Doxycycline monohydrate

Product name: Doxycycline monohydrate 
CAS no.: 17086-28-1
Molecular Formula: C22H26N2O9
Molecular Weight: 462.45
Product description: For anti-infection drugs.
For more, please click:http://www.chemicalspharm.com/New-Products/

Buffered Peptone Water

Product name:Buffered Peptone Water

Packing(g/bottle):250

Product description:
Buffered Peptone Water is intended to aid in the recovery of injured Salmonella species from foods and other samples prior to selective enrichment and isolation.

A new method of HIV research in Germany to clear

German researchers February 22 reported that they are developing a new approach is expected to help patients remove HIV from the body. Currently animal experiments have been successful.

HIV and other retroviruses, when breeding their genetic material will be integrated into the genome of the human host to replicate. Although antiretroviral therapy can effectively inhibit the reproduction of HIV, but the virus can not eradicate this type of integration. Therefore, the virus can lie dormant dormant during treatment, discontinuation of treatment once, again to start copying.

Dresden University of Technology said a press release the same day, the school in cooperation with the Heinrich Pater Hamburg Institute researchers, the use of an important tool for protein engineered "directed molecular evolution" developed a method called Brec1 recombinase. Cell specimens and test tubes in mice show that the recombinase can accurately identify the location of more than 90% of common clinical HIV strains, and can safely and accurately in the genome of infected cells completely "cut off" integrated provirus.

The so-called provirus, is present in the host chromosome, potential virus genome. Further experiments showed that this method does not destroy the function of the host cell and the normal gene. After the original virus is cleared by HIV genetic material interference and malfunction of the immune system is expected to return to normal.

The researchers say that this method is expected to bring fundamental changes to HIV treatment, so completely cure possible. In the current basis of animal experiments, the researchers have been granted preliminary clinical trials in the next body of AIDS patients.

Ulinastatin

A Kunitz-type serine protease inhibitor multivalent human urine derived, with a potential, anti-fibrinolytic and anticoagulant activities. When administered, ulinastatin (urine or trypsinogen inhibitor) inhibits the activity of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin , lipase, hyaluronidase, factors IXa, Xa, XIa and Xian, and polymorphonuclear leukocyte elastase. Moreover, ulinastatin inhibits excessive release of pro-inflammatory mediators such as tumor-necrosis factor alpha, interleukin-6 and -8, and chemokines. Overall, these agents can improve microcirculation, blood flow and function of the tissue and may protect organ damage.

Pristinamycin

A semisynthetic derivative of pristinamycin, a natural B streptogramins abundant type. Quinupristin binds to the bacterial 50S ribosome subunit, and inhibiting peptide chain of the longitudinal growth, and the extinction of the normal synthesis of bacterial protein. Quinupristin is effective especially against Gram-positive cocci.

Erucyl Alcohol

A class of compounds, where a hydroxyl (OH) hydrocarbons of the related group is connected. Alcohols are classified according to the position of the carbon atom bonded to the hydroxyl group (I.S. alcohols primary alcohols having an OH group bonded to the primary carbon atom, C1). Applications include solvents, astringents and anti-infective activity.

Peptide

type 1 (MEN1) multiple endocrine neoplasia syndrome include combinations of more than 20 endocrine and non-endocrine tumors vary. Endocrine tumors become apparent overproduction of hormones by the tumor or the tumor growth itself parathyroid tumors are endocrine disorder NEM1 senior partner. From 90% of people between 20 and 25 years with obvious hypercalcemia by age 50 hypercalcemia caused lethargy, depression, confusion, loss of appetite, constipation, nausea, vomiting, urination, dehydration, hypercalciuria, kidney stones , increased bone resorption / risk of fracture, hypertension and the shortened QT interval. Pituitary tumors include prolactinoma (most common), manifested as oligomenorrhea / amenorrhea and galactorrhea in women and sexual dysfunction in men. Well-differentiated endocrine tumors of the entero-pancreatic (GEP) gastrointestinal tract can manifest as Zollinger-Ellison syndrome (gastrinoma); Hypoglycemia (insulinoma); Hyperglycemia, anorexia, glossitis, anemia, diarrhea, and rash venous thrombosis (glucagonoma); and diarrhea, hypokalemia and achlorhydria aqueous syndrome (vasoactive intestinal peptide [VIP] secreting tumor). Carcinoid tumors secrete hormones and may be manifested by a large mass after the age of 50 years. adrenal tumors may be associated with a primary hypercortisolism or hyperaldosteronism. Non-endocrine tumors include angiofibroma face, Omas collages, lipomas, meningiomas, ependymomas and fibroids.