What is Isoquinoline

Parkinson's disease is believed to be caused by some unknown endogenous or exogenous factors that interact with genetic material. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin exogenous parkinsonism in humans, monkeys and different animals due to the monoamine oxidase type B Preparation of (MAO B) the reaction catalyzed in the pyridinium 1-methyl-4-phenyl-ion (MPP +), which selectively kills dopaminergic nigrostriatal neurons. Various isoquinoline derivatives have been in the brains of patients with Parkinson's disease. Isoquinoline neurochemical characteristics similar to MPTP, and they are called endogenous neurotoxins be the cause of Parkinson's disease. Among these tetrahydroisoquinoline (TIQ), 1-benzyl-TIQ and (R) -1,2-dimethyl-5,6-dihydroxy-TIQ [(R) -N-methyl-salsolinol)] have the most powerful neurotoxicity . ITQ that MPTP can be activated via the N-methylation of N-methyltransferase and oxidation MAO. QIT and MPP + I of the electron transport system complex to inhibit the mitochondria, thereby reducing the formation of ATP and the production of oxygen radicals. Although ITQ properties are similar to those of the MPTP neurotoxicity QIT is lower than that of MPTP. Since Parkinson's disease is a neurodegenerative disease slowly progressive, long-term neurotoxic effects of IQS remains to be studied in primates.