American magazine "Science" on the 17th announced its selection of the 2015 top ten scientific breakthroughs, the industry as "gene scissors" of CRISPR genome editing technology breakthrough was elected number one this year.
"Science" magazine Executive News Editor John Travis said it was an "unprecedented choice", because the technology in the past two appeared in the "science" Ten breakthrough year, this year's "promoted" to number one breakthrough.
CRISPR full-called "clusters, regularly spaced short palindromic repeats," is a defense mechanism of bacterial viruses, and in 2012 was only scientists discovered and exploited, became the first biomedical efficiently and accurately , programmatically modify the genome of a cell including the human genome tools.
"Science" magazine said, because CRISPR with precise, low cost and simple operation, many research institutions have started development and utilization of this technology, it "will bring lasting excitement and optimism to many areas," bound "to study have a revolutionary impact. "
This year nine other groundbreaking scientific achievements include:
"New Horizons" Pluto probe "dating": the United States, "New Horizons" spacecraft in January 2006 launch, after 9 years of chasing up, it flew close to the United States Eastern time on July 14 over Pluto, became the first probe Fengyun distant dwarf planet human detector.
There lymphatic brain: The lymphatic system is a mesh of liquid system, can help clean up the body of waste and transport immune cells. This year, scientists discovered that the immune system of lymphatic vessels connected in the brain of mice, subversion decades textbook "no lymphatic brain" of old ideas.
Painkillers with yeast synthetic opioids; opioids is the best analgesic effect of a drug, but it is the only source of opium poppy, and therefore their production is dependent on poppy cultivation. US scientists have genetically engineered yeast transformation, the sugar can be converted into thebaine, which is used to produce opioid analgesics.
Quantum entanglement status been confirmed: The concept that two particles can affect spatially separated from each other, regardless of the distance between them is. Measure the properties of a particle, it can immediately determine the nature of another particle. Einstein refused to accept this "spooky remote effect", because he made it with no movement speed of any substance can exceed the speed of light theory of conflict. But this year the scientists experimentally confirmed that quantum entanglement state.
Plume exists evidence is found: For the existence of mantle plumes has been debated for 40 years, supporters believe that mantle plumes heat transport to the center of the earth surface, could explain the reason Hawaii Volcanoes formed in the middle of the tectonic plates. This year, scientists using improved seismic imaging techniques to map out the highest accuracy so far inside the earth simulation diagram, found evidence of 28 plume exists. These mantle plume 800 kilometers wide, it is more than three times the previous forecast, and therefore core cooling models may need to be amended.
Ebola vaccine developed: Ebola vaccine drug development progress and overall disappointing, but by the Public Health Agency of Canada and other institutions to develop the VSV-EBOV Ebola vaccine Phase III clinical trial results are encouraging, the protective effect mediated between 75 to 100%.
Improve psychological research: Many psychology experiments can not be repeated, but now a solution proposed is "pre-registration", that is published before making experiments on experimental program, regardless of the outcome we will announce the final results and statistical analysis to ensure Experimental transparency, avoid the researchers that only part of the data selected advantageously.
New species of ancient fossils: an international team in the depths of a cave in South Africa more than 1500 bones excavated fossils, these fossils unusual mix of hominids and modern humans characteristics. Scientists named this new race "纳莱迪 people", he is one of the oldest races now discover.
Early American people from Asia: researchers on a program called Kennewick bones were human genome sequencing, the bones dating back 8500 years. Sequence analysis showed that early man migrated from the Americas from Asia. The research may help quell the controversy related to the early American ancestors.
2015年12月20日星期日
2015年12月18日星期五
Scientists explain before Google's innovative technology Verb surgical robot
Verb Surgical company has been quietly planning to develop a new generation of surgical robots, since March collaboration with Johnson & Johnson, which is only part of the details of the cooperation, but now, a scientist Babak Parviz before Google's ongoing development of new technologies, and It provides a rare opportunity for the company's most innovative process. 2010, Babak Parviz worked at Amazon company, Amazon has joined the Alphabet of Google X department for the development of Google glasses wearable computer, but it also put forward some ideas developed for the operating room of the robot, which one Plan is to create autonomous surgical robot to perform surgical procedures through the joystick, while assisting surgeons completed surgical procedure.
Parviz told Medium site, we rely on the surgeon's dexterity, but now we know that manual operation more accurate than the machine, and the use of the machine may be able to provide adequate opportunity for the surgeon to perform the surgery, but no longer like before use hands to complete the surgical procedure. Robot surgery can help for quick surgical procedure, and produces a more rapid response time, traditional surgical fundamentally limited by the human decision-making time, but also limited the duration of treatment of human operation of the instrument, while surgical robot You can solve many problems, it can more quickly help repair vascular and other surgical operations.
