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Teprenone, an anti-ulcer drug, was reported by stimulating gastric mucus synthesis and secretion of the healing of chronic gastric ulcer induced by acetic acid in rats to promote. Recently, there has been involved the infiltration of neutrophils and lipid peroxidation in the ulcerated stomach tissues have an inhibitory effect on the healing of chronic gastric ulcer induced by acetic acid in rats. Therefore, we tried to clarify whether teprenone a healing exercise tips on chronic gastric ulcers induced by acetic acid by its inhibitory effect on neutrophil infiltration and lipid peroxidation in gastric tissue effect ulcerated . In rats with chronic diseases by acetic acid from gastric ulcers in the stomach, the healing of gastric ulcer started later than 3 days after the application of acetic acid. gastric mucosal myeloperoxidase activity (MPO), an index of tissue neutrophil infiltration and lipid peroxide levels were higher in the ulcerated area and the unspoiled, 8, 15 and 22 days after application of acetic acid. non gastric protein SH content was lower in the ulcerated area and intact area on 8, 15 and 22 days after application of acetic acid and gastric mucosal adherent mucus content was lower in the ulcerated area and the intact area on day 8 and 15. daily oral administration of teprenone (100 mg kg (-1) x 2) for 7 or 14 days, on the 8th day after the application of acetic acid in the stomach from the reduction of the ulcer area improves damping with these biochemical changes found in the ulcerated region. The administration of teprenone leads to a decrease in MPO activity and an increase in adherent mucus content in the gastric mucosa of the intact region. These results suggest that the promotion of healing effect may be due to teprenone chronic gastric ulcers induced by acetic acid in rats, not only on the stimulation of the stomach mucus secretion, but also to inhibition of the infiltration of neutrophils and improvement of lipid peroxidation in the tissues of the stomach ulcerated.