Leptin for sale

Diabetes is one of the biggest problem in the world. Despite some progress in the development of new anti-diabetic agents, the ability to maintain tight glycemic control to prevent kidney, retina and neuropathic complications of diabetes without adverse complications remains a challenge. However, recent results suggest that in addition to playing a key role in regulating energy homeostasis of the hormone leptin adiposity plays an important role in the control of glucose metabolism through its actions in the brain. This review focuses on the role of leptin action in the central nervous system and the mechanisms by leptin mediates its effects to regulate glucose metabolism. These results suggest that defects or defects in the leptin signaling may contribute to the etiology of diabetes and raise the possibility that either leptin or downstream targets of leptin may have therapeutic potential for the treatment of diabetes.