outside the brain participants will have a very significant response enhancement, and the more members of the group outside pleasure experience, this will be more emotional resonance increase significantly.
The researchers said that the formation of a pleasant experience with a stranger leads to the formation of neural learning signal, and will further enhance the group of strangers outside the brain response to pain, empathize, this pleasant experience but also further promote the formation of groups of strangers emotional resonance of other members.( Bolise Co., Ltd. http://www.chemicalspharm.com/ )
NSMB: Apparent family added a new member of genetically modified
Researchers from Cambridge University have discovered a new epigenetic modification, further expanding the epigenetic modification of "team." The study, published in the international academic journal Nature Structural and Molecular Biology of the latest research shows that the presence of humans, mice and other vertebrates species DNA modification more than we thought possible.
Epigenetics environmental and behavioral (such as diet and smoking habits) affect DNA, and this affects how inherited to the next generation or the next generation provides a possible explanation. Epigenetic current research mainly focused on histone modifications, epigenetic histone modifications in addition to gene may also occur through modification of DNA bases are directly regulated, and is currently found mainly in the cytosine DNA modification .
In this study, the researchers found that the gene human, mouse and other species in the methylation of adenine, but the number is far less than adenine methylation of cytosine methylation, whole genome Such modifications are only about 1700 will happen adenine, adenine methylation distributed throughout the genome, but does not appear on exon.
The authors said: "These new modified found in abundance in the genome is very low, but that does not mean they are not important we do not know their specific role, but the new modifications are likely to DNA, genes. Regulation even have a major impact on human health. "
The researchers found a new DNA modification in this study RNA modification process. They use a specific RNA modified antibodies identified to find out whether there is a similar modification on DNA, and found that the existence of this situation on the DNA. The researchers further proved by this appear in the DNA of the new modification is not false-positive results occur by RNA contamination.
( Bolise Co., Ltd. http://www.chemicalspharm.com/ )
Epigenetics environmental and behavioral (such as diet and smoking habits) affect DNA, and this affects how inherited to the next generation or the next generation provides a possible explanation. Epigenetic current research mainly focused on histone modifications, epigenetic histone modifications in addition to gene may also occur through modification of DNA bases are directly regulated, and is currently found mainly in the cytosine DNA modification .
In this study, the researchers found that the gene human, mouse and other species in the methylation of adenine, but the number is far less than adenine methylation of cytosine methylation, whole genome Such modifications are only about 1700 will happen adenine, adenine methylation distributed throughout the genome, but does not appear on exon.
The authors said: "These new modified found in abundance in the genome is very low, but that does not mean they are not important we do not know their specific role, but the new modifications are likely to DNA, genes. Regulation even have a major impact on human health. "
The researchers found a new DNA modification in this study RNA modification process. They use a specific RNA modified antibodies identified to find out whether there is a similar modification on DNA, and found that the existence of this situation on the DNA. The researchers further proved by this appear in the DNA of the new modification is not false-positive results occur by RNA contamination.
( Bolise Co., Ltd. http://www.chemicalspharm.com/ )
Hydroxylimine Hcl is what pharmaceutical products
Product name:hydroxylimine Hcl
CAS:90717-16-1
Molecular Formula:C13H16ClNO.ClH
Molecular Weight:274.19g/mol
Description:It is a brown and cream powder.Hydroxylimine Hydrochloride is used for the pharmaceutical intermediate.
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sales@chemicalspharm.com
2015年12月22日星期二
Perenol E8 describes the role and composition
Product name:Perenol E8
Composition:Silicone
Volume of Addition:0.3-1.0, the finished paint
Product Description:Perenol E8 is a degassing additives, especially it is used as an air-release agent also for systems that are applied in thick are coatings for flooring, casting and molding based on 2-pack epoxies, unsaturated polyester and PUR provides films and surrfaces without any foam or bubbles after curing even at film thicknesses of more than 1 does not affect the defoaming effect at low temperature conditions.
from:http://www.chemicalspharm.com/New-Products/Perenol-E8-/
Pfizer's antidepressant Pristiq failed in adolescents
Pfizer today reported its antidepressant Pristiq (desvenlafaxine succinate extended release) in adolescents (7-17 years) with severe depression fail in clinical trials groups, and no significant improvement compared to placebo. This test a total of 363 patient involvement, of which 30 per cent of children aged 7-11. Test consists of three arms, namely the placebo, low dose (equivalent to an adult body weight equivalent to 25 mg daily) and high dose (equivalent to an adult body weight equivalent to 35 mg per day), there was no statistical difference between the results of the efficacy of the three groups.
Pristiq is original Wyeth products, Wyeth was acquired after 2009 became a member of the Pfizer Pfizer product lines. This product has been listed in 2008, but then there are some strings attached. One of the conditions is that Wyeth must follow the requirements of the Equality Act Youth Research do teenagers efficacy in clinical trials. In June this year, another adolescent patients in clinical trials of Pristiq also failed to improve symptoms better than placebo.
