Mebeverine price

Antispasmodic drug Intestinal Mebeverine vivo is known to undergo rapid enzymatic hydrolysis in Mebeverine veratric and alcohol. HPLC method with reversed phase coulometric detection test was developed in the form of secondary metabolites unidentified Mebeverine acid. After a single dose of 405 mg Mebeverine hydrochloride in four healthy volunteers, peak plasma concentrations were found to Mebeverine acid 1,000 times higher than Mebeverine alcohol, about 3 micrograms / ml compared to 3 ng / ml. The incidence of Mebeverine acid in plasma (mean T (max) = 1.25 h) and their disappearance (t apparent median (1/2) = 1.1 h) were fast. Urinary excretion of Mebeverine acid within 4 hours after the first ingestion amounted to 67% of the Mebeverine dose (median: 23-107%). the Mebeverine acid seems a valuable marker for oral exposure are on mebeverine.