What is Deer antler extract

It has been reported that deer extract anti-bone resorption activity in vivo has. However, little is known about the cellular and molecular mechanism of this effect. In this study, we studied the effects of deer antler extracts on osteoclast differentiation and bone resorption in vitro. Chloroform extract (EC-C) of deer inhibits differentiation of osteoclasts in mouse bone marrow cultures that have been stimulated by the NF-kB ligand activator receptor (RANKL), and macrophage colony stimulating factor -CSF). EC C suppressed activation of signal-regulated extracellular kinase (ERK), protein kinase B (PKB / Akt) and kappa inhibitor B (I-kB) by RANKL in osteoclast precursor cells. It also inhibits bone resorption activity of differentiated osteoclasts, which has been accompanied by a disturbance of Aktinringe and induction of apoptosis. These results show, Cerf extract can be a useful remedy in the treatment of bone resorption diseases such as osteoporosis.