Venlafaxine is the first serotonin - norepinephrine reuptake inhibitors, and Prozac but regardless of the molecular structure or mechanism are very similar. Venlafaxine is one of Wyeth's flagship product, so the patent expired in 2010 have developed a new generation product Wyeth Pristiq. Pristiq is the active metabolite of venlafaxine (at least one Class A), so theoretically venlafaxine similar effect. A selling point is the Pristiq than venlafaxine easy to use, because the latter have to have a dose-climbing process. But Pristiq even in clinical trials in adults also general effect, more improvement than placebo only 2-3 points Hamilton index, and high-dose (100 mg) effect disappears. This dose-response relationship, although not impossible, but how much reliability doubtful efficacy.
In view of the above information Pristiq invalid in adolescent patients is not too unexpected. Adolescents and adults are quite different brain, liver and kidney metabolism is also more active, and there are some unknown factors now make many very reliable efficacy in adult drugs among adolescents is invalid. One theory is that these drugs are used to optimize adult animal model, so the success rate is higher than in adult children. But even these animal models of disease for adults is also very unreliable, I highly doubt with minor animal model can significantly improve the success rate of depression in adolescents drugs. A surprising data is that this experiment, 30% of patients are children 7-11 years of age. Age is so small it is unfortunately suffering from severe depression.
CNS field to extend the product with the active metabolite of life is quite common, because there is no reliable way to optimize. Although there is no venlafaxine Pristiq brilliant sales but also a sort of a small product. Today, the results of this test basically blocked the youth market Pristiq entering this road.
( Bolise Co., Ltd. http://www.chemicalspharm.com/ )
Pristiq is original Wyeth products, Wyeth was acquired after 2009 became a member of the Pfizer Pfizer product lines. This product has been listed in 2008, but then there are some strings attached. One of the conditions is that Wyeth must follow the requirements of the Equality Act Youth Research do teenagers efficacy in clinical trials. In June this year, another adolescent patients in clinical trials of Pristiq also failed to improve symptoms better than placebo.
Venlafaxine is the first serotonin - norepinephrine reuptake inhibitors, and Prozac but regardless of the molecular structure or mechanism are very similar. Venlafaxine is one of Wyeth's flagship product, so the patent expired in 2010 have developed a new generation product Wyeth Pristiq. Pristiq is the active metabolite of venlafaxine (at least one Class A), so theoretically venlafaxine similar effect. A selling point is the Pristiq than venlafaxine easy to use, because the latter have to have a dose-climbing process. But Pristiq even in clinical trials in adults also general effect, more improvement than placebo only 2-3 points Hamilton index, and high-dose (100 mg) effect disappears. This dose-response relationship, although not impossible, but how much reliability doubtful efficacy.
In view of the above information Pristiq invalid in adolescent patients is not too unexpected. Adolescents and adults are quite different brain, liver and kidney metabolism is also more active, and there are some unknown factors now make many very reliable efficacy in adult drugs among adolescents is invalid. One theory is that these drugs are used to optimize adult animal model, so the success rate is higher than in adult children. But even these animal models of disease for adults is also very unreliable, I highly doubt with minor animal model can significantly improve the success rate of depression in adolescents drugs. A surprising data is that this experiment, 30% of patients are children 7-11 years of age. Age is so small it is unfortunately suffering from severe depression.
CNS field to extend the product with the active metabolite of life is quite common, because there is no reliable way to optimize. Although there is no venlafaxine Pristiq brilliant sales but also a sort of a small product. Today, the results of this test basically blocked the youth market Pristiq entering this road.
( Bolise Co., Ltd. http://www.chemicalspharm.com/ )
4-AcO-MiPT describes the role and composition
Product name:4-AcO-MiPT
CAS:92292-84-7
Molecular Formula:C14H18N2O2
Molecular Weight:246.3g/mol
Description:The purity of this product is 99.8%.It is white powder and crystal.
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Elocalcitol describes the role and composition
Product name:Elocalcitol
CAS:199798-84-0
Molecular Formula:C29H43FO2
Formula Weight:442.65g/mol
Description:Elocalcitol is a vitamin D receptor agonist inhibiting Rho kinase signaling in rat and human bladder.It is an analogue of calcitriol that possesses the desirable properties of calcitriol but does not cause hypercalcemia.
Would like to ask specific details, please click here Email:sales@chemicalspharm.com
Cure for Alzheimer's disease! Clinton appealed to invest $ 2 billion
On Tuesday, Democratic presidential candidate Hillary • Clinton announced a program to promote Alzheimer's treatment plan, and seek to completely cure the disease by 2025, including specific measures to increase the disease and its related disorders research grants and so on.
