Astilbin introduced in the body can improve kidney

Astilbin is a flavonoid compound from the rhizome of Smilax China L. isolates the effects and possible mechanisms of hyperuricemia and Astilbin nephropathy rats were elucidated in this study. Different doses of astilbin (1.25, 2.5 and 5.0 mg / kg) were administered to rats 10% hyperuricaemic induced by fructose. The results showed that the level of inhibiting uric acid (Uur) and fractional excretion of urate plane (Acta) Astilbin significantly serum urate (Su) reduced, but not by an increase in the xanthine oxidase (XOD ) activity. In addition, the parameters of renal function such as serum creatinine (SCR) and blood urea nitrogen (BUN) were recovered in Astilbin rats hyperuricemia. Other studies have shown that renal damage astilbin prevented against the expression of β1 transforming growth factor (TGF-ß1) and connective tissue growth factor (CTGF), and significant renal protection function by the formation of urate (MSU) inhibiting the production of prostaglandin E₂ (PGE₂) and interleukin-1 (IL-1). These results provide strong evidence for the Astilbin as safe and promising lead in the development of the disease preventing hyperuricemia drug and nephropathy.