Product name:Kratom extract
Description:Kratom is one of the most popular drugs today. It comes from Southeast Asia and the leaves of it have been used in herbal drug.
2016年1月5日星期二
Thomson Reuters 2015 Global DRUG Hall of Fame
The global total of 49 new molecular entities (NME) and biological drugs approved and marketed for the first time. In addition, worldwide, has been listed drugs has 29 major product line extension was approved for the first time, including new indications, new formulations or new Compound; 21 new molecular entities in the world's first approved, but not yet listed.
Although these figures show that runs the pharmaceutical and biotechnology industries as a whole is good, but compared to last year's global listing of 59 new drugs, the number decreased. However, far more important to the quality of quantity, 2015 listing of new drugs, there are some very distinguished members.
Most new cancer drugs for decades
For cancer patients, this is worth celebrating, since 2015 listed over the past decade the number of new cancer drugs most of the year. Overall, the global total of 14 new cancer drugs to market for the first time.
Wherein the multiple myeloma is the most obvious area. In 2015, there are four new drug approved for multiple myeloma and listed. Prior to this, there have been ten years no new drugs for multiple myeloma, and several on the market only a handful of drugs. Chairman of the Multiple Myeloma Research Foundation borrow Walter Capone's words, in 2015, for the United States 90,000 this rare blood cancer patients, is a "watershed."
Although these figures show that runs the pharmaceutical and biotechnology industries as a whole is good, but compared to last year's global listing of 59 new drugs, the number decreased. However, far more important to the quality of quantity, 2015 listing of new drugs, there are some very distinguished members.
Most new cancer drugs for decades
For cancer patients, this is worth celebrating, since 2015 listed over the past decade the number of new cancer drugs most of the year. Overall, the global total of 14 new cancer drugs to market for the first time.
Wherein the multiple myeloma is the most obvious area. In 2015, there are four new drug approved for multiple myeloma and listed. Prior to this, there have been ten years no new drugs for multiple myeloma, and several on the market only a handful of drugs. Chairman of the Multiple Myeloma Research Foundation borrow Walter Capone's words, in 2015, for the United States 90,000 this rare blood cancer patients, is a "watershed."
Vitamin D deficiency is apt to cause stress fractures
"Vitamin D levels can influence the body's calcium and phosphorus in food intake element", the first author of the article, the University of Pennsylvania School of Medicine, Jason R Miller said.
They found that the amount of calcium in patients with insufficient levels of vitamin D intake of only 10% to 15% of the ordinary people, phosphoric acid and intake of 50% -60%. "As a result, inadequate intake of these elements results in a lower degree of mineralization of bone tissue."
However, the authors also pointed out that the degree of vitamin D deficiency in these patients can be predicted to get. "To ensure that fully functional bone health was the lowest 25-hydration serum vitamin D levels still inconclusive." However, "we hope to establish a standard vitamin D content by way of discussion, suggesting that patients risk for stress fractures."
Stress fractures are usually sports injury, when the bone pressure greater than its maximum pressure to withstand stress fracture will occur events. The researchers analyzed data from the period 2011 to 2014, Miller's 124 doctors diagnosed a stress fracture of patients' records, the results showed: serum 53 patients during the 25-month average concentration of vitamin D was 31.1 hydration ng / ml. Where the content is less than 44 patients 40ng / ml, according to the standard vitamin D committee, this value indicates vitamin D deficiency; in addition, there are 28 patients with vitamin D levels less than 30ng / ml.
One-third of patients with second metatarsal stress fracture occurred, 17.6% in the third metatarsal stress fractures occurred.
"Studies have reported the content of 25- hydrated before contacting vitamin D and stress fractures among the lowest they recommended serum levels of vitamin D can not be less than 40ng / mg, especially for the physical activity needs of the larger population." .
They found that the amount of calcium in patients with insufficient levels of vitamin D intake of only 10% to 15% of the ordinary people, phosphoric acid and intake of 50% -60%. "As a result, inadequate intake of these elements results in a lower degree of mineralization of bone tissue."
However, the authors also pointed out that the degree of vitamin D deficiency in these patients can be predicted to get. "To ensure that fully functional bone health was the lowest 25-hydration serum vitamin D levels still inconclusive." However, "we hope to establish a standard vitamin D content by way of discussion, suggesting that patients risk for stress fractures."
Stress fractures are usually sports injury, when the bone pressure greater than its maximum pressure to withstand stress fracture will occur events. The researchers analyzed data from the period 2011 to 2014, Miller's 124 doctors diagnosed a stress fracture of patients' records, the results showed: serum 53 patients during the 25-month average concentration of vitamin D was 31.1 hydration ng / ml. Where the content is less than 44 patients 40ng / ml, according to the standard vitamin D committee, this value indicates vitamin D deficiency; in addition, there are 28 patients with vitamin D levels less than 30ng / ml.
One-third of patients with second metatarsal stress fracture occurred, 17.6% in the third metatarsal stress fractures occurred.
"Studies have reported the content of 25- hydrated before contacting vitamin D and stress fractures among the lowest they recommended serum levels of vitamin D can not be less than 40ng / mg, especially for the physical activity needs of the larger population." .
