In this double-blind study, 97 patients who had received treatment zidovudine for at least six months with HIV, and 50 to 400 CD4 cells per cubic millimeter, and at least 20,000 HIV RNA copies per milliliter had a randomly were assigned to three treatments for 52 weeks: 800 mg indinavir every eight hours; 200 mg zidovudine 150 mg every eight hours with lamivudine twice daily in combination; or all three drugs. Patients had to monitor the occurrence of adverse events and changes in viral load and CD4 cell count.
RESULTS:
The decrease in HIV RNA during the first 24 weeks were higher in the group of three drugs in other groups (p <0.001 for each comparison). RNA levels dropped to less than 500 copies per milliliter at week 24 in 28 of 31 patients in the group of three drugs (90 percent), 12 of 28 patients in the indinavir group (43 percent), and none of the 30 patients in the zidovudine group -lamivudine. Increasing the number of CD4 cells during the first 24 weeks was higher in the two groups receiving indinavir than in the zidovudine-lamivudine group (P <or = 0.01 for each comparison). Changes in viral load and CD4 count remained until 52 weeks. All doses were generally well tolerated.
CONCLUSION:
In most patients with HIV infection with antiretroviral therapy before, the combination of indinavir, zidovudine, lamivudine, and reduced levels of HIV RNA to less than 500 copies per milliliter for as long as one year.
2016年6月29日星期三
Ketanserin price
Product name: ketanserin
CAS: 74050-98-9
Molecular formula: C22H22FN3O3
Molecular Weight: 395.4268
Product Description: This product is 5 - receptor blockers of serotonin, selective blockade of serotonin 5-HT2, are weaker and H receptor antagonist. Do you have a decrease in blood pressure in patients with peripheral resistance, decreased the apparent renal vascular resistance, normal for the function. With vascular obstructive lesions of blood supply of the lower limbs can improve. For Renault tissue perfusion can improve disease increased blood flow to the skin. After intravenous injection, right atrial pressure, pulmonary artery pressure and pulmonary capillary pressure can reduce stress.
2016年6月27日星期一
What is Fluoxetine
Product Name: fluoxetine
CAS: 54910-89-3
Molecular formula: C17H18F3NO
Molecular Weight: 309.33
Product Description: A kind of serotonin reuptake inhibitors, through synaptic cells of the neurotransmitter serotonin reuptake inhibition to increase levels of serotonin post-synaptic receptors can and extracellular. And for other receptors such as alpha adrenergic, beta adrenergic, serotonin, dopamine can wait, fluoxetine is almost no force.Well link from the gastrointestinal tract after oral consumption, the food will not affect its bioavailability. In combination with the many plasma proteins after absorption, is widespread. The drugs reach plasma concentrations at steady state after a few weeks.
CAS: 54910-89-3
Molecular formula: C17H18F3NO
Molecular Weight: 309.33
Product Description: A kind of serotonin reuptake inhibitors, through synaptic cells of the neurotransmitter serotonin reuptake inhibition to increase levels of serotonin post-synaptic receptors can and extracellular. And for other receptors such as alpha adrenergic, beta adrenergic, serotonin, dopamine can wait, fluoxetine is almost no force.Well link from the gastrointestinal tract after oral consumption, the food will not affect its bioavailability. In combination with the many plasma proteins after absorption, is widespread. The drugs reach plasma concentrations at steady state after a few weeks.
Indinavir for sale
Product Name: indinavir
CAS: 150378-17-9
Molecular formula: C9H13N3O3
Molecular Weight: 711.88
Product description: indications and in combination with other antiretroviral drugs is used, used in the treatment of adults and children infected with HIV - 1 clinical studies showed adults: the spread of HIV / AIDS to slow down a process or die - to increase serum RNA virus in low - - risk of persistence of overall survival allows higher CD4 cell number is persistence
CAS: 150378-17-9
Molecular formula: C9H13N3O3
Molecular Weight: 711.88
Product description: indications and in combination with other antiretroviral drugs is used, used in the treatment of adults and children infected with HIV - 1 clinical studies showed adults: the spread of HIV / AIDS to slow down a process or die - to increase serum RNA virus in low - - risk of persistence of overall survival allows higher CD4 cell number is persistence
Indosine Pranobeox price
Product Name: Indosine Pranobeox
CAS: 36703-88-5
Molecular formula: C24H34N6O9
Molecular Weight: 550.5616
Product Description: With anti-viral and anti-cancer activity in the body, clinical double-blind studies indicate that isopropyl inosine can reduce oral different viral infection (such as influenza, chicken pox, measles, mumps and several stomatitis, etc.), the duration and severity of the disease. This product is significantly superior to placebo for HIV / AIDS and tumor recovery of immune function, the patient. Isopropyl inosine tablets or eye drops may keratitis herpes virus, signs and symptoms of uveitis than placebo has a great improvement, this product is suitable for taking your metabolism fast side effects, light.
CAS: 36703-88-5
Molecular formula: C24H34N6O9
Molecular Weight: 550.5616
Product Description: With anti-viral and anti-cancer activity in the body, clinical double-blind studies indicate that isopropyl inosine can reduce oral different viral infection (such as influenza, chicken pox, measles, mumps and several stomatitis, etc.), the duration and severity of the disease. This product is significantly superior to placebo for HIV / AIDS and tumor recovery of immune function, the patient. Isopropyl inosine tablets or eye drops may keratitis herpes virus, signs and symptoms of uveitis than placebo has a great improvement, this product is suitable for taking your metabolism fast side effects, light.
Manufacture of 3-Fluorobenzenamine price
Product Name: Manufacture of 3-Fluorobenzenamine
CAS: 372-19-0
Molecular formula: C6H6FN
Molecular Weight: 111.12
Melting point: 34.6 ℃
Flash Point: 77 ℃
Appearance and properties: Light yellow liquid
Application: Used in the manufacture of pharmaceuticals, pesticides, agricultural chemicals, as well as azo dyes and pigment intermediates.
CAS: 372-19-0
Molecular formula: C6H6FN
Molecular Weight: 111.12
Melting point: 34.6 ℃
Flash Point: 77 ℃
Appearance and properties: Light yellow liquid
Application: Used in the manufacture of pharmaceuticals, pesticides, agricultural chemicals, as well as azo dyes and pigment intermediates.
High quality Brinzolamide for sale
Product Name: High quality brinzolamide
CAS: 138890-62-7
Molecular formula: C12H21N3O5S3
Molecular Weight: 383.51
Density: 1.5 g / cm3
Boiling point: 586 ℃ to 760 mmHg
Flash Point: 308.2 ° C
Refractive Index: 1.625
Type: Small Molecule
Product description: High qulity brinzolamide is a non-competitive, reversible Carboanhydrasehemmer very specific. carbonic anhydrase (CA) is an enzyme which in many tissues of the body, including the eye. It catalyzes the reversible reaction, the hydrogenation of carbon dioxide and the dehydration of carbonic acid are involved. In humans, there is carbonic anhydrase as a number of isoenzymes, the highest active carbonic anhydrase II (CA-II). Inhibition of carbonic anhydrase in the ciliary processes of the eye by decreasing aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure. Brinzolamide is indicated for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
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