New discoveries or help develop a malaria vaccine

Scientists from the University of Oxford, etc., perhaps to find a new way to target the malaria parasite; now the impact of malaria each year with more than 40 million lives, and most patients are Plasmodium falciparum (Plasmodium falciparum) caused by infection, but life In the area of ​​malaria outbreaks often people will get a special natural state of immunity to help the body resist malaria infection in adulthood, so the discovery of the possibility of a vaccine against malaria means is from the molecular level up to reveal the body's natural immune these special groups reaction process.

When P. falciparum infection and the body hidden in the red blood cells will lead to serious cause of malaria deaths occur, after many studies have shown that the main component of the body's protective immune response against the surface antigen can be directly called variant , while Plasmodium can use this particular antigen inserted into the surface of the infected red blood cells, usually falciparum will use these molecules to control the infected cell so that it can be adhered to the inner wall of the blood vessel supply of organs, if a large number of Plasmodium infection RBC accumulation will lead to the occurrence of cerebral malaria in the brain.

Under normal circumstances falciparum can produce a variety of different variations of manufacturing surface antigen family, the process although these antigenic molecules naturally acquired immunity in malaria incidence and serious plays an important role, and it usually is because it has diversity I do not think the appropriate candidate vaccines; however Looking for specific antibodies to react with the surface antigen of Plasmodium falciparum variant seems to be able to help develop new interventions against malaria.

The researchers noted that this variant surface antigens include PfEMP1, RIFINs and STEVOR molecules, the researchers had focused on the PfEMP1 molecule research studies, but this study they found two individuals carrying the antibody does not recognize PfEMP1, but will RIFINs molecular recognition; at the molecular level, reactive antibodies can be produced by the body's natural process of independent new event to trigger, and migration and insertion of DNA will come through this process occurs in the gene, called LAIR1 of.