What is Anti D immunoglobulin

Product Name: anti-D immunoglobulin
Description: Immunoglobulin anti-D is used for the prevention of Rh disease (also Rhesus disease, hemolytic disease of the newborn (SHNN) or hemolytic disease of the newborn). Rh disease occurs when a Rh negative mother has given birth to a positive rhesus baby, and then with another Rh positive child becomes pregnant.

Sucrose

Product Name: Sucrose
CAS RN: 57-50-1
Molecular formula: C12H22O11
Molecular Weight: 342
Product Description: The main products of photosynthesis, which are widely used in plants, especially in the very high levels of sugar beet, sugar cane and fruit. Storage facility sucrose, the main form of sugar accumulation and transportation. Normally eat sugar, brown sugar is sugar.

What is Pristimerin

Lack of effective therapeutics for pancreatic cancer at the present time underscores the dire need for safe and effective agents for the treatment of this malignancy. In the present study, we have evaluated the anticancer activity and the mechanism of action of pristimerin (PM), a quinonemethide triterpenoid, against MiaPaCa-2 and Panc-1 pancreatic ductal adenocarcinoma (PDA) cell lines. Treatment with PM inhibited the proliferation and induced apoptosis in both cell lines as characterized by the increased Annexin V-binding and cleavage of PARP-1 and procaspases -3, -8 and -9. PM also induced mitochondrial depolarization and the release of cytochrome c from the mitochondria. The induction of apoptosis by PM was associated with the inhibition of the pro-survival Akt, NF-κB and mTOR signaling proteins and their downstream intermediaries such as Foxo-3α and cyclin D1 (Akt); Cox-2 and VEGF (NF-κB); p-S6K1 and p-4E-BP1 (mTOR) as well as PKCε. Treatment with PM also inhibited the expression of anti-apoptotic Bcl-2 and survivin but not Bcl-xL. The downregulation of Bcl-2 by PM was not due to proteasomal or lysosomal proteolytic degradation of Bcl-2, since treatment with PM in the presence of proteasomal inhibitors MG132 or lactacystin (LAC) or calpain inhibitor MG101 failed to block the downregulation of Bcl-2 by PM. On the other hand, RT-PCR analysis showed the inhibition of Bcl-2 mRNA by PM in a dose-related manner, indicating that inhibition of Bcl-2 by PM is mediated through the suppression of Bcl-2 gene expression. Thus, the mechanistic understanding of the antitumor activity of pristimerin could facilitate in vivo efficacy studies of pristimerin for pancreatic cancer.

Cyclopamine decreased early embryonic development

Hedgehog path (Hh) has been studied in various life processes of the body of the animal and is proposed to be important for the development of several organs. The genes involved in the HH pathway were expressed in the ovary of mice, pigs and bovines. However, the function of the HH signaling pathway for oocyte maturation and early embryonic development is still controversial. We demonstrated the effect of Sonic hedgehog (Shh) and cyclopamine on the in vitro maturation of Mausozyten and the development of the embryo. The results showed that the presence of Shh resulted in cyclopamine oocyte maturation or similar to a control group. Shh not improved early embryonic development. However, the addition of depressed cyclopamine from early embryonic development. The shh, PTCH1, SMO and GLI1 mRNA was less detected in the bare oocytes. Expression levels of PTCH1 increased from the cleaved zygote to Blastozystenstufe. Smo or GLI1 were expressed in early embryonic separately at a higher level in the cell or four cell stages. Therefore Shh influenced the maturation of mouse oocytes and early embryonic development did not, however, cyclopamine resulted in inhibition of the early embryo development of the mouse. The effects of HH signaling in oocyte maturation and early embryonic development may be species specific.

Fangchinoline

Radix Step Haniae Tetrandrae containing tetranin (Tet) and Fangchinoline, is traditionally used as an analgesic, anti-rheumatic drug and anti-hypertensive in China. In this study, we studied its effect on the proliferation of breast cancer cells and their possible mechanism of action in vitro. Treatment of the cells with Fangchinoline inhibited MDA-MB-231 proliferation significantly and concentration-dependent and time-dependent. In order to determine the mechanism underlying the anti-proliferative effects of Fangchinoline, we studied its effect on critical molecular events, one of which is known to regulate apoptotic mechanisms. Specifically, we have the possibility of Fangchinoline to induce apoptosis of breast cancer cells. Fangchinoline interucleosomal DNA-induced fragmentation, chromatin condensation, activation of caspases-3, -8 and (ADP-ribose) polymerase -9 and cleavage of poly and enhanced release of cytochrome c Mitochondrial. In addition Fangchinoline increased expression of the pro-apoptotic protein of B-cell lymphoma associated with X-2 (BAX) and decreased expression of B-cell anti-apoptotic lymphoma protein (Bcl-2). In addition, the anti-proliferative effect of Fangchinoline with reduced amounts was associated with phosphorylated Akt. Our results show that Fangchinoline can inhibit the proliferation of breast cancer cells by inducing apoptosis via the mitochondrial apoptotic pathway and the decrease of phosphorylated Akt. Thus Fangchinoline can be a new way, which can be potentially developed clinically to achieve human malignant tumors.

Fangchinoline price

Product Name: Fangchinoline

CAS Number: 33889-68-8

Molecular Weight: 608.72 g / mol

Molecular formula: C37H40N2O6

Description: Fangchinolin inhibits the proliferation of vascular smooth muscle rat aorta cells, and progression of the cell cycle by inhibition of activation of ERK1 2 / and c-fos expression. It is an active component of Radix Stephania tetrandrinea which has neuroprotective properties.

Cyclovirobuxine A

Product Description: Cyclovirobuxine A

CAS: 808 & ndash; 94-6

Molecular formula: C28H50N2O

Description Cyclovirobuxin A was obtained from the N-methylation end of natural origin Cyclovirobuxin D. It has a four-membered Triterpenoidkern ring in trans-cis-trans configuration. The six-membered rings are Stuhlkonformationen, while the conformation of the five-membered ring is a shell.