A recent study found that fish oil can be stored fat cells into fat-burning cells, which may help curb weight gain in middle-aged. Research results were published in international journals scientific reports.
The researchers explained that fish oil can activate receptors in the digestive tract, activating the sympathetic nervous system, thereby inducing fat cells metabolize fat.
Not all fat tissue to store fat. White fat cells store fat can help maintain energy supply, while brown fat cells are primarily responsible for the metabolism of fat to maintain normal body temperature. Brown fat cells in the baby's body is relatively abundant, but decreased with age, most of adulthood brown fat will disappear.
Another fat cells - beige fat cells - a type of fat cells in humans and mice recently found, studies have shown fat cells beige brown fat cells have a similar function, such cells will increase with age growth reduction, without these burning fat cells, the fat will be piled up for decades and will not be consumed.
In this study, researchers for the intake of a particular type of food is to increase the number of beige fat cells were studied. The authors say: "We know from previous studies in some of the fish oil has many health benefits, including preventing the accumulation of fat, so we are on whether fish oil intake and beige fat increases an association has been studied."
The researchers carried out a group of mice fed the control diet, while another group on the basis of the control diet added fish oil, results showed that compared to the control group did not eat fish oil, fish oil 5% weight loss in mice 10%, fat content decreased by 15% to 25%. The researchers also found that when the sympathetic activation within white adipose tissue will form a new beige fat cells, increased fat consumption.
2015年12月21日星期一
4-Azaindole for sale
Product name:4-Azaindole
CAS:272-49-1
Molecular Formula:C7H6N2
Molecular Weight:118.14g/mol
Description:Off-white Crystalline Powder.Melting point is 116~118°C.High Pressure Liquid Chromatography is ≥98.0%.
Would like to ask specific details, please click here Email:sales@chemicalspharm.com
University of California researchers said type 1 diabetes immunotherapy has great prospects
University of California, San Francisco researchers said on the 25th, a use of the patient's own immune cells immune therapy shows great promise in the treatment of type 1 diabetes in early clinical trials.
The researchers in the new issue of the day the American magazine "Science Translational Medicine" the report said, the use of this therapy in patients with type I diabetes blood regulation of immune cells called T cells, proving the safety of only Phase I clinical trials no serious side effects, and these cells can be present in the patient at least one year.
First author, UCSF professor Jeffrey Blue Stone said in a statement that if this new therapy can prove in further experiments in the protection of human insulin secretory capacity, then it will become "rules of the game-changer."
In Phase I clinical trials, the researchers first extracted from the body type 1 diabetes 2 small cups of blood, and then isolated from 2 million to 4 million of regulatory T cells in laboratory culture after 1500 times their number may increase. Blue Stone said, the activity of regulatory T cells cultured by such a process enhancements, fixes type I diabetics have defective immune responses, and prolonged survival in a patient.
The trial in 14 years to 43 years 18 patients were divided into four groups, receiving a varying number of autologous regulatory T cell injection, which is the minimum number 5000000 regulatory T cells, most are 2.6 billion regulatory T cells. The results showed that all four groups were well tolerated, and up to 25% of the cells over a year but also in the patient is detected.
Based on this result, the researchers are now ready to phase Ⅱ clinical trials to verify the effectiveness of this therapy. Blue Stone said: "The use of the patient's own cells are the new pillars of the drug development process exciting, and we look forward to regulatory T cells in the future become an important part of the treatment of diabetes."
The researchers in the new issue of the day the American magazine "Science Translational Medicine" the report said, the use of this therapy in patients with type I diabetes blood regulation of immune cells called T cells, proving the safety of only Phase I clinical trials no serious side effects, and these cells can be present in the patient at least one year.
First author, UCSF professor Jeffrey Blue Stone said in a statement that if this new therapy can prove in further experiments in the protection of human insulin secretory capacity, then it will become "rules of the game-changer."
In Phase I clinical trials, the researchers first extracted from the body type 1 diabetes 2 small cups of blood, and then isolated from 2 million to 4 million of regulatory T cells in laboratory culture after 1500 times their number may increase. Blue Stone said, the activity of regulatory T cells cultured by such a process enhancements, fixes type I diabetics have defective immune responses, and prolonged survival in a patient.
