What is Syndecan-1

The protein encoded by this gene is a transmembrane (type I), heparan sulfate proteoglycan and is a member of the family of proteoglycans syndecan. The organization of syndecan mediate cell binding, cell signaling and cytoskeletal and syndecan receptors are required for the internalization of the HIV-1 tat protein. Syndecan-1 protein acts as an integral membrane protein and is involved in cell proliferation, cell migration and cell-matrix interactions through its receiver to the proteins of the extracellular matrix. Altered expression of syndecan-1 was detected in several tumor types. Although several transcription variants may exist for this gene, the full length of only two types have so far been described. These two variants are the most important of this gene and the same encoding the protein