What is Securinine alkaloids

There had been experiments to determine the site of action of securinine and related spasmodic Indolizidinen. All these compounds induced tonic induced in mice with CD50 values ​​of 11 to 87 mg / kg. The CD50 for bicuculline was at 8 mg / kg found. Equilibrium binding assays have shown that dihydrosecurinin securinin and [3H] GABA binding to rat brain membranes with an inhibitory IC of about 50 μM, which is about 7-fold less potent than Bicuculline. Allosecurinin Virosecurinin and have IC50 values ​​greater than 1 mM. Both dihydrosecurinin and securinin inhibited GABA-stimulated Benzodiazepinbindung in rat brain membranes, although they were a little weaker in this regard than bicuculline. Other binding assays have shown that securinin and its analogs are inactive as inhibitors of bicuculline insensitive to GABA binding, a benzodiazepine, and the cholinergic receptor beta-adrenergic binding Muskarinin. In addition, while thiocyanate apparent bicuculline cohesion increased by 10-fold, it had little effect on the securinin. Extracellular electrophysiological studies on neurons in the spinal cord of the cat showed that securinin dihydrosecurinin and the inhibitory effect of GABA blocked, without this affected the action of glycine. Allografts and Virosecurinin were significantly less active in this assay than GABA receptor antagonists. These results suggest that, as bicuculline and securinine dihydrosecurinin are selective antagonists of GABA recognition sites in central mammalian neurons.

Epichlorohydrin price

Product name: (S)-(+)-Epichlorohydrin

CAS:67843-74-7

Molecular Formula:C3H5ClO

Molecular Weight:92.52g/mol

Description:Colorless to light yellow liquid.Melting point is ?57 °C(lit.).Boiling point is 92-93 °C360 mm Hg(lit.).Density is 1.183 g/mL at 25 °C(lit.).Refractive index is n20/D 1.438(lit.).

Jurkat, Clone E6-1

Product name:Jurkat, Clone E6-1
Species:Human

Source:T lymphocytes; acute T-cell leukemia

Morphology:Lymphoblast

Medium and additives:
Containing 2mM L-glutamine, 10mM HEPES, 1mM sodium pyruvate, 4.5g/L glucose, 1.5g/L sodium bicarbonate in RPMI medium, 90%; 10% fetal calf serum.

Application:Only for research purposes

Product description:
This is a clone from the Jurkat-FHCRC cell line. Jurkat cell lines derived from peripheral blood of a 14-year-old boy.

What is topical acyclovir?

Acyclovir topically (for the skin) is an antiviral drug. It slows down the growth and spread of the herpes virus, so the body can fight the infection.

Acyclovir topical cream is used to treat cold sores.

Acyclovir ointment is used to treat genital herpes lesions.

Acyclovir will not cure or prevent herpes, but it can reduce the symptoms of the infection.

Topical acyclovir can also be used for purposes that do not result in this product.

What is the most important information I should know about topical acyclovir?
Follow all instructions on the label of the drug and packaging. Tell all of your health care provider about all your medical conditions, allergies and medications you are using.

To ensure that acyclovir is locally safe for you, tell your doctor if you:

Weakness of the immune system (caused by illness or by the use of certain drugs).
FDA pregnancy category B. Topical acyclovir should not harm an unborn baby. Let us know if you are pregnant or plan your doctor during the treatment to get pregnant. The herpes virus can be transmitted from an infected mother to her baby during childbirth. If you have genital herpes, it is very important to prevent herpes lesions during your pregnancy so that you do not have a genital lesion when your baby is born.

It is not known whether topical acyclovir passes into breast milk or whether it could harm the baby. Let us know if you are breastfeeding a baby are your doctor. You should not breastfeed if you have a herpes lesion on or near your chest.

Acyclovir should not be used in children younger than 12 years.

Beta-methyl vinyl phosphate price

Product name: Beta-methyl vinyl phosphate (MAP)
CAS no.: 90776-59-3
Molecular Formula: C29H27N2O10P
Molecular Weight: 594.51
Product description: Penem intermediate.

Epothilone D affects cell cycle

Epothilones, macrocyclic lactones from the culture of Sorangium cellulosum Myxobacteriums are designated in human medicine as taxol-like microtubule drugs. To date, nothing is known about the effect of epothilones on known microtubules (MT) in plant cells and / or on the cell cycle of the plant. As shown in this report, processing tomatoes cell cultures in suspension with epothilone D to a continuous increase in the mitotic index. Dose-response curves have shown that epothilone D alters the mitotic index in concentrations as low as 1.5 MikroM. Mitochondrial arrest was observed after treatment only 2 hours and 55% of the cells were discontinued after 24 hours. As shown by immunozytologic methods occur during metaphase abnormal spindles, which leads to a random distribution of chromosomes throughout the cell and prevent the formation of a metaphase plate. The chromosomal de-condensation process does not appear to be affected, since the formation of micronuclei in the same place with the distributed chromosomes. This suggests that the stability of epothilone D influenced plant MTs mainly during the metaphase of a mitotic cycle. In metaphase, the effects of epothilone D appear to be irreversible, as cells with an abnormal pin could not be recovered after drug elimination.

Epothilone D for sale

Product: epothilones D
CAS: 189453-10 & ndash; 9
Molecular Formula: C27H41NO5S
Appearance: colorless powder
Purity: 99%
Storage: Avoid sunlight, keep dry
Product Description: Epothilone D is a natural Polyketidverbindung that has been isolated from cellulosum myxobacterium Sorangium. Also known as deoxyepothilone B known epothilone D binds to tubulin and prevents disassembly of microtubules, leading to inhibition of mitosis, cell proliferation and cellular motility.