What is bronopol

Bronopol (2-bromo-2-nitropropane-1,3-diol) as an antimicrobial agent in cosmetics, external pharmaceuticals, shampoos and bath products used. In liquid phase inverted pullup method of separation by chromatography with a UV spectrophotometric detection was developed for the determination of bronopol and its degradation products. Degradation of bronopol was observed in an aqueous medium, which allows to irreproducible data. To solve this problem, the HPLC methanol (water content <0.05%) was used for sample preparation. In addition, the parameters of bronopol HPLC analysis were optimized. It has been found that bronopol standards and product samples for at least 1 month were stable at room temperature in methanol, which allows a quantitative and reproducible determination of bronopol.