Scientists clarify the key mechanisms of memory formation

Researchers from the Scripps Research Institute study found, a brain protein interaction of children may have a memory to produce a significant effect, related research or for the treatment of neurodegenerative diseases develop new drugs to provide ideas; the study published in the international journal Cell, the article researchers conducted a major study of the two receptors, one of which is the neurotransmitter dopamine, which is mainly involved in learning, memory, Reward behavior, motion control, and other functions, the other one ghrelin receptors, which can be interconnected together with appetite and energy usage.
The researchers Professor Roy Smith pointed out that in an animal model study, we found that when the two receptor interactions, ghrelin receptor will change the structure of the dopamine receptor, while changing its signaling pathway, which is very important because many clinical drugs are developed based on this, such as schizophrenia, the patient compliance will be less because the reverse side effects of the performance, the study or to make use of neuronal preparations by targeting ghrelin Su indirect modification of dopamine, thereby reducing potential side effects.
Current studies or potential significance, or researchers to develop new strategies to selectively adjust the memory associated with neuronal dopamine signal, and the use of small molecules with gastric ghrelin receptor can enhance or inhibit dopamine signal ; researchers said biologically active ghrelin receptor complex will produce synaptic plasticity and ability to promote the growth and expansion of brain synapses.
Prior to the study the researchers clarify the neurons critical role in the regulation of food intake, insulin release and immune system decline in the ghrelin receptor, and this paper is to expand the importance of ghrelin receptor understanding in animal models, ghrelin receptor can inhibit and Parkinson diseases, stroke and other diseases related to neuronal loss, and perhaps this study for the treatment of late-stage development of memory deletion, targeted therapy of age-related neurological diseases provide ideas.


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