Sipeimine price

Product name: Sipeimine
CAS: 61825-98-7
Appearance: White Crystal Powder
Application: All our products are for research and lab only. Injecting, eating and other ways are forbidden.
Purity: ≥98%
Molecular Formula: C27H43NO3
Molecular Weight: 429.62
Description: Easily soluble in chloroform, ethyl acetate, soluble in methanol, alcohol, acetone, diethyl ether, insoluble in water and petroleum ether. Spasmolysis.
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Akebia saponin D for sale

CAS: 39524-08-8
Appearance: Needle crystal powder
Application: All our products are for research and lab only. Injecting, eating and other ways are forbidden.
Purity: >95% or 98% by HPLC
Molecular Formula: C47H76O18
Molecular Weight: 929.10
Description: 1g soluble in 87ml water, 3ml boiling water, 6ml alcohol, 100ml diethyl ether, 10ml glycerinum and 5ml acetone. Mostly insoluble in benzene, chloroform and petroleum ether. Hemostasis, promote healing of bone lesions, lower uterine contractions, nourishing liver and kiney.

from:http://www.chemicalspharm.com/products/Pharmaceutical-Intermediates/Akebia-saponin-D/

New discoveries or help develop a malaria vaccine

Scientists from the University of Oxford, etc., perhaps to find a new way to target the malaria parasite; now the impact of malaria each year with more than 40 million lives, and most patients are Plasmodium falciparum (Plasmodium falciparum) caused by infection, but life In the area of ​​malaria outbreaks often people will get a special natural state of immunity to help the body resist malaria infection in adulthood, so the discovery of the possibility of a vaccine against malaria means is from the molecular level up to reveal the body's natural immune these special groups reaction process.

When P. falciparum infection and the body hidden in the red blood cells will lead to serious cause of malaria deaths occur, after many studies have shown that the main component of the body's protective immune response against the surface antigen can be directly called variant , while Plasmodium can use this particular antigen inserted into the surface of the infected red blood cells, usually falciparum will use these molecules to control the infected cell so that it can be adhered to the inner wall of the blood vessel supply of organs, if a large number of Plasmodium infection RBC accumulation will lead to the occurrence of cerebral malaria in the brain.

Under normal circumstances falciparum can produce a variety of different variations of manufacturing surface antigen family, the process although these antigenic molecules naturally acquired immunity in malaria incidence and serious plays an important role, and it usually is because it has diversity I do not think the appropriate candidate vaccines; however Looking for specific antibodies to react with the surface antigen of Plasmodium falciparum variant seems to be able to help develop new interventions against malaria.

The researchers noted that this variant surface antigens include PfEMP1, RIFINs and STEVOR molecules, the researchers had focused on the PfEMP1 molecule research studies, but this study they found two individuals carrying the antibody does not recognize PfEMP1, but will RIFINs molecular recognition; at the molecular level, reactive antibodies can be produced by the body's natural process of independent new event to trigger, and migration and insertion of DNA will come through this process occurs in the gene, called LAIR1 of.

Gene mutation screening tool available, will reveal the mystery of genetic disease!

Guided by public opinion, for gene mutation, people always talk about the discoloration. In fact, the vast majority of human genetic mutations are harmless, even in the hereditary disease, which is also due to pathogenic mutations showed only 1-2 genes only. Therefore, how to carry out targeted etiology research, how to distinguish between harmful and harmless gene mutation, it has been a serious challenge facing scientists.

Recently, scientists from Rockefeller University, St. Giles human infectious diseases Genetics Laboratory invented a new type of genetic screening tool Gene Damage Index, used to predict the likelihood of certain human genes causative mutations, to aid researchers screening and pathogenic mutations due to independent information from a large number of genes. Without this aid, the difficulty of screening comparable needle in a haystack, and the results are likely to deviate from the scientific truth. At present, the details of the screening tool has been published in "PNAS" (Proceedings of the National Academy of Sciences) magazine.

Gene Damage Index mainly on a gene mutation rate in the human gene pool, or the "cumulative mutations damage", but also by calculating a gene in a specific disease areas, such as Mendelian diseases, cancer, autism and primary Immunodeficiency Disease contribution to measure its pathogenic significance.

