After experiencing a heart attack or other heart trauma, heart can not effectively remove heart cell death, while heart transplantation transplant patients in addition to the treatment of choice almost rarely, a heart transplant is not very easy, recently researchers using cell The therapy of heart cells after transplantation into the damaged heart patients, but in most cases these cells were transplanted into the heart will not be good for growth after implantation, so that the possibility of the patient's heart will eventually recover greatly reduced.
One reason for the occurrence of migration issues is the quality of heart cells, in a typical cell therapy, cardiac cells usually come from different stem cells, but the quality of cardiac cells but it will not stop change; in particular, the process of maturation of heart cells is is not the same, but different mature cells are also used for transplant are mixed together; researchers from Kyoto University in Japan Shunsuke Funakoshi has carried out a new study to investigate heart cells for transplantation best maturation process, thus it for the successful development of effective cell therapy of heart problems provide some clues and ideas.
Under the guidance of the researcher Yoshinori Yoshida, Funakoshi skin cells to induce reprogramming of the formation from the pluripotent stem cells (iPS) operates to convert it into heart cells, and the differentiation of cardiac iPS cells can be efficiently through all developmental stage. The researchers said that the different stages of heart cells tend behavior is not the same, so we prepared a different maturity stages of heart cells and transplanted into the damaged hearts of mice in vivo, so 20 days to accept the mature heart cells by Loss of heart will preferably receive transplanted into heart cells, and this time is longer or shorter than the mature cardiac cells implanted is much better, which indicates a successful cell therapy to optimal cardiac cells mature stage is critical; the same researchers also said that transplant patients for different times and can not be determined by this study.
Currently undergoing human heart cell therapy takes about one billion cells, which cells specifically suited for the treatment can not only help improve the treatment and prognosis of patients, but also reduce the number of the cells need this for the future to effectively reduce unnecessary waste and the procedure brought some help and hope.
2016年1月11日星期一
Successful pregnancy may only need three genes on the male Y chromosome
Published in the international journal PLoS Genetics of a research report, researchers from the University of Hawaii Institute of biological origin by studying the Y chromosome genes uncovered the body of the new features; article by the researchers found that male mice only need 3 genes from the Y chromosome sperm can be manufactured, through microinjection (intracytoplasmic sperm injection, ICSI) with the egg after fertilization, and produce offspring.
Two years ago, the research team successfully obtained only male mice of the body 2 Y chromosome gene bred offspring of these two genes, called testis determining child Sry and spermatogonial proliferation factor Eif2s3y, these male mice do not produce sperm to completion of the fertilization process, the researchers had to use the body of mice immature precursor cells - sperm cells and a cytoplasmic sperm injection, called a spherical (round spermatid injections, ROSI) to study. The researchers believe that this technology called ROSI is an experimental step, but it has not been recommended as a treatment for male infertility treatments, but ICSI was widely used in the world, the use of ICSI technique bred tens annually million newborns.
Researchers believe that gene Y chromosome probably mainly responsible for the sperm cells into sperm; and with the results of a joint study from France, Britain and other multinational research staff, researchers hypothesize that a key gene on the Y chromosome may be Zfy2 ( encoding a zinc finger protein 2), then they will Zfy2 added to by transgenic methods already exist but Sry and Eif2s3y transgenic male mice deletion of the Y chromosome in the body, results showed that the three mouse Y chromosome carries genes will produce sperm, these male mice were not able to produce their own sperm, because of its low sperm levels. But when the researchers harvested sperm by the testes of mice which were injected into the egg can be a successful pregnancy, the embryo into a surrogate female mouse body after birth rate of young mice, as compared to the control group in terms of (carrying the normal Y mouse chromosomes).
Researchers Ward noted that the three Y chromosome-derived gene may be enough to help the body to produce functional sperm and then promote fertilization, ICSI technique is often used in human infertility therapy, this study found that the round sperm cells into sperm It is a critical process, but perhaps mediated gene Zfy2 an important regulator of the process, including sperm maturation and function of play.