The trial in 14 years to 43 years 18 patients were divided into four groups, receiving a varying number of autologous regulatory T cell injection, which is the minimum number 5000000 regulatory T cells, most are 2.6 billion regulatory T cells. The results showed that all four groups were well tolerated, and up to 25% of the cells over a year but also in the patient is detected.
Based on this result, the researchers are now ready to phase Ⅱ clinical trials to verify the effectiveness of this therapy. Blue Stone said: "The use of the patient's own cells are the new pillars of the drug development process exciting, and we look forward to regulatory T cells in the future become an important part of the treatment of diabetes."
ETIZOLAM distinction where
Etizolam is a drug that is chemically similar to benzodiazepines and legal requirement in Japan, Italy and India. Sold under brand names including Depas, Etizest, Etizola, Sedekopan, Etilaam and Pasaden on the black market in the US and Europe, it is a potent drug and is also very addictive.
In countries where it is legal for use, etizolam is prescribed for treatment of insomnia and anxiety, similar to benzodiazepines (such as Xanax, Ativan, Valium) are here. Unfortunately, when the drug is used or misused without prescription, the result of an overdose, addiction and / or death can. Also, if etizolam combined with the use of alcohol, significantly increase these risks and the risk of accidents and other serious medical emergencies.
Etizolam
Etizolam currently not included in the Controlled Substances Act, but early research indicates that it is a very effective substance -. As much as 6-10 times as potent as diazepam (Valium for example) in clinical trials In addition, there were a number of "adverse effects" in the mode has also been reported, including:
Muscle weakness
Lack of coordination
Comfort
Unconsciousness
Headache
Drowsiness
Confusion
Slurred speech
Blurred vision
Changes in libido
Depression
Tremor or trembling
Because etizolam is not approved for medical use in the United States, any use of the drug is designated in this abuse of the country.
Alcohol
Although alcohol is readily available and most people in the US drink socially, alcohol is a poison and can have a strong impact on the body and the brain - both acute when the person under the influence and long-term regular use per year.
According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), alcohol has the following effects on the brain and body:
Alcohol interferes with the functioning of the brain, which in turn disrupts the ability of mood, behavior and coordination of the person to manage.
Fast or irregular heartbeat and high blood pressure are common when someone is drinking.
Alcohol has a negative effect on the liver and pancreas, especially if the beverage drinkers (eg, more than four drinks in one drinking session for women and more than five drinks in one drinking session for men) .
Alcohol consumption may reduce the immune system of the drinker himself vulnerable to making all kinds of diseases.
Even in small amounts, alcohol can person's ability to drive a vehicle behavior, think clearly and reduce manage.
The synergistic effect
When a person takes a drug which is combined and an effect similar to benzodiazepines (eg, etizolam) that drugs with alcohol, the effect is synergistic. In other words, the effect in the body when the substances to be combined is greater than the sum of the effects of the two, when taken separately. This means that someone has just a drink or two with a low dose of etizolam and overwhelmed; side effects both can be severe. Overdose, accident and life change bad decisions were made under the influence of a lot sooner if someone mixes all addictive prescription drugs with alcohol.
Treatment of drug abuse Poly
If someone you love has a drinking problem and combining with the use of other drugs - drugs like routine etizolam - treatment can help stop drinking and stop the use of all other substances of abuse. Learn more about how to ensure drinking high off your love today and always. Call now the future.
In countries where it is legal for use, etizolam is prescribed for treatment of insomnia and anxiety, similar to benzodiazepines (such as Xanax, Ativan, Valium) are here. Unfortunately, when the drug is used or misused without prescription, the result of an overdose, addiction and / or death can. Also, if etizolam combined with the use of alcohol, significantly increase these risks and the risk of accidents and other serious medical emergencies.
Etizolam
Etizolam currently not included in the Controlled Substances Act, but early research indicates that it is a very effective substance -. As much as 6-10 times as potent as diazepam (Valium for example) in clinical trials In addition, there were a number of "adverse effects" in the mode has also been reported, including:
Muscle weakness
Lack of coordination
Comfort
Unconsciousness
Headache
Drowsiness
Confusion
Slurred speech
Blurred vision
Changes in libido
Depression
Tremor or trembling
Because etizolam is not approved for medical use in the United States, any use of the drug is designated in this abuse of the country.
Alcohol
Although alcohol is readily available and most people in the US drink socially, alcohol is a poison and can have a strong impact on the body and the brain - both acute when the person under the influence and long-term regular use per year.