At present this technology to developing countries have a greater value, Verb companies seem to see the researcher Babak Parviz early ideas, the company recently said that their aim is to develop a comprehensive surgical solution to platform or frontier The robots ability and first-class medical device technology integration in the laboratory. Global Chairman of Johnson & Johnson medical device company Gary Pruden said in a statement that, we believe, Verb Surgical Company has the potential to change the future of surgery, and not just robotic surgery, the research team is currently in the development of robotic platform has been made substantive progress.
Involved in the field of robotics surgery can help Verily small fortune in the growing market, as of 2021 surgical robotics market will increase to $ 20 billion, other companies, such as Intuitive Surgical and Stryker companies currently in this area also We have made tremendous progress. Verb future in the field of surgical robotics technology still has a long way to go, I believe that in the near future, our surgeons can make timely decisions, but surgical robot to operate according to the surgeon's decision.
Parviz told Medium site, we rely on the surgeon's dexterity, but now we know that manual operation more accurate than the machine, and the use of the machine may be able to provide adequate opportunity for the surgeon to perform the surgery, but no longer like before use hands to complete the surgical procedure. Robot surgery can help for quick surgical procedure, and produces a more rapid response time, traditional surgical fundamentally limited by the human decision-making time, but also limited the duration of treatment of human operation of the instrument, while surgical robot You can solve many problems, it can more quickly help repair vascular and other surgical operations.
At present this technology to developing countries have a greater value, Verb companies seem to see the researcher Babak Parviz early ideas, the company recently said that their aim is to develop a comprehensive surgical solution to platform or frontier The robots ability and first-class medical device technology integration in the laboratory. Global Chairman of Johnson & Johnson medical device company Gary Pruden said in a statement that, we believe, Verb Surgical Company has the potential to change the future of surgery, and not just robotic surgery, the research team is currently in the development of robotic platform has been made substantive progress.
Involved in the field of robotics surgery can help Verily small fortune in the growing market, as of 2021 surgical robotics market will increase to $ 20 billion, other companies, such as Intuitive Surgical and Stryker companies currently in this area also We have made tremendous progress. Verb future in the field of surgical robotics technology still has a long way to go, I believe that in the near future, our surgeons can make timely decisions, but surgical robot to operate according to the surgeon's decision.
2015年12月17日星期四
Behentrimonium chloride
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CAS:17301-53-0
Molecular Formula:C25H54ClN
Molecular Weight:404.16g/mol
Description:Behentrimonium chloride, also known as docosyltrimethylammonium chloride or BTAC-228, is an irritating, toxic, and slightly flammable yellow waxlike organic compound with chemical formula CH3(CH2)21N(Cl)(CH3)3 , used as an antistatic agent and a disinfectant. It is commonly found in cosmetics such as conditioners, hair dye, and mousse, and also in detergents. In water treatment, it acts as an algaecide.
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Imidafenacin for sale
Product name:Imidafenacin
CAS:170105-16-5
Molecular Formula:C20H21N3O
Formula Weight:319.4g/mol
Description:Imidafenacin is an antimuscarinic that is used in the treatment of urinary frequency, urgency, and incontinence.It is an antagonist for the muscarinic acetylcholine (ACh) receptor currently under development for the treatment of overactive bladder. Affinities of imidafenacin and other drugs for muscarinic ACh receptor subtypes were investigated by examining inhibitory effects on ACh release in the rat urinary bladder and K+ efflux in the rat salivary gland in functional and binding assays
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CAS:319460-85-0
Molecular Formula:C22H18N4OS
Formula Weight:386.47g/mol
Description:It inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). It has been shown to significantly inhibit growth of breast cancer in xenograft models and has been successful in trials with renal cell carcinoma (RCC) and several other tumor types.
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Product name:Etizolam
CAS:40054-69-1
Molecular Formula:C17H15ClN4S
Molecular Weight:342.8g/mol
Description:Etizolam is a thienodiazepine drug which is a benzodiazepine analog. The etizolam molecule differs from most other benzodiazepines in that the benzene ring has been replaced by a thiophene ring.It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
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Nilotinib
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CAS:641571-10-0
Molecular Formula:C28H22F3N7O
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Description:Nilotinib is also known by its clinical code AMN107, has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib (Gleevec), another tyrosine kinase inhibitor currently used as a first-line treatment.It is a tyrosine kinase inhibitor.
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