According to Reuters, Clinton called for the establishment of a $ 2 billion per year and ten-year study of long-term investment plan, she said in a statement, said the government should help those afflicted by the disease of millions of families, increased investment in research to effective prevention and treatment of this disease, and to seek to achieve by 2025 a long-term goal of a complete cure of the disease.
Alzheimer's disease is an irreversible, progressive brain disease, is the most common type of dementia, accounting for 60-80% of all dementia cases. Alzheimer's disease will continue to be the most important public health challenges facing the United States, an estimated 5 million Americans over age 65 suffer from Alzheimer's disease, which is the US National Institute of Aging (National Institute on Aging) the sixth leading cause of death mentioned.
In the United States each year with Alzheimer's disease is directly related expenditures reached $ 203 billion, if the impact of the disease progression, delay disability-related aspects of dementia do not make a difference, by 2050, this figure is expected to increase to 10,000 One hundred million U.S. dollars. Hillary Clinton's campaign team noted that aggressive treatment of this disease is an effective way to help the government reduce the health insurance plans and health insurance burden.
According to Reuters, Clinton called for the establishment of a $ 2 billion per year and ten-year study of long-term investment plan, she said in a statement, said the government should help those afflicted by the disease of millions of families, increased investment in research to effective prevention and treatment of this disease, and to seek to achieve by 2025 a long-term goal of a complete cure of the disease.
Alzheimer's disease is an irreversible, progressive brain disease, is the most common type of dementia, accounting for 60-80% of all dementia cases. Alzheimer's disease will continue to be the most important public health challenges facing the United States, an estimated 5 million Americans over age 65 suffer from Alzheimer's disease, which is the US National Institute of Aging (National Institute on Aging) the sixth leading cause of death mentioned.
In the United States each year with Alzheimer's disease is directly related expenditures reached $ 203 billion, if the impact of the disease progression, delay disability-related aspects of dementia do not make a difference, by 2050, this figure is expected to increase to 10,000 One hundred million U.S. dollars. Hillary Clinton's campaign team noted that aggressive treatment of this disease is an effective way to help the government reduce the health insurance plans and health insurance burden.
2015年12月21日星期一
o-Chlorobenzalmalononitrile
Product name:o-Chlorobenzalmalononitrile
CAS: 2698-41-1
Molecular Formula:C10H5ClN2
Formula Weight: 188.61
Description:
Melting point:95 ºC
Boiling point:310-315 ºC
Flash point:148 ºC
Density:1.296 g/cm3
Chemical property:white crystalline solid with a peppery smell
Storage:In ventilate,cool and dry places.
from:http://www.acridine-raw-material.com/products/o-Chlorobenzalmalononitrile/
Bromo-DragonFLY for sale
Product name:Bromo-DragonFLY
CAS:502759-67-3
Molecular Formula:C13H12BrNO2
Molecular Weight:294.14g/mol
Description:Bromo-DragonFLY is a psychedelic hallucinogenic drug related to the phenethylamine family. Bromo-DragonFLY is considered an extremely potent hallucinogen, only slightly less potent than LSD with a normal dose in the region of 200 μg to 800 μg, and it has an extremely long duration of action up to several days.The hallucinogenic effect of bromo-DragonFLY is mediated by its agonist activity at the 5-HT2A serotonin receptor. Bromo-DragonFLY also has a high binding affinity for the 5-HT2B and 5-HT2C serotonin receptors, and is most accurately described as a non-subtype selective 5-HT2 agonist, as it is actually twice as potent an agonist for 5-HT2C receptors as for 5-HT2A, as well as being less than 5x selective for 5-HT2A over 5-HT2B.
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Amazing! Eating fish help burn fat?
A recent study found that fish oil can be stored fat cells into fat-burning cells, which may help curb weight gain in middle-aged. Research results were published in international journals scientific reports.
The researchers explained that fish oil can activate receptors in the digestive tract, activating the sympathetic nervous system, thereby inducing fat cells metabolize fat.
Not all fat tissue to store fat. White fat cells store fat can help maintain energy supply, while brown fat cells are primarily responsible for the metabolism of fat to maintain normal body temperature. Brown fat cells in the baby's body is relatively abundant, but decreased with age, most of adulthood brown fat will disappear.
Another fat cells - beige fat cells - a type of fat cells in humans and mice recently found, studies have shown fat cells beige brown fat cells have a similar function, such cells will increase with age growth reduction, without these burning fat cells, the fat will be piled up for decades and will not be consumed.
In this study, researchers for the intake of a particular type of food is to increase the number of beige fat cells were studied. The authors say: "We know from previous studies in some of the fish oil has many health benefits, including preventing the accumulation of fat, so we are on whether fish oil intake and beige fat increases an association has been studied."
The researchers carried out a group of mice fed the control diet, while another group on the basis of the control diet added fish oil, results showed that compared to the control group did not eat fish oil, fish oil 5% weight loss in mice 10%, fat content decreased by 15% to 25%. The researchers also found that when the sympathetic activation within white adipose tissue will form a new beige fat cells, increased fat consumption.
