pejvak molecules in the body's hearing system plays an important role

Recently, scientists from the Pasteur Institute, etc. The study found a molecular feature called pejvakin of, pejvakin molecules in the body's hearing system plays an important role, the molecule is missing is the main cause of noise-induced hearing loss, and noise-induced hearing loss is a common cause of deafness, the study published in the International Journal of Cell.
Back in 2006, the researcher identified through a joint research initiated early sensorineural hearing loss novel gene and protein encoded by this gene, called pejvakin, by measuring the hearing test results show that the gene mutation individuals On hearing impairment showed abnormally high levels of diversity; in this latest study, the researchers aim is to cause of disease heterogeneity classification.
Article, researchers pejvakin gene inactivation young mice, the researchers found that among different mouse mutants will lead to hearing damage mice hearing loss from mild to severe, born during the first three mice week given a higher noise, especially during feeding; As the number of mice in cages, which are more and more noisy acoustic environment, researchers observed, as the number of mice in the cage increases, Listening boundaries mice also increases, the minimum level of sound that is heard more and more obvious; the use of the direct control of acoustic stimuli, the scientists discovered that the auditory system pejvakin gene deficient mice is affected by the acoustic environment.
Then the scientists investigated the cause of this phenomenon physiology, researchers in mice missing pejvakin the body observed in mice exposed to a seemingly harmless once sound environment, they will damage the auditory sensory cells; auditory senses cells need two weeks to restore functionality silence again, with longer or repeated exposure to this environment, mouse auditory sensory cells of the body will die; at the same time the scientists also found that the cells in noise-sensitive element is a peroxisome, that can participate in detoxification organelles, simply, a genetic disorder caused by noise-induced hearing loss can be a very low noise level targeting.
the body of the patient pejvakin auditory sensory cell damage often susceptible to noise, and when the individual hearing defect standardized listening tests, the reaction of their auditory sensory cells or neurons Though initially appeared normal, but as tests on It becomes worsening, even loss of function occurs. Noise induced hearing loss occurs more frequently in the population, the urban population centralization means cities will become increasingly noisy, especially in developed countries, according to WHO speculated that by 2030 there will be 1 billion people will risk in noise-induced hearing loss among.
Scientists hope to use existing tools to help restore pejvakin gene function, especially the use of gene therapy to restore its function, and gene therapy has been shown to successfully restore hearing pejvakin deficient mice, even in excessive mouse exposure to noise can still be successfully restored hearing in mice.