According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), alcohol has the following effects on the brain and body:
Alcohol interferes with the functioning of the brain, which in turn disrupts the ability of mood, behavior and coordination of the person to manage.
Fast or irregular heartbeat and high blood pressure are common when someone is drinking.
Alcohol has a negative effect on the liver and pancreas, especially if the beverage drinkers (eg, more than four drinks in one drinking session for women and more than five drinks in one drinking session for men) .
Alcohol consumption may reduce the immune system of the drinker himself vulnerable to making all kinds of diseases.
Even in small amounts, alcohol can person's ability to drive a vehicle behavior, think clearly and reduce manage.
The synergistic effect
When a person takes a drug which is combined and an effect similar to benzodiazepines (eg, etizolam) that drugs with alcohol, the effect is synergistic. In other words, the effect in the body when the substances to be combined is greater than the sum of the effects of the two, when taken separately. This means that someone has just a drink or two with a low dose of etizolam and overwhelmed; side effects both can be severe. Overdose, accident and life change bad decisions were made under the influence of a lot sooner if someone mixes all addictive prescription drugs with alcohol.
Treatment of drug abuse Poly
If someone you love has a drinking problem and combining with the use of other drugs - drugs like routine etizolam - treatment can help stop drinking and stop the use of all other substances of abuse. Learn more about how to ensure drinking high off your love today and always. Call now the future.
2015年12月20日星期日
$ 4,000,000,000! AstraZeneca announced the acquisition of Acerta 55% stake in the pharmaceutical
AstraZeneca will spread industry had $ 5 billion takeover rumors finally sit Acerta real difference is that the actual offer AstraZeneca is $ 4 billion, the acquisition of 55% stake Acerta. Acerta is a little-known biotechnology company, there were no drugs to the market, the main development of cancer and autoimmune related drugs. Acerta Currently in development of BTK inhibitors acalabrutinib has been granted FDA Orphan Drug treatment of mantle cell lymphoma qualify for a public analysts are optimistic.
Under the agreement, AstraZeneca will pay Acerta 25 亿 美元 advances, then approved by the FDA on or before the end of 2018, and then unconditionally pay $ 1.5 billion in acalabrutinib.
Under the agreement, AstraZeneca received only 55% of the shares Acerta, but AstraZeneca can still purchase the remaining 45% stake in the company by Acerta shareholders. AstraZeneca full acquisition Acerta specific time can not be determined, depending on acalabrutinib simultaneously approved in the US and Europe time. Once ripe, AstraZeneca intends to pay $ 3 billion net to acquire the remaining 45% stake.
Observe the agreement, not difficult to find acalabrutinib completely awful merger achievement core drugs. Currently acalabrutinib are all kinds of leukemia, lymphoma clinical trials, but also with Merck's tumor immune drugs Keytruda (pembrolizumab) carried out a joint drug test. Acalabrutinib BTK inhibitors are a class with Abbvie / Johnson leukemia drugs Imbruvica (ibrutinib) mechanism of action is similar, is generally considered peak sales will be more than 5 billion US dollars.
Early clinical data results Acalabrutinib also gratifying. Recently published in the New England Journal of Medicine Phase I / II clinical trial results showed that the response rate in patients with chronic lymphocytic leukemia drug has reached 95%, while adult leukemia, chronic lymphocytic leukemia is the most common one.
Under the agreement, AstraZeneca will pay Acerta 25 亿 美元 advances, then approved by the FDA on or before the end of 2018, and then unconditionally pay $ 1.5 billion in acalabrutinib.
Under the agreement, AstraZeneca received only 55% of the shares Acerta, but AstraZeneca can still purchase the remaining 45% stake in the company by Acerta shareholders. AstraZeneca full acquisition Acerta specific time can not be determined, depending on acalabrutinib simultaneously approved in the US and Europe time. Once ripe, AstraZeneca intends to pay $ 3 billion net to acquire the remaining 45% stake.
Observe the agreement, not difficult to find acalabrutinib completely awful merger achievement core drugs. Currently acalabrutinib are all kinds of leukemia, lymphoma clinical trials, but also with Merck's tumor immune drugs Keytruda (pembrolizumab) carried out a joint drug test. Acalabrutinib BTK inhibitors are a class with Abbvie / Johnson leukemia drugs Imbruvica (ibrutinib) mechanism of action is similar, is generally considered peak sales will be more than 5 billion US dollars.