The researchers explained that fish oil can activate receptors in the digestive tract, activating the sympathetic nervous system, thereby inducing fat cells metabolize fat.
Not all fat tissue to store fat. White fat cells store fat can help maintain energy supply, while brown fat cells are primarily responsible for the metabolism of fat to maintain normal body temperature. Brown fat cells in the baby's body is relatively abundant, but decreased with age, most of adulthood brown fat will disappear.
Another fat cells - beige fat cells - a type of fat cells in humans and mice recently found, studies have shown fat cells beige brown fat cells have a similar function, such cells will increase with age growth reduction, without these burning fat cells, the fat will be piled up for decades and will not be consumed.
In this study, researchers for the intake of a particular type of food is to increase the number of beige fat cells were studied. The authors say: "We know from previous studies in some of the fish oil has many health benefits, including preventing the accumulation of fat, so we are on whether fish oil intake and beige fat increases an association has been studied."
The researchers carried out a group of mice fed the control diet, while another group on the basis of the control diet added fish oil, results showed that compared to the control group did not eat fish oil, fish oil 5% weight loss in mice 10%, fat content decreased by 15% to 25%. The researchers also found that when the sympathetic activation within white adipose tissue will form a new beige fat cells, increased fat consumption.
4-Azaindole for sale
Product name:4-Azaindole
CAS:272-49-1
Molecular Formula:C7H6N2
Molecular Weight:118.14g/mol
Description:Off-white Crystalline Powder.Melting point is 116~118°C.High Pressure Liquid Chromatography is ≥98.0%.
Would like to ask specific details, please click here Email:sales@chemicalspharm.com
University of California researchers said type 1 diabetes immunotherapy has great prospects
University of California, San Francisco researchers said on the 25th, a use of the patient's own immune cells immune therapy shows great promise in the treatment of type 1 diabetes in early clinical trials.
The researchers in the new issue of the day the American magazine "Science Translational Medicine" the report said, the use of this therapy in patients with type I diabetes blood regulation of immune cells called T cells, proving the safety of only Phase I clinical trials no serious side effects, and these cells can be present in the patient at least one year.
First author, UCSF professor Jeffrey Blue Stone said in a statement that if this new therapy can prove in further experiments in the protection of human insulin secretory capacity, then it will become "rules of the game-changer."
In Phase I clinical trials, the researchers first extracted from the body type 1 diabetes 2 small cups of blood, and then isolated from 2 million to 4 million of regulatory T cells in laboratory culture after 1500 times their number may increase. Blue Stone said, the activity of regulatory T cells cultured by such a process enhancements, fixes type I diabetics have defective immune responses, and prolonged survival in a patient.
The trial in 14 years to 43 years 18 patients were divided into four groups, receiving a varying number of autologous regulatory T cell injection, which is the minimum number 5000000 regulatory T cells, most are 2.6 billion regulatory T cells. The results showed that all four groups were well tolerated, and up to 25% of the cells over a year but also in the patient is detected.
Based on this result, the researchers are now ready to phase Ⅱ clinical trials to verify the effectiveness of this therapy. Blue Stone said: "The use of the patient's own cells are the new pillars of the drug development process exciting, and we look forward to regulatory T cells in the future become an important part of the treatment of diabetes."
The researchers in the new issue of the day the American magazine "Science Translational Medicine" the report said, the use of this therapy in patients with type I diabetes blood regulation of immune cells called T cells, proving the safety of only Phase I clinical trials no serious side effects, and these cells can be present in the patient at least one year.
First author, UCSF professor Jeffrey Blue Stone said in a statement that if this new therapy can prove in further experiments in the protection of human insulin secretory capacity, then it will become "rules of the game-changer."
In Phase I clinical trials, the researchers first extracted from the body type 1 diabetes 2 small cups of blood, and then isolated from 2 million to 4 million of regulatory T cells in laboratory culture after 1500 times their number may increase. Blue Stone said, the activity of regulatory T cells cultured by such a process enhancements, fixes type I diabetics have defective immune responses, and prolonged survival in a patient.
The trial in 14 years to 43 years 18 patients were divided into four groups, receiving a varying number of autologous regulatory T cell injection, which is the minimum number 5000000 regulatory T cells, most are 2.6 billion regulatory T cells. The results showed that all four groups were well tolerated, and up to 25% of the cells over a year but also in the patient is detected.
Based on this result, the researchers are now ready to phase Ⅱ clinical trials to verify the effectiveness of this therapy. Blue Stone said: "The use of the patient's own cells are the new pillars of the drug development process exciting, and we look forward to regulatory T cells in the future become an important part of the treatment of diabetes."
