Hepatoprotective effect of limonin

Toll-like receptors have been implicated in inflammation and lesions in various tissues and organs, including the liver. We have the limonin effect of the dichloromethane fraction of the seeds of bitter orange (Citrus aurantium var. Bigaradia) in two doses (50 and 100 mg / kg) to D-galactosamine (D-GalN) induced by liver toxicity Analyzed for comparison standard silymarin treatment on Toll-like receptors expression and liver damage, with a well-established rat model of acute inflammation of the liver. Limonoids in the seeds of sweet bitter orange have been identified. Oral administration of limonin before D-GalN injection, a significantly attenuated marker of liver damage (elevated liver enzyme activities and total bilirubin) and inflammation of the liver (TNF-α, neutrophil infiltration), Oxidative stress and TLR 2 expression in D-GalN-treated rats, limonine effects are similar to those of Lignansilymarins in most aspects. The highest dose of limonin (100 mg / kg) was numerically better performed for AST and bilirubin, and both doses gave similar results for ALT and GGT. While the lowest dose of limonin (50 mg / kg) better compared against oxidative stress and liver structural damage at the higher dose. Limonin practice on the liver toxicity associated with inflammation and tissue injury by attenuation of inflammation and reduction of protection against oxidative stress

Acteoside price

Product Name: Acteoside

CAS: 61276-17-3

Molecular Weight: 624.59 g / mol

Molecular formula: C29H36O15

Description: Acteoside is a phenylpropanoid, which has been reported as a chemical component of different plant species and has been isolated as a pure compound on RP-HPLC from violet flowers of Syringa vulgaris. At the pharmacological examination of this compound showed a dose-dependent decrease in sytolischen, diastolic and mean arterial pressure in the pentothal of anesthetized rats.

Bicuculline for sale

Product: (+) - bicuculline

CAS: 485 & ndash; 49 & ndash; 4

Molecular Weight: 367.35 g / mol

Molecular formula: C20H17NO6

Description: bicuculline is a competitive antagonist sensitive to light from GABA receptors. The effect of bicuculline is located mainly on the GABAA ionotropic receptors, in which they are ligand-dependent ion channels that are mainly related to the passage of chloride ions through the cell membrane and thus an inhibiting effect on the target neuron. These receptors are the main targets for benzodiazepines and related anxiolytic drugs.

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Product: Celastrol

CAS Number: 34157-83-0

Molecular Weight: 450.61 g / mol

Molecular formula: C29H38O4

Description: Celastrol, a vegetable triterpene, has these effects. At nanomolar concentrations was found that Celastrol preventing the production of human monocytes and macrophages of pro-inflammatory cytokines TNF-alpha and IL-1 beta. Celastrol also reduced the expression induced by MHC class II molecules by microglia. In stem cells of macrophages and endothelial cells induced by Celastrol has reduced but not constitutive NO production. Celastrol's powerful antioxidant and anti-inflammatories and their effects on cognitive functions suggest that the drug may be useful in neurodegenerative diseases accompanied by inflammation to treat, such as AD.

What is Salidroside

Product: Salidroside

CAS: 10338 & ndash; 51-9

Molecular weight: 300.3 g / mol

Molecular formula: C14H20O7

Description: Salidroside is a potent adaptogenic drug that is extracted from Rhodiola species. It is a glucoside that is found in the plant Rhodiola rosea. It is believed to be one of the compounds that are responsible for the antidepressant and anxiolytic effects of this plant, as well as Rosavin.

How to buy Docetaxel Anhydrous

Product Name: Docetaxel Anhydrous
CAS: 114977-28-5

Molecular Weight: 807.9 g / mol

Molecular formula: C43H53NO14

Detailed Description: Anhydrous docetaxel is an off-white microcrystalline powder white. Store at 2-8 ° C, in tightly closed containers and protected from light and moisture schützen.Es belongs to Wirkstoffen.Löslich Pharmaceutical in methanol and ethanol, insoluble in water.

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Product Name: Irinotecan HCl

CAS: 136572-09-3

Molecular Weight: 677.19 g / mol

Molecular formula: C33H38N4O6 · HCl 3 · (H 2 O)

Description: It is yellow or light yellow crystalline powder. Slightly soluble in water, ethanol or chloroform, almost inseparable in Aceton.Irinotecan hydrochloride (CPT-11) is an intravenous antineoplastic agent. Irinotecan Hydrochloride is a potent anticancer drug with activity in a wide range of tumor models. It also showed small cell responses and non-small cell lung cancer, pancreatic cancer, refractory lymphoma, malignant glioma and gynecological cancers.