Hepatoprotective effect of limonin

Toll-like receptors have been implicated in inflammation and lesions in various tissues and organs, including the liver. We have the limonin effect of the dichloromethane fraction of the seeds of bitter orange (Citrus aurantium var. Bigaradia) in two doses (50 and 100 mg / kg) to D-galactosamine (D-GalN) induced by liver toxicity Analyzed for comparison standard silymarin treatment on Toll-like receptors expression and liver damage, with a well-established rat model of acute inflammation of the liver. Limonoids in the seeds of sweet bitter orange have been identified. Oral administration of limonin before D-GalN injection, a significantly attenuated marker of liver damage (elevated liver enzyme activities and total bilirubin) and inflammation of the liver (TNF-α, neutrophil infiltration), Oxidative stress and TLR 2 expression in D-GalN-treated rats, limonine effects are similar to those of Lignansilymarins in most aspects. The highest dose of limonin (100 mg / kg) was numerically better performed for AST and bilirubin, and both doses gave similar results for ALT and GGT. While the lowest dose of limonin (50 mg / kg) better compared against oxidative stress and liver structural damage at the higher dose. Limonin practice on the liver toxicity associated with inflammation and tissue injury by attenuation of inflammation and reduction of protection against oxidative stress