ETIZOLAM distinction where
Etizolam is a drug that is chemically similar to benzodiazepines and legal requirement in Japan, Italy and India. Sold under brand names including Depas, Etizest, Etizola, Sedekopan, Etilaam and Pasaden on the black market in the US and Europe, it is a potent drug and is also very addictive.
In countries where it is legal for use, etizolam is prescribed for treatment of insomnia and anxiety, similar to benzodiazepines (such as Xanax, Ativan, Valium) are here. Unfortunately, when the drug is used or misused without prescription, the result of an overdose, addiction and / or death can. Also, if etizolam combined with the use of alcohol, significantly increase these risks and the risk of accidents and other serious medical emergencies.
Etizolam
Etizolam currently not included in the Controlled Substances Act, but early research indicates that it is a very effective substance -. As much as 6-10 times as potent as diazepam (Valium for example) in clinical trials In addition, there were a number of "adverse effects" in the mode has also been reported, including:
Muscle weakness
Lack of coordination
Comfort
Unconsciousness
Headache
Drowsiness
Confusion
Slurred speech
Blurred vision
Changes in libido
Depression
Tremor or trembling
Because etizolam is not approved for medical use in the United States, any use of the drug is designated in this abuse of the country.
Alcohol
Although alcohol is readily available and most people in the US drink socially, alcohol is a poison and can have a strong impact on the body and the brain - both acute when the person under the influence and long-term regular use per year.
According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), alcohol has the following effects on the brain and body:
Alcohol interferes with the functioning of the brain, which in turn disrupts the ability of mood, behavior and coordination of the person to manage.
Fast or irregular heartbeat and high blood pressure are common when someone is drinking.
Alcohol has a negative effect on the liver and pancreas, especially if the beverage drinkers (eg, more than four drinks in one drinking session for women and more than five drinks in one drinking session for men) .
Alcohol consumption may reduce the immune system of the drinker himself vulnerable to making all kinds of diseases.
Even in small amounts, alcohol can person's ability to drive a vehicle behavior, think clearly and reduce manage.
The synergistic effect
When a person takes a drug which is combined and an effect similar to benzodiazepines (eg, etizolam) that drugs with alcohol, the effect is synergistic. In other words, the effect in the body when the substances to be combined is greater than the sum of the effects of the two, when taken separately. This means that someone has just a drink or two with a low dose of etizolam and overwhelmed; side effects both can be severe. Overdose, accident and life change bad decisions were made under the influence of a lot sooner if someone mixes all addictive prescription drugs with alcohol.
Treatment of drug abuse Poly
If someone you love has a drinking problem and combining with the use of other drugs - drugs like routine etizolam - treatment can help stop drinking and stop the use of all other substances of abuse. Learn more about how to ensure drinking high off your love today and always. Call now the future.
In countries where it is legal for use, etizolam is prescribed for treatment of insomnia and anxiety, similar to benzodiazepines (such as Xanax, Ativan, Valium) are here. Unfortunately, when the drug is used or misused without prescription, the result of an overdose, addiction and / or death can. Also, if etizolam combined with the use of alcohol, significantly increase these risks and the risk of accidents and other serious medical emergencies.
Etizolam
Etizolam currently not included in the Controlled Substances Act, but early research indicates that it is a very effective substance -. As much as 6-10 times as potent as diazepam (Valium for example) in clinical trials In addition, there were a number of "adverse effects" in the mode has also been reported, including:
Muscle weakness
Lack of coordination
Comfort
Unconsciousness
Headache
Drowsiness
Confusion
Slurred speech
Blurred vision
Changes in libido
Depression
Tremor or trembling
Because etizolam is not approved for medical use in the United States, any use of the drug is designated in this abuse of the country.
Alcohol
Although alcohol is readily available and most people in the US drink socially, alcohol is a poison and can have a strong impact on the body and the brain - both acute when the person under the influence and long-term regular use per year.
According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), alcohol has the following effects on the brain and body:
Alcohol interferes with the functioning of the brain, which in turn disrupts the ability of mood, behavior and coordination of the person to manage.
Fast or irregular heartbeat and high blood pressure are common when someone is drinking.
Alcohol has a negative effect on the liver and pancreas, especially if the beverage drinkers (eg, more than four drinks in one drinking session for women and more than five drinks in one drinking session for men) .
Alcohol consumption may reduce the immune system of the drinker himself vulnerable to making all kinds of diseases.
Even in small amounts, alcohol can person's ability to drive a vehicle behavior, think clearly and reduce manage.
The synergistic effect
When a person takes a drug which is combined and an effect similar to benzodiazepines (eg, etizolam) that drugs with alcohol, the effect is synergistic. In other words, the effect in the body when the substances to be combined is greater than the sum of the effects of the two, when taken separately. This means that someone has just a drink or two with a low dose of etizolam and overwhelmed; side effects both can be severe. Overdose, accident and life change bad decisions were made under the influence of a lot sooner if someone mixes all addictive prescription drugs with alcohol.
