There are no reliable and accurate method for the early termination of pregnancy in rabbits. Thus, this study was conducted to determine the effect of
aglepristone administration in the prevention of early pregnancy before the implantation of this species. Twenty-two animals (aged 10-12 months, the New Zealand White rabbits) were naturally mated and pregnancy was in all animals by ultrasound at day 6 after mating (5-7.5 MHz transducer network Sonostar linear Dynamic Imaging, UK) and confirmed (10 mg / kg, subcutaneous Alizin, Virbac) 6 and 7 days was injected twice, 24 hours apart after aglepristone coupling (n = 5 ; n = 8): group I and group III: the animals were grouped at random. Group II and Group IV: The same volume of solution of NaCl 0.9% was injected subcutaneously in the same range and served as a control group (n = 5, n = 3). ultrasound examination of the uterus was daily 7 days conducted to test the efficacy on day 11 after mating aglepristone. Blood samples were collected between days 6 and 30, centrifuged at 3070 g for 10 minutes at -20 degrees C. The whole aglepristone stored groups (Group I, III) are not pregnant, whereas all animals control group were pregnant (group II, IV). This makes the Group I and III were examined clinically and ultrasound only; were, however, control the sites of countable implantation after pairing in Groups III and IV laparomized days 6, 7, 9 and 11. No implantation sites were in Group III, while were clearly seen in the IV group. No side effects were observed. The mean serum progesterone (P4) concentrations were not significantly different between the treated and control means (p> 0.05). The results show that the treatment could prevent aglepristone days 6 and 7 after mating, pregnancy after unwanted pairings without side effects in rabbits. Aglepristone treatments can affect fertility not before implantation.
