Recently, a new study published in international academic journals
NEJM first to suggest a type 2 diabetes drug can significantly reduce
hospitalizations for heart failure and lead to death.
The findings come from a known EMPA-REG OURCOME of large clinical
trials, from Yale University, Dr. Silvio E. Inzucchi held in Orlando in
2015 the American Heart Association scientific meetings about the
progress of this research.
Many
patients with type 2 diabetes are also at the same time the presence of
heart failure, the heart they can not effectively pump blood into the
circulation system. The
current treatment of treatment of heart failure is very limited, but
some studies have found no previous treatment of type 2 diabetes in
heart failure have a therapeutic effect. But an increase in the blood glucose is discharged through urine by
new therapeutic drugs to achieve glycemic control (SGLT2 inhibitors) has
not been studied.
In
this EMPA-REG experiments, researchers will have type 2 diabetes in
patients with heart disease risk while randomized, to some patients
taking a new antidiabetic drugs --empagliflozin (10mg or 25mg dose) each
day, as well as Some patients taking placebo. Drug and placebo are administered in addition to standard treatment.
To
the end of the experiment, the researchers found that compared with
patients taking placebo, patients taking the drug blood sugar and blood
pressure declined, while weight also declined. They also found that patients taking the drug died of heart disease,
the proportion declined significantly; the proportion of
hospitalizations due to heart failure also appears significantly
decreased; the proportion of deaths from any cause was also
significantly decreased.
In
addition, Inzucchi and colleagues there and the absence of heart
failure, heart failure patients with type 2 diabetes start of the test
carried out further analysis showed that the ratio of these two groups
of patients had decrease in hospitalizations are similar, So they come to a conclusion, empagliflozin already suffering not only
to prevent further deterioration in patients with heart failure, but
also not suffering from heart failure can help prevent heart failure in
patients with diabetes.
August
2014 Boehringer Ingelheim - Lilly Diabetes Federation announced,
diabetes DRUG Jardiance (empagliflozin) approved by the FDA, combined
with diet and exercise for adult patients with type 2 diabetes therapy
to improve blood sugar control.
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