Treatment of drug abuse Poly
If someone you love has a drinking problem and combining with the use of other drugs - drugs like routine etizolam - treatment can help stop drinking and stop the use of all other substances of abuse. Learn more about how to ensure drinking high off your love today and always. Call now the future.
2015年12月20日星期日
$ 4,000,000,000! AstraZeneca announced the acquisition of Acerta 55% stake in the pharmaceutical
AstraZeneca will spread industry had $ 5 billion takeover rumors finally sit Acerta real difference is that the actual offer AstraZeneca is $ 4 billion, the acquisition of 55% stake Acerta. Acerta is a little-known biotechnology company, there were no drugs to the market, the main development of cancer and autoimmune related drugs. Acerta Currently in development of BTK inhibitors acalabrutinib has been granted FDA Orphan Drug treatment of mantle cell lymphoma qualify for a public analysts are optimistic.
Under the agreement, AstraZeneca will pay Acerta 25 亿 美元 advances, then approved by the FDA on or before the end of 2018, and then unconditionally pay $ 1.5 billion in acalabrutinib.
Under the agreement, AstraZeneca received only 55% of the shares Acerta, but AstraZeneca can still purchase the remaining 45% stake in the company by Acerta shareholders. AstraZeneca full acquisition Acerta specific time can not be determined, depending on acalabrutinib simultaneously approved in the US and Europe time. Once ripe, AstraZeneca intends to pay $ 3 billion net to acquire the remaining 45% stake.
Observe the agreement, not difficult to find acalabrutinib completely awful merger achievement core drugs. Currently acalabrutinib are all kinds of leukemia, lymphoma clinical trials, but also with Merck's tumor immune drugs Keytruda (pembrolizumab) carried out a joint drug test. Acalabrutinib BTK inhibitors are a class with Abbvie / Johnson leukemia drugs Imbruvica (ibrutinib) mechanism of action is similar, is generally considered peak sales will be more than 5 billion US dollars.
Early clinical data results Acalabrutinib also gratifying. Recently published in the New England Journal of Medicine Phase I / II clinical trial results showed that the response rate in patients with chronic lymphocytic leukemia drug has reached 95%, while adult leukemia, chronic lymphocytic leukemia is the most common one.
Under the agreement, AstraZeneca will pay Acerta 25 亿 美元 advances, then approved by the FDA on or before the end of 2018, and then unconditionally pay $ 1.5 billion in acalabrutinib.
Under the agreement, AstraZeneca received only 55% of the shares Acerta, but AstraZeneca can still purchase the remaining 45% stake in the company by Acerta shareholders. AstraZeneca full acquisition Acerta specific time can not be determined, depending on acalabrutinib simultaneously approved in the US and Europe time. Once ripe, AstraZeneca intends to pay $ 3 billion net to acquire the remaining 45% stake.
Observe the agreement, not difficult to find acalabrutinib completely awful merger achievement core drugs. Currently acalabrutinib are all kinds of leukemia, lymphoma clinical trials, but also with Merck's tumor immune drugs Keytruda (pembrolizumab) carried out a joint drug test. Acalabrutinib BTK inhibitors are a class with Abbvie / Johnson leukemia drugs Imbruvica (ibrutinib) mechanism of action is similar, is generally considered peak sales will be more than 5 billion US dollars.
Early clinical data results Acalabrutinib also gratifying. Recently published in the New England Journal of Medicine Phase I / II clinical trial results showed that the response rate in patients with chronic lymphocytic leukemia drug has reached 95%, while adult leukemia, chronic lymphocytic leukemia is the most common one.
2015 shook the man who is the biomedical sector?
Tu Yo Yo: 2015 Chinese scientific community most dazzling names, to achieve a breakthrough Chinese scientists the Nobel Prize. She makes the world more people feel the charm of traditional Chinese medicine.
September 2011, the discovery of artemisinin - a drug used to treat malaria, saving millions of lives the world, particularly in developing countries, Tu Yo Yo obtain a Nobel benchmark known Lasker Award . In June 2015, Tu Yo Yo was awarded the Warren Albert Award from Harvard University. October 2015, the Nobel Committee announced that China pharmacists Tu Yo Yo obtain fiscal 2015 Nobel Prize in Physiology or Medicine.
Perseverance, perseverance is committed to antimalarial drug research, discovery of artemisinin antimalarial international made important contributions. In Tu Yo Yo who embodies the Chinese scientists noble feelings and tirelessly for the people of science stick.
September 2011, the discovery of artemisinin - a drug used to treat malaria, saving millions of lives the world, particularly in developing countries, Tu Yo Yo obtain a Nobel benchmark known Lasker Award . In June 2015, Tu Yo Yo was awarded the Warren Albert Award from Harvard University. October 2015, the Nobel Committee announced that China pharmacists Tu Yo Yo obtain fiscal 2015 Nobel Prize in Physiology or Medicine.
