Published in the "Stem Cell Reports" magazine, the results overturned an assumption - from different tissue cell types, "epigenetic memory" significantly affect induced pluripotent stem (iPS) cells differentiation.
Under laboratory conditions, iPS cells derived from human cells. Such an unlimited number of iPS cells can be cultured, if necessary, they can differentiate into the desired cell type, such as heart, liver, or nerve cells.
Medical research can be used in many different ways to use iPS cells, for example, in order to study the mechanism of disease or drug screening - which can turn them into perfect biological material. However, so far it is not clear whether iPS cells derived from different cell types, or their differentiation from the original tissue.
To solve this problem, researchers at the University of Helsinki, the use of the full range of analytical methods compared iPS cells from the skin and the characteristics of iPS cells derived from blood: In addition to gene expression, they studied DNA methylation and spontaneous and direct stem cells differentiation capacity.
According to a previous study showed that the researchers focused on determining whether human iPS cells have "epigenetic memory", that is, compared with stem cells derived from skin cells, blood cells derived from stem cells would be easier to differentiate into blood cells.
The findings are clear: several different indicators, when the re-differentiation of stem cells undifferentiated primitive cells.
Professor Timo Otonkoski Helsinki University, said: "Obviously, from the different cell types of pluripotent stem cells are completely equal results for biological information base is very important because you can use this method to gather information from different sources to obtain cells. features, live cell samples previously stored still useful for the production of iPS cells. "
Surprisingly different iPS cells from different people. Donor genotype significantly affect the behavior of stem cell differentiation.
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