Microbial control group of us? Or do we control it?

After all, we can control our gut. A recently published paper describes the discovery of this attractive, it reveals that they can control the mouse intestinal microbial composition and behavior, and human beings have such potential. This finding subvert the mainstream concept. Mainstream idea that exist in our gut complex ecosystem in fact is our master, and we were just marionettes it, it changes our brain biochemical function even on the immune system also have an impact, let us fight infections and help us decompose excess burgers and fries.

Harvard Medical School and Brigham and Women's Hospital in Boston (Brigham and Women's Hospital) researchers found in a series of carefully designed experiments in mice feces from their gastrointestinal tract filled with small non-coding RNA, namely microRNAs. These biomolecules may shape and adjust the microorganisms in mice. Professor of genetic epidemiology at King's College, University of London Tim Spector is The Diet Myth: Why the Secret to Health and Weight Loss Is Already in Your Gut of the author, who was not involved in the study, which he said: "Over the years we have know that microbes can affect human health, and to some extent we have long suspected this is a two-way process, but the idea never really confirmed. the study good explanation of two-way between us and microbes interaction, it shows in this interactive relationship, how we affect the microorganisms, this fascinating. "

More importantly, the researchers found that mice with human feces stool has the same 17 kinds of microRNA, which may indicate human and mice have a similar mechanism. This may also open up new therapeutic approach comprising a transplant, including microRNA. The study, published in the journal Cell Host & Microbe, its first author, neuroscientist at Harvard Medical School and Brigham and Women's Hospital in Boston Howard Weiner said: "Obviously, it raises an urgent question: 'microRNA It came from, why they are here? ' "

Howard Weiner and compared those specially bred, certain types of cells in the digestive tract of mice missing microRNA normal mice, to answer the question "microRNA come from," the. Cultivation of other special cell microRNA in mice did not change, but they still lack the feces of microRNAs, which indicates that the microRNA usually located between the intestinal fecal microRNA and there is a link. They concluded that these particular RNA from two gastrointestinal epithelial cells from the evidence.

The researchers also tried to check only 18-23 nucleotides tiny RNA is how it works to answer the "why" of this problem. Weiner and his colleagues found that the epithelial cells of the microRNA is not just a passerby. Surprisingly, their role seems to be very subtle, and can adjust the microorganism itself. The study found little mice in vivo intestinal microRNA more susceptible to colitis. But through the catheter to the intestinal disease, these mice transplanted microRNA from normal mice, these diseased mice began to produce more normal bowel substances. Spector was not involved in the study said that this series of experiments designed very "clever."

In determining these key findings, the researchers were also able to see different microRNA by a more natural way to change mice specific bacteria. The researchers added to the drinking water of mice that facilitates the growth of E. coli synthetic microRNA. After drinking this water for two days, the mice faeces of E. coli was increased by about two times, which can be confirmed by introducing a specific microRNA intestinal. Weiner said: "I think our study increases the likelihood of a particular microorganism to adjust, I think it opens up many possibilities."