Peptide

type 1 (MEN1) multiple endocrine neoplasia syndrome include combinations of more than 20 endocrine and non-endocrine tumors vary. Endocrine tumors become apparent overproduction of hormones by the tumor or the tumor growth itself parathyroid tumors are endocrine disorder NEM1 senior partner. From 90% of people between 20 and 25 years with obvious hypercalcemia by age 50 hypercalcemia caused lethargy, depression, confusion, loss of appetite, constipation, nausea, vomiting, urination, dehydration, hypercalciuria, kidney stones , increased bone resorption / risk of fracture, hypertension and the shortened QT interval. Pituitary tumors include prolactinoma (most common), manifested as oligomenorrhea / amenorrhea and galactorrhea in women and sexual dysfunction in men. Well-differentiated endocrine tumors of the entero-pancreatic (GEP) gastrointestinal tract can manifest as Zollinger-Ellison syndrome (gastrinoma); Hypoglycemia (insulinoma); Hyperglycemia, anorexia, glossitis, anemia, diarrhea, and rash venous thrombosis (glucagonoma); and diarrhea, hypokalemia and achlorhydria aqueous syndrome (vasoactive intestinal peptide [VIP] secreting tumor). Carcinoid tumors secrete hormones and may be manifested by a large mass after the age of 50 years. adrenal tumors may be associated with a primary hypercortisolism or hyperaldosteronism. Non-endocrine tumors include angiofibroma face, Omas collages, lipomas, meningiomas, ependymomas and fibroids.