Graphene oxide

Cloning and Expression
Using a bovine cDNA NOS II related to the screen 2. Human genomic libraries, Bloch et al. (1995) isolated clones, the 3 independent genes. A clone encoding the gene already identified, formerly NOS2 and referred the NOS2A (163,730). The other two genes specified amino acids homologous, but not identical, to the value specified in the NOS2A gene; these were referred NOS2B (600,719) and NOS2C.
Gene Function
Diefenbach et al. (1999) studied the relationship between IL 12 (see161560) and nitric oxide synthase 2 (NOS2) in innate immunity against Leishmania parasite in mice. In the absence of IL12 activity NOS2 propagation of Leishmania parasites could prevent, do not stimulate natural killer cell cytotoxicity or interferon-gamma (147 570) Emptying and failed to activate TYK2 (176 941) and the tyrosine phosphorylation of STAT4 ( 600 558), the central IL12 transducer signal NK cells. Enabling TYK2 in NK cells by IFN-alpha / beta (type I interferon; see107470) NOS2 also necessary. Thus NOS2 N derivative is a prerequisite for cytokine signaling and function in innate immunity

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