High levels of carbon monoxide in exhaled volume and risk of stroke and transient cerebral ischemic attack related

A new study shows that high levels of exhaled carbon monoxide levels and stroke and transient ischemic attack (transient ischemic attack, TIA) risks associated, and with a higher burden of subclinical cerebrovascular diseases have some relevance. The results published in the 2015 American Heart Association (AHA) annual meeting.
Dr. Matthew G. Nayor et al Brigham and Women's Hospital analyzed 3313 participants from the Framingham Offspring Study, and no evidence of stroke or TIA at baseline. All participants underwent a measurement of the amount of carbon monoxide exhaled, based on the concentration of carbon monoxide in exhaled stratified by tertiles (≤4 millionth [parts per million, ppm];> 4ppm to <5ppm; ≥5ppm). In addition, 1,982 participants were cranial MRI scans.
Researchers conducted an analysis of the entire cohort, and for 2819 non-smokers were analyzed, with an average follow-up time was 12.9 years.
Nayor et al reported that after adjusting for age and gender, the amount of carbon monoxide in exhaled lower third of the participants in the previous whole brain volume, white matter hyperintensity volume higher and higher proportion of asymptomatic cerebral infarction (P <0.05).
After the exclusion of smokers, the relationship with whole brain volume and white matter hyperintensity volume still exists and adjusted multivariate relationships with white matter hyperintensity volume still exist (P = 0.04).
After adjusting for age and gender, and compared to 1/3 in the 1/3 (HR = 1.67; 95% CI, 1.2-2.32) and former 1/3 (HR = 1.97; 95% CI, 1.41-2.76 ) the risk of stroke and TIA increases. The exclusion of smokers, this result still holds (in 1/3: HR = 1.68; 95% CI, 1.21-2.35; before 1/3: HR = 1.63; 95% CI, 1.09-2.44).
When Nayor, who adjust vascular risk factors, the results weakened to some extent, but after further adjustment BNP and C-reactive protein, this result remains.
"In order to explore the relationship between the biological mechanisms of carbon monoxide and stroke, still need further study." Nayor, who said in the summary.