Epothilone D affects cell cycle

Epothilones, macrocyclic lactones from the culture of Sorangium cellulosum Myxobacteriums are designated in human medicine as taxol-like microtubule drugs. To date, nothing is known about the effect of epothilones on known microtubules (MT) in plant cells and / or on the cell cycle of the plant. As shown in this report, processing tomatoes cell cultures in suspension with epothilone D to a continuous increase in the mitotic index. Dose-response curves have shown that epothilone D alters the mitotic index in concentrations as low as 1.5 MikroM. Mitochondrial arrest was observed after treatment only 2 hours and 55% of the cells were discontinued after 24 hours. As shown by immunozytologic methods occur during metaphase abnormal spindles, which leads to a random distribution of chromosomes throughout the cell and prevent the formation of a metaphase plate. The chromosomal de-condensation process does not appear to be affected, since the formation of micronuclei in the same place with the distributed chromosomes. This suggests that the stability of epothilone D influenced plant MTs mainly during the metaphase of a mitotic cycle. In metaphase, the effects of epothilone D appear to be irreversible, as cells with an abnormal pin could not be recovered after drug elimination.

Epothilone D for sale

Product: epothilones D
CAS: 189453-10 & ndash; 9
Molecular Formula: C27H41NO5S
Appearance: colorless powder
Purity: 99%
Storage: Avoid sunlight, keep dry
Product Description: Epothilone D is a natural Polyketidverbindung that has been isolated from cellulosum myxobacterium Sorangium. Also known as deoxyepothilone B known epothilone D binds to tubulin and prevents disassembly of microtubules, leading to inhibition of mitosis, cell proliferation and cellular motility.

What is Anhydroxylitol

Product: anhydroxylitol
CAS: 87-99-0
Molecular formula: C5H12O5
Molecular Weight: 152.15
Appearance: Crystal white or crystalline powder
Purity: 99%
Storage: Avoid sunlight, keep dry
Product Description: Anhydroxylitol is a molecule that belongs to primary hydroxyl groups, amines and carboxyl groups. It is considered a natural sugar, which can collect and enclose water molecules, in order to stimulate hyaluronic acid.

Alpha-methyldopa price

Product Name: alpha-methyldopa
CAS: 555-30-6
Molecular formula: C10H13NO4
Molecular Weight: 211.21
Appearance: White crystalline powder
Purity: 99%
Storage: Avoid sunlight, keep dry
Product Description: Alpha-methyldopa is a drug that is used for high blood pressure. It is one of the preferred treatments for pregnancy hypertension. For other types of high blood pressure, including high blood pressure, which may be symptoms of other drugs usually preferred. It can be administered orally or by injection into a vein.

Drostanolone Propionate pirce

Product Name: Drostanolone Propionate
CAS: 58-19-5
Molecular Formula: C23H36O3
Molecular Weight: 360.53
Appearance: white powder
Purity: 99%
Storage: Avoid sunlight, keep dry
Product Description: Propionate Drostanolone can muscle hardness and an increase in density, so that the individual gets a better appearance to the competition on stage. However, a body fat level already low enough is necessary for it to be fully effective.

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Product Name: Hydroxypropyl chitosan
Appearance: white powder
Purity: 99%
Storage: Avoid sunlight, keep dry
Product description: Hydroxypropyl chitosan is a derivative of chitosan with a good property soluble in water, modified from a chitosan. The aqueous solution of chitosan hydroxypropyl is neutral and this chitosan has a good emulsifier, antibacterial, hygroscopic, moisturizing and bacteriostatic properties and a good surface activity, etc.

Dalbavancin price

Product: dalbavancin
CAS: 171500-79-1
Molecular formula: C88H100Cl2N10O28
Molecular Weight: 1816.7
Appearance: white powder
Purity: 99%
Storage: Avoid sunlight, keep dry
Product Description: dalbavancin is an antibiotic used to treat bacterial infections of skin structure and acute skin (ABSSSI) in adults caused by susceptible Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) . MRSA infections have become problematic in the community and in health care because of resistance to many antibiotics available.