Product Name: Nodakenin
CAS: 495-31-8
Molecular formula: Nodakenin
Molecular Weight: 408.3992
Product Description: Nodakenin is a compound coumarin originally isolated from the roots of Angelica gigas. In this study, we investigated the effects of nodakenin on learning and memory impairment induced by scopolamine (1 mg / kg, ip) using the passive avoidance test, the maze test Y, and test Morris water maze in mice. Nodakenin (10 mg / kg, po) administration reversed significantly cognitive impairment induced by scopolamine in the passive avoidance test and the test Y maze (P <0.05), and also escape latency during the training in the test Morris water maze (P reduced <0.05). In addition, in the target area of the aquatic labyrinth time and Morris distances longer swim in the nodakenin treated group than in the group treated scopolamine (P <0.05). In an in vitro study found nodakenin acetylcholinesterase activity inhibition in a dose dependent manner (IC (50) = 84.7 microM). Moreover nodakenin of acetylcholinesterase activity for 6 was also inhibit h in an ex vivo study. These results suggest that a box nodakenin be useful for the treatment of cognitive disorders, and its beneficial effects are mediated in part on enhancing cholinergic signaling.