Two years ago, the research team successfully obtained only male mice of the body 2 Y chromosome gene bred offspring of these two genes, called testis determining child Sry and spermatogonial proliferation factor Eif2s3y, these male mice do not produce sperm to completion of the fertilization process, the researchers had to use the body of mice immature precursor cells - sperm cells and a cytoplasmic sperm injection, called a spherical (round spermatid injections, ROSI) to study. The researchers believe that this technology called ROSI is an experimental step, but it has not been recommended as a treatment for male infertility treatments, but ICSI was widely used in the world, the use of ICSI technique bred tens annually million newborns.
Researchers believe that gene Y chromosome probably mainly responsible for the sperm cells into sperm; and with the results of a joint study from France, Britain and other multinational research staff, researchers hypothesize that a key gene on the Y chromosome may be Zfy2 ( encoding a zinc finger protein 2), then they will Zfy2 added to by transgenic methods already exist but Sry and Eif2s3y transgenic male mice deletion of the Y chromosome in the body, results showed that the three mouse Y chromosome carries genes will produce sperm, these male mice were not able to produce their own sperm, because of its low sperm levels. But when the researchers harvested sperm by the testes of mice which were injected into the egg can be a successful pregnancy, the embryo into a surrogate female mouse body after birth rate of young mice, as compared to the control group in terms of (carrying the normal Y mouse chromosomes).
Researchers Ward noted that the three Y chromosome-derived gene may be enough to help the body to produce functional sperm and then promote fertilization, ICSI technique is often used in human infertility therapy, this study found that the round sperm cells into sperm It is a critical process, but perhaps mediated gene Zfy2 an important regulator of the process, including sperm maturation and function of play.
Lappaconitine Hydrobromide
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CAS:97792-45-5
Molecular Weight:665.61g/mol
Molecular Formula:C32H45BrN2O8
Description:Production of lappaconitine hydrobromide is required for the clinical use of an effective domestic medicinal drug for preventing and treating cardiovacsular pathologies.It is implemented at the Experimental Chemical Production of the Vorozhtsov Novosibirsk Institute of Organic Chemistry (NIOC), SB RAS.
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Alkyl dimethyl benzyl ammonium chloride
Product name:Alkyl dimethyl benzyl ammonium chloride
CAS:8001-54-5
Molecular Formula:C17H30ClN
Molecular Weight:283.88g/mol
Description:Benzalkonium chloride, also known as alkyldimethylbenzylammonium chloride and ADBAC, is a mixture of alkylbenzyldimethylammonium chlorides of various even-numbered alkyl chain lengths. This product is a nitrogenous cationic surface-acting agent belonging to the quaternary ammonium group. It has three main categories of use; as a biocide, a cationic surfactant and phase transfer agent in the chemical industry.
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Product name:HCG Pharmaceutical
Description:HCG (Human Chorionic Gonadotropin) has become a preferred treatment for obesity and weight loss by physicians around the world. What is the reasoning behind this? In combination with a low calorie diet, HCG is believed to help safely speed up weight loss by slightly raising hormone levels in the body, such as estrogen, progesterone and testosterone.
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Potassium Sodium Hydrogen Citrate Granules
Product name:Potassium Sodium Hydrogen Citrate Granules
Description:Potassium Sodium Hydrogen Citrate Granules is used to dissolve uric acid calculi in the urinary tract and to prevent further stone formation
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Tinogard HS for sale
Product name:Tinogard HS
Description: Sodium Benzotriazole Butyl Phenol Sulfonate is an anionic photostabilizer but is also an effective UVA/UVB absorber.
Applications: Cleaners, protectants, polishes, waxes and other surface care products for both the I&I and consumer household industries.
Comments: Tinogard HS helps to protect different types of surfaces, such as wood, leather and others from the adverse affects of ultraviolet light, thereby keeping surfaces looking like new for longer. It works by absorbing both UVA and UVB light. Tinogard HS is supplied as a powder and is for use in water- or alcohol-based formulations.
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