The scientists used skin cells to successfully treat heart damage

After experiencing a heart attack or other heart trauma, heart can not effectively remove heart cell death, while heart transplantation transplant patients in addition to the treatment of choice almost rarely, a heart transplant is not very easy, recently researchers using cell The therapy of heart cells after transplantation into the damaged heart patients, but in most cases these cells were transplanted into the heart will not be good for growth after implantation, so that the possibility of the patient's heart will eventually recover greatly reduced.

One reason for the occurrence of migration issues is the quality of heart cells, in a typical cell therapy, cardiac cells usually come from different stem cells, but the quality of cardiac cells but it will not stop change; in particular, the process of maturation of heart cells is is not the same, but different mature cells are also used for transplant are mixed together; researchers from Kyoto University in Japan Shunsuke Funakoshi has carried out a new study to investigate heart cells for transplantation best maturation process, thus it for the successful development of effective cell therapy of heart problems provide some clues and ideas.

Under the guidance of the researcher Yoshinori Yoshida, Funakoshi skin cells to induce reprogramming of the formation from the pluripotent stem cells (iPS) operates to convert it into heart cells, and the differentiation of cardiac iPS cells can be efficiently through all developmental stage. The researchers said that the different stages of heart cells tend behavior is not the same, so we prepared a different maturity stages of heart cells and transplanted into the damaged hearts of mice in vivo, so 20 days to accept the mature heart cells by Loss of heart will preferably receive transplanted into heart cells, and this time is longer or shorter than the mature cardiac cells implanted is much better, which indicates a successful cell therapy to optimal cardiac cells mature stage is critical; the same researchers also said that transplant patients for different times and can not be determined by this study.

Currently undergoing human heart cell therapy takes about one billion cells, which cells specifically suited for the treatment can not only help improve the treatment and prognosis of patients, but also reduce the number of the cells need this for the future to effectively reduce unnecessary waste and the procedure brought some help and hope.