Perseverance, perseverance is committed to antimalarial drug research, discovery of artemisinin antimalarial international made important contributions. In Tu Yo Yo who embodies the Chinese scientists noble feelings and tirelessly for the people of science stick.
Yo Yo Tu Artemisinin of Artesunate
Artemisinin can be used alone, but it has been very high and other reasons leading to relapse (return) and other parasites varieties of drugs, people must remove all parasites, as well as to prevent similar incidents from happening again. World Health Organization (WHO) forces manufacturers will stop making the drug available for non-complex medical community attributes, Mara artemisinin resistant malaria parasites RIA aware of disaster situation was under development.
Who recommends artemisinin combination therapy (action) in the treatment of first-line drugs falciparum malaria. Artemisinin combination of ingredients because the parasite will kill most effective treatment, while the remaining pair to clear the slower clearance of the drug at the beginning of parasites.
Inotropic agents and partners a very long half-life of several behavior is now available fixed-dose artemisinin-containing composition is highly selective, such as mefloquine abnormal black Munziq, lumefantrine (Coartem ), amodiaquine (pulp), piperaquine high-tech drugs "Ketai new" (double), and Pyronaridine Pyramax (). Increasingly, these combinations, so make the GMP standard. A separate issue, relations to education, the quality of teaching is good or bad some of artemisinin-containing products are exported to Africa and Southeast Asia.
Product name:Artesunate
CAS: 88495-63-0
Molecular Formula:C19H28O8
Formula Weight: 384.42
Description:
Artesunate (INN) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS.
Artesunate is used primarily as treatment for malaria; but it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection
Would like to ask specific details, please click here Email:sales@acridine-raw-material.com
Who recommends artemisinin combination therapy (action) in the treatment of first-line drugs falciparum malaria. Artemisinin combination of ingredients because the parasite will kill most effective treatment, while the remaining pair to clear the slower clearance of the drug at the beginning of parasites.
Inotropic agents and partners a very long half-life of several behavior is now available fixed-dose artemisinin-containing composition is highly selective, such as mefloquine abnormal black Munziq, lumefantrine (Coartem ), amodiaquine (pulp), piperaquine high-tech drugs "Ketai new" (double), and Pyronaridine Pyramax (). Increasingly, these combinations, so make the GMP standard. A separate issue, relations to education, the quality of teaching is good or bad some of artemisinin-containing products are exported to Africa and Southeast Asia.
Product name:Artesunate
CAS: 88495-63-0
Molecular Formula:C19H28O8
Formula Weight: 384.42
Description:
Artesunate (INN) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS.
Artesunate is used primarily as treatment for malaria; but it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection
Would like to ask specific details, please click here Email:sales@acridine-raw-material.com
2015 top ten scientific breakthroughs released: "gene scissors" topped
American magazine "Science" on the 17th announced its selection of the 2015 top ten scientific breakthroughs, the industry as "gene scissors" of CRISPR genome editing technology breakthrough was elected number one this year.
"Science" magazine Executive News Editor John Travis said it was an "unprecedented choice", because the technology in the past two appeared in the "science" Ten breakthrough year, this year's "promoted" to number one breakthrough.
CRISPR full-called "clusters, regularly spaced short palindromic repeats," is a defense mechanism of bacterial viruses, and in 2012 was only scientists discovered and exploited, became the first biomedical efficiently and accurately , programmatically modify the genome of a cell including the human genome tools.
"Science" magazine said, because CRISPR with precise, low cost and simple operation, many research institutions have started development and utilization of this technology, it "will bring lasting excitement and optimism to many areas," bound "to study have a revolutionary impact. "
This year nine other groundbreaking scientific achievements include:
"New Horizons" Pluto probe "dating": the United States, "New Horizons" spacecraft in January 2006 launch, after 9 years of chasing up, it flew close to the United States Eastern time on July 14 over Pluto, became the first probe Fengyun distant dwarf planet human detector.
There lymphatic brain: The lymphatic system is a mesh of liquid system, can help clean up the body of waste and transport immune cells. This year, scientists discovered that the immune system of lymphatic vessels connected in the brain of mice, subversion decades textbook "no lymphatic brain" of old ideas.
Painkillers with yeast synthetic opioids; opioids is the best analgesic effect of a drug, but it is the only source of opium poppy, and therefore their production is dependent on poppy cultivation. US scientists have genetically engineered yeast transformation, the sugar can be converted into thebaine, which is used to produce opioid analgesics.
Quantum entanglement status been confirmed: The concept that two particles can affect spatially separated from each other, regardless of the distance between them is. Measure the properties of a particle, it can immediately determine the nature of another particle. Einstein refused to accept this "spooky remote effect", because he made it with no movement speed of any substance can exceed the speed of light theory of conflict. But this year the scientists experimentally confirmed that quantum entanglement state.
