9-bromo-1-nonanol

9-bromo-5-morpholino-tetrazole [1,5-c] quinoline cytotoxicity (BMT) is applied to the cell line L1210 murine leukemia and carcinoma cells of the Caco-2 colon. We have the two highest concentrations of BMTQ (149.2 and 74.6 microM) induces an acute cytotoxic effect, but other concentrations tested (<74.6 microM) exhibits a / dependent cytotoxic effect depending on the time and / concentration. The sensitivity of mouse leukemia L1210 cells and carcinoma cells of the Caco-2 colon was expressed in the same order. Cytotoxicity BMTQ not bound by changes in the cell cycle profile. After the effects of cytotoxicity associated BMTQ we observed induction of ssDNA breaks after BMTQ treatment. All BMTQ concentrations increases the level of ssDNA breeze 1.3-2.9 times (after 2 hours of treatment) and 1.6-2.8 times (after 4 hours of treatment) in Caco-2 cells compared to control. No apoptotic DNA fragmentation was induced by BMTQ in Caco-2 cells is recorded.

Would like to ask specific details, please click here Email:sales@chemicals-chemicals.net