Early clinical data results Acalabrutinib also gratifying. Recently published in the New England Journal of Medicine Phase I / II clinical trial results showed that the response rate in patients with chronic lymphocytic leukemia drug has reached 95%, while adult leukemia, chronic lymphocytic leukemia is the most common one.
2015 shook the man who is the biomedical sector?
Tu Yo Yo: 2015 Chinese scientific community most dazzling names, to achieve a breakthrough Chinese scientists the Nobel Prize. She makes the world more people feel the charm of traditional Chinese medicine.
September 2011, the discovery of artemisinin - a drug used to treat malaria, saving millions of lives the world, particularly in developing countries, Tu Yo Yo obtain a Nobel benchmark known Lasker Award . In June 2015, Tu Yo Yo was awarded the Warren Albert Award from Harvard University. October 2015, the Nobel Committee announced that China pharmacists Tu Yo Yo obtain fiscal 2015 Nobel Prize in Physiology or Medicine.
Perseverance, perseverance is committed to antimalarial drug research, discovery of artemisinin antimalarial international made important contributions. In Tu Yo Yo who embodies the Chinese scientists noble feelings and tirelessly for the people of science stick.
September 2011, the discovery of artemisinin - a drug used to treat malaria, saving millions of lives the world, particularly in developing countries, Tu Yo Yo obtain a Nobel benchmark known Lasker Award . In June 2015, Tu Yo Yo was awarded the Warren Albert Award from Harvard University. October 2015, the Nobel Committee announced that China pharmacists Tu Yo Yo obtain fiscal 2015 Nobel Prize in Physiology or Medicine.
Perseverance, perseverance is committed to antimalarial drug research, discovery of artemisinin antimalarial international made important contributions. In Tu Yo Yo who embodies the Chinese scientists noble feelings and tirelessly for the people of science stick.
Yo Yo Tu Artemisinin of Artesunate
Artemisinin can be used alone, but it has been very high and other reasons leading to relapse (return) and other parasites varieties of drugs, people must remove all parasites, as well as to prevent similar incidents from happening again. World Health Organization (WHO) forces manufacturers will stop making the drug available for non-complex medical community attributes, Mara artemisinin resistant malaria parasites RIA aware of disaster situation was under development.
Who recommends artemisinin combination therapy (action) in the treatment of first-line drugs falciparum malaria. Artemisinin combination of ingredients because the parasite will kill most effective treatment, while the remaining pair to clear the slower clearance of the drug at the beginning of parasites.
Inotropic agents and partners a very long half-life of several behavior is now available fixed-dose artemisinin-containing composition is highly selective, such as mefloquine abnormal black Munziq, lumefantrine (Coartem ), amodiaquine (pulp), piperaquine high-tech drugs "Ketai new" (double), and Pyronaridine Pyramax (). Increasingly, these combinations, so make the GMP standard. A separate issue, relations to education, the quality of teaching is good or bad some of artemisinin-containing products are exported to Africa and Southeast Asia.
Product name:Artesunate
CAS: 88495-63-0
Molecular Formula:C19H28O8
Formula Weight: 384.42
Description:
Artesunate (INN) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS.
Artesunate is used primarily as treatment for malaria; but it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection
Would like to ask specific details, please click here Email:sales@acridine-raw-material.com
Who recommends artemisinin combination therapy (action) in the treatment of first-line drugs falciparum malaria. Artemisinin combination of ingredients because the parasite will kill most effective treatment, while the remaining pair to clear the slower clearance of the drug at the beginning of parasites.
Inotropic agents and partners a very long half-life of several behavior is now available fixed-dose artemisinin-containing composition is highly selective, such as mefloquine abnormal black Munziq, lumefantrine (Coartem ), amodiaquine (pulp), piperaquine high-tech drugs "Ketai new" (double), and Pyronaridine Pyramax (). Increasingly, these combinations, so make the GMP standard. A separate issue, relations to education, the quality of teaching is good or bad some of artemisinin-containing products are exported to Africa and Southeast Asia.
Product name:Artesunate
CAS: 88495-63-0
Molecular Formula:C19H28O8
Formula Weight: 384.42
Description:
Artesunate (INN) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS.
Artesunate is used primarily as treatment for malaria; but it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection
Would like to ask specific details, please click here Email:sales@acridine-raw-material.com
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