Plume exists evidence is found: For the existence of mantle plumes has been debated for 40 years, supporters believe that mantle plumes heat transport to the center of the earth surface, could explain the reason Hawaii Volcanoes formed in the middle of the tectonic plates. This year, scientists using improved seismic imaging techniques to map out the highest accuracy so far inside the earth simulation diagram, found evidence of 28 plume exists. These mantle plume 800 kilometers wide, it is more than three times the previous forecast, and therefore core cooling models may need to be amended.
Ebola vaccine developed: Ebola vaccine drug development progress and overall disappointing, but by the Public Health Agency of Canada and other institutions to develop the VSV-EBOV Ebola vaccine Phase III clinical trial results are encouraging, the protective effect mediated between 75 to 100%.
Improve psychological research: Many psychology experiments can not be repeated, but now a solution proposed is "pre-registration", that is published before making experiments on experimental program, regardless of the outcome we will announce the final results and statistical analysis to ensure Experimental transparency, avoid the researchers that only part of the data selected advantageously.
New species of ancient fossils: an international team in the depths of a cave in South Africa more than 1500 bones excavated fossils, these fossils unusual mix of hominids and modern humans characteristics. Scientists named this new race "纳莱迪 people", he is one of the oldest races now discover.
Early American people from Asia: researchers on a program called Kennewick bones were human genome sequencing, the bones dating back 8500 years. Sequence analysis showed that early man migrated from the Americas from Asia. The research may help quell the controversy related to the early American ancestors.
"Science" magazine Executive News Editor John Travis said it was an "unprecedented choice", because the technology in the past two appeared in the "science" Ten breakthrough year, this year's "promoted" to number one breakthrough.
CRISPR full-called "clusters, regularly spaced short palindromic repeats," is a defense mechanism of bacterial viruses, and in 2012 was only scientists discovered and exploited, became the first biomedical efficiently and accurately , programmatically modify the genome of a cell including the human genome tools.
"Science" magazine said, because CRISPR with precise, low cost and simple operation, many research institutions have started development and utilization of this technology, it "will bring lasting excitement and optimism to many areas," bound "to study have a revolutionary impact. "
This year nine other groundbreaking scientific achievements include:
"New Horizons" Pluto probe "dating": the United States, "New Horizons" spacecraft in January 2006 launch, after 9 years of chasing up, it flew close to the United States Eastern time on July 14 over Pluto, became the first probe Fengyun distant dwarf planet human detector.
There lymphatic brain: The lymphatic system is a mesh of liquid system, can help clean up the body of waste and transport immune cells. This year, scientists discovered that the immune system of lymphatic vessels connected in the brain of mice, subversion decades textbook "no lymphatic brain" of old ideas.
Painkillers with yeast synthetic opioids; opioids is the best analgesic effect of a drug, but it is the only source of opium poppy, and therefore their production is dependent on poppy cultivation. US scientists have genetically engineered yeast transformation, the sugar can be converted into thebaine, which is used to produce opioid analgesics.
Quantum entanglement status been confirmed: The concept that two particles can affect spatially separated from each other, regardless of the distance between them is. Measure the properties of a particle, it can immediately determine the nature of another particle. Einstein refused to accept this "spooky remote effect", because he made it with no movement speed of any substance can exceed the speed of light theory of conflict. But this year the scientists experimentally confirmed that quantum entanglement state.
Plume exists evidence is found: For the existence of mantle plumes has been debated for 40 years, supporters believe that mantle plumes heat transport to the center of the earth surface, could explain the reason Hawaii Volcanoes formed in the middle of the tectonic plates. This year, scientists using improved seismic imaging techniques to map out the highest accuracy so far inside the earth simulation diagram, found evidence of 28 plume exists. These mantle plume 800 kilometers wide, it is more than three times the previous forecast, and therefore core cooling models may need to be amended.
Ebola vaccine developed: Ebola vaccine drug development progress and overall disappointing, but by the Public Health Agency of Canada and other institutions to develop the VSV-EBOV Ebola vaccine Phase III clinical trial results are encouraging, the protective effect mediated between 75 to 100%.
Improve psychological research: Many psychology experiments can not be repeated, but now a solution proposed is "pre-registration", that is published before making experiments on experimental program, regardless of the outcome we will announce the final results and statistical analysis to ensure Experimental transparency, avoid the researchers that only part of the data selected advantageously.
New species of ancient fossils: an international team in the depths of a cave in South Africa more than 1500 bones excavated fossils, these fossils unusual mix of hominids and modern humans characteristics. Scientists named this new race "纳莱迪 people", he is one of the oldest races now discover.
Early American people from Asia: researchers on a program called Kennewick bones were human genome sequencing, the bones dating back 8500 years. Sequence analysis showed that early man migrated from the Americas from Asia. The research may help quell the controversy related to the early American ancestors.
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