Stem cell therapy to humans by a cat

When the kitten Bob came to the University of California at Davis veterinary hospital, it has exhausted its nine lives; inflammation of the mouth due to the torture, Bob has been pulled all the teeth and trying to name this cat class chronic gingivostomatitis (FCGS) the fight against the disease, and finally Bob into a small clinical trial to accept a new type of stem cell therapy for treatment. Bob and other small cat as a very fortunate to enter into this clinical trial, the test was a success, Bob gained a new life.

The results of this study the researchers published in the journal Stem Cells Translational Medicine; articles first time, researchers using stem cell therapy successful and effective in the treatment of feline chronic gingivostomatitis disease; Arzi when researchers saw a lot due to treatment chronic gingivostomatitis lost all teeth cat, he opened a special treat feline disease clinical trials; feline chronic gingivostomatitis is a difficult to treat disease, researchers often see some of the cats the traditional therapy and nothing happens, so they decided to use stem cell therapy to try; first they use a cat body's own fat-derived stem cells, stem cell processing and characterizing followed then these treated stem cells cats intravenous injection to reduce the body's inflammatory cat show, and promote tissue regeneration; researchers also identified a useful biomarker, which can help determine whether the cat will react to stem cell therapy.

Arzi said, the first time we use this new technology to test mammal as an animal disease, feline chronic gingivostomatitis disease might be able to, as a new model to help develop effective treatment of human chronic inflammatory diseases of the oral cavity new therapies.

Researchers Nasim Fazel previous relevant studies organization feline chronic gingivostomatitis chronic stomatitis and human diseases and pathology characteristic of inflammatory markers in the blood. Oral lichen planus is a similar feline chronic gingivostomatitis T cell-mediated chronic inflammatory mucosal diseases, Fazel said we are pleased that the disease has made a breakthrough, because the performance of cats with the disease oral lichen planus human pathology is very similar, based on the above research, the current researchers have submitted an application to establish human clinical trials, between the use of mesenchymal stem cell therapy to treat human OLP, believed by researchers late tireless efforts of their research in this field will make new research results.

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Product name:L-biopterin

CAS:22150-76-1

Molecular Formula:C9H11N5O3

Formula Weight:237.22g/mol

Description:L-Biopterin is the oxidized form of tetrahydro-L-biopterin, a nitric oxide synthase cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture.L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.
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Product name:Pentobarbital
CAS:76-74-4
Molecular Formula:C11H18N2O3
Molecular Weight:226.27g/mol
Description:Pentobarbital is a short-acting barbiturate that was first synthesized in 1928. Pentobarbital is available as both a free acid and a sodium salt, the former of which is only slightly soluble in water and ethanol.It has also been used for physician-assisted suicide.It is used in the US state of Oregon for this purpose and is also used by the Swiss euthanasia group Dignitas.
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Product name:Pentobarbital

CAS:76-74-4

Molecular Formula:C11H18N2O3

Molecular Weight:226.27g/mol

Description:Pentobarbital is a short-acting barbiturate that was first synthesized in 1928. Pentobarbital is available as both a free acid and a sodium salt, the former of which is only slightly soluble in water and ethanol.It has also been used for physician-assisted suicide.It is used in the US state of Oregon for this purpose and is also used by the Swiss euthanasia group Dignitas.

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HL-7702

titanium oxide / chitosan composite scaffolds were prepared by a freeze-drying technique. Composite scaffolds were very porous with an average pore size of 120-300 microns, and titanium dioxide (TiO (2)) powders were uniformly dispersed on the surface of the pore walls. The compressive strength of the composite scaffolds was significantly improved compared to that of pure chitosan scaffolds. weight / chitosan composite scaffold with 0.3 TiO (2) showed resistance to the maximum compression 159.7 +/- 21 kPa. Liver immortal cell line HL-7702 was used as seed cells on the scaffold, and after periods of cultivation different investigated adhesion and cell function. HL-7702 in adhering to the walls of the scaffold pores with spheroid shape after 1 day of culture cells, but aggregates of cells in the formed TiO (2) / chitosan composite scaffolds compared to scaffolds of pure chitosan. specific functions of the liver, the secretion of albumin and urea synthesis were detected using a spectrometric method. The results showed that the secretion and urea synthesis rate of albumin HL-7702 cells slightly reduced with the time of culture, and there was no significant difference between the composite scaffolds and chitosan scaffolds pure. In conclusion, the TiO (2) / chitosan composite scaffolds had improved compared to pure chitosan scaffolds mechanical strength and supports the setting and functional expression of hepatocytes, which means that their possible application in tissue engineering of the liver.

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Product name:Thiazole
CAS: 98886-44-3
Molecular Formula: C9H18NO3PS2
Molecular Weight: 283.3479
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