It is well known that the placenta can secrete soluble factors to affect the metabolism of the fetus, the placenta and the mother, but in addition to these soluble regulating substance, placental cells (including cell trophoblast cells, syncytiotrophoblast and placenta derived mesenchymal stem cells) can also be by releasing some of extracellular vesicles (ECVs- including apoptotic bodies / vesicles (100-600 nm); shed microvilli (.400 nm); micro vesicles (0.1-2 mm); exosomes (30 -100 nm)), and thus have an impact on the mother and fetus. ECVs placenta sources (including exosomes and micro vesicles) in normal pregnancy can be detected in maternal plasma, these ECVs contain placenta-specific proteins and miRNA, and may be the parent secreted exosomes are distinguished .
Study subjects were divided into four groups, namely non-pregnant women, pregnant women in early pregnancy that is the first three months (FT-first trimester, pregnant 6-12 weeks), namely pregnant women in the second trimester of three months (ST-second trimester, pregnant 22-24 weeks), that is three months after the third trimester pregnant women (TT-third trimester, pregnant 32-38 weeks), to detect these human plasma exosomes.
2016年2月24日星期三
Glucono-Delta-Lactone
Product name: Glucono-Delta-Lactone
CAS no.: 90-80-2
Molecular Formula: C6H10O6
Molecular Weight: 178.14
Appearance: white crystal or crystalline powder
Product description: Used as a protein solidifier, sour agent, bulking agent, preservative and cosmetics, toothpaste production.
Tinocare GL
Product name:Tinocare GL
Description:TINOCARE GL, a polysaccharide is a scleroglucan member of the SS-glucan family. It retains moisture in the skin naturally and improves the sensory properties of personal care formulations. Retains moisture in the skin and naturally improves sensory properties of personal care formulations. Used in skin, hair and oral care and bath products and shower.
Doxycycline monohydrate
Product name: Doxycycline monohydrate
CAS no.: 17086-28-1
Molecular Formula: C22H26N2O9
Molecular Weight: 462.45
Product description: For anti-infection drugs.
For more, please click:http://www.chemicalspharm.com/New-Products/
Buffered Peptone Water
Product name:Buffered Peptone Water
Packing(g/bottle):250
Product description:
Buffered Peptone Water is intended to aid in the recovery of injured Salmonella species from foods and other samples prior to selective enrichment and isolation.
A new method of HIV research in Germany to clear
German researchers February 22 reported that they are developing a new approach is expected to help patients remove HIV from the body. Currently animal experiments have been successful.
HIV and other retroviruses, when breeding their genetic material will be integrated into the genome of the human host to replicate. Although antiretroviral therapy can effectively inhibit the reproduction of HIV, but the virus can not eradicate this type of integration. Therefore, the virus can lie dormant dormant during treatment, discontinuation of treatment once, again to start copying.
Dresden University of Technology said a press release the same day, the school in cooperation with the Heinrich Pater Hamburg Institute researchers, the use of an important tool for protein engineered "directed molecular evolution" developed a method called Brec1 recombinase. Cell specimens and test tubes in mice show that the recombinase can accurately identify the location of more than 90% of common clinical HIV strains, and can safely and accurately in the genome of infected cells completely "cut off" integrated provirus.
The so-called provirus, is present in the host chromosome, potential virus genome. Further experiments showed that this method does not destroy the function of the host cell and the normal gene. After the original virus is cleared by HIV genetic material interference and malfunction of the immune system is expected to return to normal.
The researchers say that this method is expected to bring fundamental changes to HIV treatment, so completely cure possible. In the current basis of animal experiments, the researchers have been granted preliminary clinical trials in the next body of AIDS patients.
HIV and other retroviruses, when breeding their genetic material will be integrated into the genome of the human host to replicate. Although antiretroviral therapy can effectively inhibit the reproduction of HIV, but the virus can not eradicate this type of integration. Therefore, the virus can lie dormant dormant during treatment, discontinuation of treatment once, again to start copying.
Dresden University of Technology said a press release the same day, the school in cooperation with the Heinrich Pater Hamburg Institute researchers, the use of an important tool for protein engineered "directed molecular evolution" developed a method called Brec1 recombinase. Cell specimens and test tubes in mice show that the recombinase can accurately identify the location of more than 90% of common clinical HIV strains, and can safely and accurately in the genome of infected cells completely "cut off" integrated provirus.
The so-called provirus, is present in the host chromosome, potential virus genome. Further experiments showed that this method does not destroy the function of the host cell and the normal gene. After the original virus is cleared by HIV genetic material interference and malfunction of the immune system is expected to return to normal.
The researchers say that this method is expected to bring fundamental changes to HIV treatment, so completely cure possible. In the current basis of animal experiments, the researchers have been granted preliminary clinical trials in the next body of AIDS patients.
2016年2月23日星期二
Ulinastatin
A Kunitz-type serine protease inhibitor multivalent human urine derived, with a potential, anti-fibrinolytic and anticoagulant activities. When administered, ulinastatin (urine or trypsinogen inhibitor) inhibits the activity of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin , lipase, hyaluronidase, factors IXa, Xa, XIa and Xian, and polymorphonuclear leukocyte elastase. Moreover, ulinastatin inhibits excessive release of pro-inflammatory mediators such as tumor-necrosis factor alpha, interleukin-6 and -8, and chemokines. Overall, these agents can improve microcirculation, blood flow and function of the tissue and may protect organ damage.
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