Through genomic analysis, researchers have found that 58% of rare genetic variation is only 2% of human genes detected. St. Giles Laboratory research team used this tool to detect some of the high mutation rate of the gene in healthy volunteers and in patients with genetic, whereby they infer these high mutation rate is not a genetic disease or a rare genetic disease etiology true.

Yuval Itan author of the study, said the use of Gene Damage Index screening tool, we will be able to effectively eliminate 60% of non-correlation between genetic variation and help the next generation of researchers from the vast gene sequences more quickly and effectively identify genes associated with genetic diseases mutation.

Enhance memory study found that a protein

Increase brain levels of a specific DNA recombinase can significantly improve their cognitive abilities. This finding is subject neuroscience research center headed by Prof. Hilmar Bading of Heidelberg University Cross. Mice show, Dnmt3a2 protein can improve memory. Because this protein will affect the fear of memory and the ability to remove such bad memories, researchers hope these findings can be used to develop new treatments for traumatic neurosis and other forms of anxiety. The results of this study are published in the "Molecular Psychiatry" magazine.

In an earlier study, the scientists found that low levels of Dnmt3a2 protein in the brain of aging mice. When older animals were injected with the virus produces this protein, that will increase their ability to remember. "We have now found that increasing Dnmt3a2 level in the brain of young mice can improve their cognitive abilities." Bading professor explained. In many different long-term memory tests, including typical Pavlovian conditioning experiment, the scientists were able to prove that there is more Dnmt3a2 mice behaved better.

Dnmt3a2 is an epigenetic regulator, it can be chemically modify the genetic material DNA. The result is the production of a specific protein changes in velocity. Activation of gene transcription of genetic information can be transferred to RNA, followed by the synthesis of new proteins, play an important role in memory consolidation and disappearing. Heidelberg neuroscientists and therefore in a patient using allopathic methods are similar to "eliminate" the experiment. This therapy for the treatment of traumatic neurosis, aimed interrupt or even completely eliminate disturbing relevance. We found that the brain contains a high level of Dnmt3a2 mice can eliminate the pain associated with a particular region and stimulate greater role between. "Bading explained.

How to buy Hexaplant Richter

Product name:Hexaplant Richter

Description:
Hexaplant Richter is especially designed for the care of dull hair and stressed scalp.Also suitable for skin care.The product contains extracts from the herbs fennel,hops,camomile,balm mint,mistletoe and yarrow.

For more, please click:sales@chemicalspharm.com

Non-invasive early cancer diagnosis within one hour report on the results system

AWSensors company with the European plan LIQBIOPSENS team developed a new type of liquid biopsy technique used for early diagnosis of colorectal cancer, the system can help quickly and easily conduct cancer diagnosis, and monitoring of cancer, compared to current diagnostic technology in terms of saving two-thirds of the costs.

In Spain AWSensors developed this highly sensitive molecular diagnostic system can be used to screen for cancer, which is based on liquid biopsy technique that resembles a small liquid sample of blood or saliva for analysis, enabling to complete the non-invasive diagnosis of cancer, and the technology can give the test results within an hour, when combined with the analysis of its genome is likely to obtain reliable diagnostic results, and provide help for the later development of accurate cancer chemotherapy .

This new diagnostic system will work with the Polytechnic University of Valencia developed quartz micro-sensor technology, the quartz micro-sensor technology can provide real-time analysis, a combination that can be reliably performed after DNA mutation. The new inspection system common in the next three years will be used to colorectal cancer patients blood samples for testing, and the current of colorectal cancer is the second leading cause of cancer deaths in Europe, but also, and breast, lung and prostate cancer in parallel cancer.

The current preferred method of reliable diagnosis of cancer is tumor tissue biopsy, but this method is invasive, but also very painful for the patient and expensive, and the technology is only a single aspect of the disease progression can provide information to patients; and article In this new system development, or at least three times cheaper than the cost of the current real-time monitoring methods, such as real-time quantitative PCR technology. The researchers plan to carry out this LiqBiopSens aims to develop simple, inexpensive and without early diagnosis and monitoring of invasive cancer.

By detecting mutations associated with cancer tumor tissue to release the body of DNA, the new technique can reliably existence and evolution of cancer diagnosis and avoid false positive results. Currently AWSensors has begun trying to make use of the crystal sensor so that it can work efficiently, and better detect molecular differences between different liquids biopsies and materials.