What is Cyanoacetamide

The derivatives of cyanoacetic acid are the starting materials for a variety of reactions to several components (MCR) frames. Here we describe the general procedures useful for the synthesis of arrays of 2-aminothiophene-3-carboxamides of cyanoacetamide, aldehydes or ketones and sulfur via a Gewald 3CR variation. In many cases, the reactions involve a very convenient workup simply by precipitation in water and filtration. > 40 new products are described. We see our protocol and derivatives resulting become very valuable too strong MCR extended framework area of cyanoacetamide derivatives.