1,3-Cyclohexanediol

The use of iodine as catalyst and either acetic acid or trifluoroacetic acid studied as derivatization reagent for the determination of the enantiomeric composition of aliphatic alcohols acyclic and cyclic chiral. Optimal conditions were selected on the molar ratio of acid to alcohol, the reaction time and the reaction temperature. Thereafter, the chiral stability was examined by chiral carbons. Although no isomerization was observed when the acetic acid was used, partially isomerization was detected with trifluoroacetic acid. A number of chiral alcohols with a type of widely varying structure were then derivatized with acetic acid using the optimum conditions. The resolution of the enantiomers and esters of the free chiral alcohols mounted measured using a capillary gas chromatograph phase with a Chirasil DEX CP-CB column. The best decisions are obtained with the acetate of 2-pentyl (α = 3.00) and acetate of 2-hexyl (α = 1.95). This method is used to analyze experimental work process very simple and effective for the preparation of chiral alcohols by phase chiral GC.