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This study compared the efficacy and safety of the 8 weeks of treatment open the dihydropyridine calcium antagonist amlodipine and nitrendipine mild to moderate hypertension. The interim analysis of the data of 74 patients (43 men, 31 women) showed that the normalized diastolic blood pressure amlodipine (less than or equal to 90 mmHg) at 95% of patients compared with 83% of patients treated with nitrendipine. Nitrendipine produced a statistically significant increase in heart rate at 2 and 4 weeks of treatment, but there was no significant change in heart rate in patients treated with amlodipine. Amlodipine in patients less side effects (26%) than the nitrendipine group treated (47%), with two patients in the nitrendipine group treatment discontinuation due to adverse events related to treatment. Adverse events in the amlodipine-treated group were mild to moderate. The incidence of flushing was higher in patients treated with nitrendipine (25%) than in patients treated amlodipine (10%). This difference in the incidence of side effects vasodilators is probably explained by the gradual onset of action with amlodipine.