Effect of ozagrel

The effects of Ozagrel (CAS 82571-53-7), an inhibitor of thromboxane A2 synthetase and norphenazone (CAS 89-25-8), a free radical scavenger, on cerebral infarction were measured using occlusion induced middle cerebral artery sewing judged (MCAO) model and a model microthrombus. In the first model, the middle cerebral artery for 2 h was sealed, and the area and infarct volume were evaluated after 24 h of reperfusion. In the latter model, microthrombus were induced two injections of sodium laurate (2 days apart) in the internal carotid artery and neurological deficits were evaluated on the day afer the second injection. Ozagrel to 3 mg / kg reduced both the area and volume of cortical infarction following ischemia-reperfusion of the middle cerebral artery. Ozagrel had suppressive effects on neurological deficits in microthrombus model. Norphenazone was at 1 and 3 mg / kg no significant effect in both models. Since sewing induced MCAO model and microthrombus model models for cerebral arterial roads absorption reperfusion and lacunar infarcts respectively, these results suggest a beneficial effect of Ozagrel in clinical therapy in the race.