Replacement of hydrogen atoms by fluorine substituents into organic substrates is of great interest in synthetic chemistry due to the high electronegativity of fluorine and relatively small steric hindrance fluorine atoms. Many nucleophilic fluorine sources are available for the derivatization of organic molecules under acidic conditions, basic and neutral. However, electrophilic fluorination historically required molecular fluorine, whose notorious toxicity and explosive tendencies limit its application in research. The need for an electrophilic fluorination reagent, secure, stable, highly responsive and accessible to industrial production as an alternative, it is very hazardous molecular fluorine was the inspiration for the discovery of Select. This reagent is not only an electrophilic fluorination of available reagent, but it is also safe, non-toxic and easy to handle. In this article, we describe the many applications Select and discuss possible ways for its reaction.
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