Aging and cultured human skin fibroblasts

We have aging at the cellular level examined by examining the skin fibroblasts cultures obtained from skin biopsy samples were obtained from the young and old members of a longitudinal study of human aging. The results of a series of studies that have been carried out, a show that has cultures of cells from ancient human donors, unlike the cultures of young donors affects cell proliferation and reduces the induction of sister chromatids. A number of other parameters were not affected by the age of the human fibroblast donor. These include the content and rate Zellprotein- and cellular macromolecular synthetic RNA. The study of the cell cultures of members of a longitudinal study in progress allows the study of correlations between in vivo and in vitro on measurements of the same person. In addition, it allows future longitudinal studies on the aging of human cells