2016年1月4日星期一
FG-2216
Product name:FG-2216
Description:A new drug called FG-2216 can stimulate production of the hormone erythropoietin (EPO) in dialysis patients—possibly offering a new approach to treatment of kidney disease-related anemia, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).
2016年1月3日星期日
Methylone
Molecular Formula:C11H13NO3
Molecular Weight:207.23g/mol
Description:Methylone, also known as "M1", 3,4-methylenedioxy-N-methylcathinone, bk-MDMA, MDMC, and in the UK as Arlone, is an entactogen and stimulant of the phenethylamine, amphetamine, and cathinone classes.It is a close structural analogue of MDMA, differing by the addition of a β-ketone group.
from:http://www.chemicalspharm.com/New-Products/Methylone-/
Win-35428 origin
First proposed segregation fractionation column (CFT) of Clark and colleagues in 1973. As we all know, the tentacles of this drug to the top played a "positive reinforcement." Is often used tritium CFT new MAP binding ligand DAT although this drug, There are also some SERT affinity.
Concrete filled steel tube formed radiolabeled dopamine transporter medicament for human and animal distribution in brain CFT. The method is particularly suitable for the present application fluoro normal may be substituted widely used radioisotope 18F positron emission tomography other radioisotopes substituted analog won 35,428 carbon atoms (wherein N-methyl, or methyl 2-methyl ester groups from steel concrete, instead of 11C) document is now more commonly used in this application, because it can be faster and more convenient radiolabeled form concepts by methylation CFT get CFTCFT to go to, or 2-methyl-response than methylecgonidineparafluorophenylmagnesium and bromine, and also to avoid the scope of the requirements, including the manufacture, import, sale, retail, restricted precursor and ecgonine.
CFT addictive cocaine in animal studies, but because of how small a manner similar to cocaine longer duration of action, which potentially can turn it into a suitable pharmaceutical alternatives to the use of methadone in place of softwood bleached kraft pulp (opiates in addiction treatment.
from:https://en.wikipedia.org/wiki/WIN_35428
Scientists found that the "ultimate" antibiotic resistance genes
Bacteria worldwide are resistant to colistin there is a - a kind of "ultimate" antibiotic - genes. Related findings from China in November, followed by Denmark, the Netherlands, France and Thailand also found similar resistance genes.
Although this discovery worrying, but they may not like a lot of media coverage that would have disastrous consequences, since only one of several colistin dosage in humans is very rare antibiotics. The discovery "has brought very bad news, but not apocalyptic," American University of Utah, Salt Lake City, Dr. Makoto Jones said infectious disease.
Colistin was developed in the 1950s and is a polymyxin compounds. It has the title of "ultimate" of drugs, doctors will avoid as much as possible the use of this drug, because it can damage the patient's kidneys, University of Washington epidemiologist Lance Price said.
Therefore, compared with other antibiotics, the bacteria difficult to colistin resistance.
In fact, there have been previous reports of colistin-resistant mutations. Many soil bacteria are its resistance, because the drug is widely used in agriculture, long fat pigs, farm animals and prevent illness. In China, the amount of colistin is particularly high, the annual amount of applied agricultural sector reached 12,000 tons.
The latest findings show that colistin resistance gene is present in a loop of DNA called plasmids, and among bacteria already in the "share" of this resistance gene. Chinese researchers found E. coli in a sample of more than one province is called mcr-1 gene, indicating that the gene can spread easily; the same resistance gene have been found in Asia, Europe. Danish researchers have found that E. coli resistance can be passed to other unrelated bacteria.
The researchers said that the emergence of existing antibiotics can not treat bacterial infections but sooner or later. The US Food and Drug Administration in the past two years has approved several new antibiotics, of which there are more than 30 kinds of antibiotics being reviewed. But a lot of antibiotics, similar features and existing drugs, and does not produce better results.
Although this discovery worrying, but they may not like a lot of media coverage that would have disastrous consequences, since only one of several colistin dosage in humans is very rare antibiotics. The discovery "has brought very bad news, but not apocalyptic," American University of Utah, Salt Lake City, Dr. Makoto Jones said infectious disease.
Colistin was developed in the 1950s and is a polymyxin compounds. It has the title of "ultimate" of drugs, doctors will avoid as much as possible the use of this drug, because it can damage the patient's kidneys, University of Washington epidemiologist Lance Price said.
Therefore, compared with other antibiotics, the bacteria difficult to colistin resistance.
In fact, there have been previous reports of colistin-resistant mutations. Many soil bacteria are its resistance, because the drug is widely used in agriculture, long fat pigs, farm animals and prevent illness. In China, the amount of colistin is particularly high, the annual amount of applied agricultural sector reached 12,000 tons.
The latest findings show that colistin resistance gene is present in a loop of DNA called plasmids, and among bacteria already in the "share" of this resistance gene. Chinese researchers found E. coli in a sample of more than one province is called mcr-1 gene, indicating that the gene can spread easily; the same resistance gene have been found in Asia, Europe. Danish researchers have found that E. coli resistance can be passed to other unrelated bacteria.
The researchers said that the emergence of existing antibiotics can not treat bacterial infections but sooner or later. The US Food and Drug Administration in the past two years has approved several new antibiotics, of which there are more than 30 kinds of antibiotics being reviewed. But a lot of antibiotics, similar features and existing drugs, and does not produce better results.
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